Topical skin penetration of diclofenac after single- and multiple-dose application

International Journal of Clinical Pharmacology and Therapeutics

Volumn 42, Issue 7, 2004, Pages 353-359

  Dehghanyar, P ^a   Mayer, B X ^a   Namiranian, K ^a   Mascher, H ^b   Muller M ^a   Brunner, Martin ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Pharmanalyt GmbH   (Austria)

Author keywords

Diclofenac; Human skin; Microdialysis; Transdermal penetration

Indexed keywords

DICLOFENAC DIETHYLAMINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG PENETRATION; DRUG TOLERABILITY; GEL; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; MICRODIALYSIS; MULTIPLE DRUG DOSE; NORMAL HUMAN; SINGLE DRUG DOSE; SKIN PENETRATION; SUBCUTANEOUS TISSUE; VOLUNTEER;

EID: 3242793346     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP42353     Document Type: Article

References (41)

1. Austria Codex Fachinformation 2000 Österreichische Apotheker-Verlagsgesellschaft M.B.H., Vienna, Austria
2. Benfeldt E, Serup J, Menne T 1999 Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and noninvasive quantification of barrier function. Br J Dermatol 140: 739-748
3. Borg N, Gotharson E, Benfeldt E, Groth L, Stahle L 1999 Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers: comparison of the suction blister technique and cutaneous microdialysis. Acta Derm Venereol 79: 274-277
4. Burian M, Tegeder I, Seegel M, Geisslinger G 2003 Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. Clin Pharmacol Ther 74: 113-120
5. Cross SE, Anderson C, Thompson MJ, Roberts MS 1997 Is there tissue penetration after application of topical salicylate formulations? Lancet 350: 636
6. Dawson M, McGee CM, Vine JH, Nash P, Watson TR, Brooks PM 1988 The disposition of biphenylacetic acid following topical application. Eur J Clin Pharmacol 33: 639-642
7. Gallacchi G, Marcolongo R 1993 Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion. Drugs Exp Clin Res 19: 95-97
8. Grahame R 1995 Transdermal nonsteroidal anti-inflammatory agents. Br J Clin Pract 49: 33-35
9. Griffin MR 1998 Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury. Am J Med 104: 23-29
10. Groth L, Jorgensen A 1997 In vitro microdialysis of hydrophilic and lipophilic compounds. Anal Chim Acta 355: 75-83
11. Guy RH, Hadgraft J, Bucks DA 1987 Transdermal drug delivery and cutaneous metabolism. Xenobiotica 17: 325-343
12. Hadgraft J 1989 Formulation of anti-inflammatory agents. In: Hensby C, Lowe NJ (eds) Nonsteroidal anti-inflammatory agents. Karger, Basel, pp 21-44
13. Higo N, Naik A, Bommannan DB, Potts RO, Guy RH 1993 Validation of reflectance infrared spectroscopy as a quantitative method to measure percutaneous absorption in vivo. Pharm Res 10: 1500-1506
14. Hippius M, Uhlemann C, Smolenski U, Schreiber U, Reissig S, Hoffmann A 1998 In vitro investigations of drug release and penetration - enhancing effect of ultrasound on transmembrane transport of flufenamic acid. Int J Clin Pharmacol Ther 36: 107-111
15. Kreilgaard M, Kemme MJ, Burggraaf J, Schoemaker RC, Cohen AF 2001 Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics. Pharm Res 18: 593-599
16. Kreilgaard M 2002 Assessment of cutaneous drug delivery using microdialysis. Adv Drug Deliv Rev 54: 99-121
17. Lundin A, Berne B, Michaelsson G 1992 Topical retinoic acid treatment of photoaged skin: its effects on hyaluronan distribution in epidermis and on hyaluronan and retinoic acid in suction blister fluid. Acta Derm Venereol 72: 423-427
18. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR 1993 Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 90: 11693-11697
19. Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ 1998 Quantitative systematic review of topically applied nonsteroidal anti-inflammatory drugs. BMJ 316: 333-338
