Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: A potential multitarget vaccine against respiratory infections

Journal of Medicinal Chemistry

Volumn 47, Issue 16, 2004, Pages 3916-3919

  Bay, Sylvie ^a   Huteau, Valérie ^a   Zarantonelli, Maria Leticia ^a   Pires, René ^a   Ughetto Monfrin, Joël ^a   Taha, Muhamed Kheir ^a   England, Patrick ^a   Lafaye, Pierre ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; HAPTEN; M PROTEIN; MENINGOCOCCUS VACCINE; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE PHOSPHORYLCHOLINE CONJUGATE; PHOSPHORYLCHOLINE; PNEUMOCOCCUS VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CONJUGATE; CONTROLLED STUDY; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IC 50; INFECTION PREVENTION; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; RABBIT; RESPIRATORY TRACT INFECTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; VACCINATION;

ACETYLGALACTOSAMINE; ANIMALS; ANTIBODY FORMATION; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; HAPTENS; MICE; NEISSERIA MENINGITIDIS; PHOSPHORYLCHOLINE; RESPIRATORY TRACT INFECTIONS; SERUM ALBUMIN; STREPTOCOCCUS PNEUMONIAE; TETANUS TOXIN;

EID: 3242788771     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040783p     Document Type: Article

References (27)

1. Lipsitch, M. Bacterial vaccines and serotype replacement: lessons from Haemophilus influenzae and prospects for Streptococcus pneumoniae. Emerg. Infect. Dis. 1999, 5, 336-345.
2. Swartley, J. S.; Marfin, A. A.; Edupuganti, S.; Liu, L. J.; Cieslak, P.; Perkins, B.; Wenger, J. D.; Stephens, D. S. Capsule switching of Neisseria meningitidis. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 271-276.
3. Neu, H. C. The crisis in antibiotic resistance. Science 1992, 257, 1064-1073.
4. Casadevall, A.; Scharff, M. Return to the past: the case for antibody-based therapies in infectious diseases. Clin. Infect. Dis. 1995, 21, 150-161.
5. Trolle, S.; Andremont, A.; Fattal, E. Towards a multipurpose vaccination using phosphorylcholine as a unique antigen. STP Pharma. Sci. 1998, 8, 19-30.
6. Cundell, D. R.; Gerard, N. P.; Gerard, C.; Idanpaan-Heikkila, I.; Tuomanen, E. I. Streptococcuspneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 1995, 377, 435-438.
7. Swords, W. E.; Buscher, B. A.; Ver Steeg Ii, K.; Preston, A.; Nichols, W. A.; Weiser, J. N.; Gibson, B. W.; Apicella, M. A. Nontypeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol. Microbiol. 2000, 37, 13-27.
8. Rosenow, C.; Ryan, P.; Weiser, J. N.; Johnson, S.; Fontan, P.; Ortqvist, A.; Masure, H. R. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol. Microbiol. 1997, 25, 819-829.
9. Lysenko, E.; Richards, J. C.; Cox, A. D.; Stewart, A.; Martin, A.; Kapoor, M.; Weiser, J. N. The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing. Mol. Microbiol. 2000, 35, 234-245.
10. Musher, D. M. How contagious are common respiratory tract infections? New Engl. J. Med. 2003, 348, 1256-1266.
11. Briles, D. E.; Forman, C.; Crain, M. Mouse antibody to phosphocholine can protect mice from infection with mouse-virulent human isolates of Streptococcus pneumoniae. Infect. Immun. 1992, 60, 1957-1962.
12. Yother, J.; Forman, C.; Gray, B. M.; Briles, D. E. Protection of mice from infection with Streptococcus pneumoniae by antiphosphocholine antibody. Infect. Immun. 1982, 36, 184-188.
