Structure-activity relationships for the 9-(pyridin-2'-yl)-aminoacridines

Molecules

Volumn 9, Issue 3, 2004, Pages 102-108

  Mosher, Michael D ^a   Holmes, Kristi L ^a   Frost, Katherine S ^a  

^a UNIVERSITY OF NEBRASKA AT KEARNEY   (United States)

Author keywords

Acridine; DNA; Pyridine; QSAR

Indexed keywords

9 (5' BROMOPYRIDIN 2' YL)AMINOACRIDINE; 9 (5' CHLOROPYRIDIN 2' YL)AMINOACRIDINE; 9 (5' METHYLPYRIDIN 2' YL)AMINOACRIDINE; 9 (5' NITROPYRIDIN 2' YL)AMINOACRIDINE; 9 (PYRIDIN 2' YL)AMINOACRIDINE; AMINOACRIDINE DERIVATIVE; DOUBLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRON TRANSPORT; GENOMICS; NONHUMAN; STRUCTURE ACTIVITY RELATION; THERMAL ANALYSIS; THYMUS;

EID: 3242784771     PISSN: 14203049     EISSN: None     Source Type: Journal    
DOI: 10.3390/90300102     Document Type: Article

References (16)

1. Cancer Facts and Figures, American Cancer Society, 2004, pp 60.
2. Centers for Disease Control, Morbid. Mortal. Rep., 2002, 51, 49.
3. (a) Zittoun, R. Eur. J. Cancer Clin. Oncol., 1985, 21, 649;
4. (b) Atwell, G.J.; Cain, B.F.; Seelye, R.N. J. Med. Chem., 1972, 15, 611.
5. Denny, W.A.; Atwell, G.J.; Cain, B.F. J. Med. Chem., 1979, 22, 1453.
6. Rose, F.L. J. Chem. Soc., 1951, 2770.
7. (a) Chourpa, I.; Manfait, M. J. Raman Spec., 1995, 26, 813;
8. (b) Rowe, T.C.; Chen, G.L.; Hsiang, Y.H.; Liu, L.F. Cancer Res., 1986, 46, 2022;
9. (c) Nelson, E.M.; Tewey, K.M.; Liu, L.F. Proc. Natl. Acad. Sci., 1984, 81, 1361.
10. (a) Jaycox, G.D.; Gribble, G.W.; Hacker, M.P. J. Heterocycl. Chem., 1987, 24, 1405;
11. (b) Wilson, W.R.; Cain, B.F.; Baguley, B.C. Chem Biol. Interactions, 1977, 18, 163.
12. Mosher, M.D.; Johnson, E. Heterocycl. Chem., 2003, 9, in press.
13. Allen, C.F.H.; McKee, G.H.W. Org. Syntheses, Coll. Vol 2, 1943, 15.
14. Albert, A.; Ritchie, B. Org. Syntheses, Coll. Vol 3, 1955, 53.
15. Kuhlmann, K.F.; Charbeneau, N.J.; Mosher, C.W. Nuc. Acids Res., 1978, 5, 2629.
16. + were taken from: C. Hansch, A. Leo, and D. Hoekman, Exploring QSAR: Hydrophobic, Electronic, and Steric Constants; American Chemical Society: Washington, DC, 1995.