20. Müller M, Schmid R, Georgopoulos A, Buxbaum A, Wasicek C, Eichler HG 1995a Application of microdialysis to clinical pharmacokinetics in humans. Clin Pharmacol Ther 57: 371-380
21. Müller M, Schmid R, Wagner O, v Osten B, Shayganfar H, Eichler HG 1995b In vivo characterization of transdermal drug transport by microdialysis. J Control Release 352: 438-441
22. Müller M, Mascher H, Kikuta C, Schäfer S, Brunner M, Dorner G, Eichler HG 1997 Diclofenac concentrations in defined tissue layers after topical administration. Clin Pharmacol Ther 62: 293-299
23. Müller M, Rastelli C, Ferri P, Jansen B, Breiteneder H, Eichler HG 1998 Transdermal penetration of diclofenac after multiple epicutaneous administration. J Rheumatol 25: 1833-1836
24. Müller M 2002 Science, medicine and the future: microdialysis. BMJ 324: 588-591
25. Pershing LK, Corlett J, Jorgensen C 1994 In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum. Antimicrob Agents Chemother 38: 90-95
26. Radermacher J, Jentsch D, Scholl MA, Lustinetz T, Frolich JC 1991 Diclofenac concentrations in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease. Br J Clin Pharmacol 31: 537-541
27. Riess W, Schmid K, Botta L, Kobayashi K, Moppert J, Schneider W, Sioufi A, Strusberg A, Tomasi M 1986 The percutaneous absorption of diclofenac. Arzneimittelforschung 36: 1092-1096
28. Rougier A, Dupuis D, Lotte C, Roguet R, Wester RC, Maibach HI 1986 Regional variation in percutaneous absorption in man: measurement by the stripping method. Arch Dermatol Res 278: 465-469
29. Seth BL 1992 Comparative pharmacokinetics and bioavailability study of percutaneous absorption of diclofenac from two topical formulations containing drug as a solution gel or as an emulsion gel. Arzneimittelforschung 42: 120-122
30. Shah VP, Flynn GL, Yacobi A, Maibach HI, Bon C, Fleischer NM, Franz TJ, Kaplan SA, Kawamoto J, Lesko LJ, Marty JP, Pershing LK, Schaefer H, Sequeira JA, Shrivastava SP, Wilkin J, Williams RL 1998 Bioequivalence of topical dermatological dosage forms - methods of evaluation of bioequivalence. Pharm Res 15: 167-171
31. Singh P, Roberts MS 1994 Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application. J Pharmacol Exp Ther 268: 144-151
32. Sioufi A, Pommier F, Boschet F, Godbillon J, Lavoignat D, Salliere D 1994 Percutaneous absorption of diclofenac in healthy volunteers after single and repeated topical application of diclofenac Emulgel. Biopharm Drug Dispos 15: 441-449
33. Skoutakis VA, Carter CA, Mickle TR, Smith VH, Arkin CR, Alissandratos J, Petty DE 1988 Review of diclofenac and evaluation of its place in therapy as a non-steroidal antiinflammatory agent. Drug Intell Clin Pharm 22: 850-859
34. Stagni G, O 'Donnell D, Liu YJ, Kellogg DL, Morgan T, Shepherd AM 2000 Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis. J Control Release 63: 331-333
35. Tegeder I, Muth-Selbach U, Lotsch J, Rusing G, Oelkers R, Brune K, Meller S, Kelm GR, Sörgel F, Geisslinger G 1999 Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration. Clin Pharmacol Ther 65: 357-368
36. Tegeder I, Lotsch J, Kinzig-Schippers M, Sörgel F, Kelm GR, Meller ST, Geisslinger G 2001 Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen. Pharm Res 18: 980-986
37. Todd PA, Sorkin EM 1988 Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 35: 244-285
38. Treffel P, Muret P, Muret-D'Aniello P, Coumes-Marquet S, Agache P 1992 Effect of occlusion on in vitro percutaneous absorption of two compounds with different physicochemical properties. Skin Pharmacol 5: 108-113
39. Vaile JH, Davis P 1998 Topical NSAIDs for musculo-skeletal conditions. A review of the literature. Drugs 56: 783-799
40. Wester RC, Maibach HI 1983 Cutaneous pharmacokinetics: 10 steps to percutaneous absorption. Drug Metab Rev 14: 169-205
41. Wester RC, Maibach HI 1992 Percutaneous absorption of drugs. Clin Pharmacokinet 23: 253-266