13. Brown, M.; Schumacher, M. A.; Wiens, G. D.; Brennan, R. G.; Rittenberg, M. B. The structural basis of repertoire shift in an immune response to phosphocholine. J. Exp. Med. 2000, 191, 2101-2112.
14. Trolle, S.; Chachaty, E.; Kassis-Chikhani, N.; Wang, C.; Fattal, E.; Couvreur, P.; Diamond, B.; Alonso, J.-M.; Andremont, A. Intranasal immunization with protein-linked phosphorylcholine protects mice against a lethal intranasal challenge with Streptococcus pneumoniae. Vaccine 2000, 18, 2991-2998.
15. Fattal, E.; Pecquet, S.; Couvreur, P.; Andremont, A. Biodegradable microparticles for the mucosal delivery of antibacterial and dietary antigens. Int. J. Pharm. 2002, 242, 15-24.
16. Wallick, S.; Claflin, J. L.; Briles, D. E. Resistance to Streptococcus pneumoniae is induced by a phosphocholine-protein conjugate. J. Immunol. 1983, 130, 2871-2875.
17. Kenny, J. J.; Guelde, G.; Fischer, R. T.; Longo, D. L. Induction of phosphocholine-specific antibodies in X-linked immune deficient mice: in vivo protection against a Streptococcus pneumoniae challenge. Int. Immunol. 1993, 6, 561-568.
18. Fischer, R. T.; Longo, D. L.; Kenny, J. J. A novel phosphocholine antigen protects both normal and X-linked immune deficient mice against Streptococcus pneumoniae. Comparison of the 6-O-phosphocholine hydroxyhexanoate-conjugate with other phosphocholine-containing vaccines. J. Immunol. 1995, 154, 3373-3382.
19. Serino, L.; Virji, M. Phosphorylcholine decoration of lipopolysaccharide differentiates commensal Neisseriae from pathogenic strains: identification of licA·type genes in commensal Neisseriae. Mol. Microbiol. 2000, 35, 1550-1559.
20. Warren, M. J.; Jennings, M. P. Identification and characterization of pptA: a gene involved in the phase-variable expression of phosphorylcholine on pili of Neisseria meningitidis. Infect. Immun. 2003, 71, 6892-6898.
21. Schweda, E. K.; Brisson, J. R.; Alvelius, G.; Martin, A.; Weiser, J. N.; Hood, D. W.; Moxon, E. R.; Richards, J. C. Characterization of the phosphocholine-substituted oligosaccharide in lipopolysaccharides of type b Haemophilus influenzae. Eur. J. Biochem. 2000, 267, 3902-3913.
22. Fischer, W.; Behr, T.; Hartmann, R.; Peter-Katalini, J.; Egge, H. Teichoic acid and lipoteichoic acid of Streptococcus pneumoniae possess identical chain structures. A reinvestigation of teichoid acid (C polysaccharide). Eur. J. Biochem. 1993, 215, 851-857.
23. Karlsson, C.; Jansson, P. E.; Skov Sorensen, U. B. The pneumococcal common antigen C-polysaccharide occurs in different forms. Mono-substituted or di-substituted with phosphocholine. Eur. J. Biochem. 1999, 265, 1091-1097.
24. Qin, H.; Grindley, T. B. Determination of the configuration of ribitol in the C-polysaccharide of Streptococcus pneumoniae using a synthetic approach. Can. J. Chem. 1999, 77, 481-494.
25. Smid, P.; de Zwart, M.; Jörning, W. P. A.; van der Marel, G. A.; van Boom, J. H. Stereoselective synthesis of a tetrameric fragment of Streptococcus pneumoniae type 1 containing an α-linked 2-acetamido-4-amino-2,4,6- trideoxy-D-galactopyranose (SUGp) unit. J. Carbohydr. Chem. 1993, 12, 1073-1090.
26. Bartlett, G. R. Phosphorus assay in column chromatography. J. Biol. Chem. 1958, 234, 466-468.
27. Kolberg, J.; Hoiby, E. A.; Jantzen, E. Detection of the phosphorylcholine epitope in streptococci, Haemophilus and pathogenic Neisseriae by immunoblotting. Microb. Pathog. 1997, 22, 321-329.