Empirical antifungal therapy in treating febrile neutropenic patients

Clinical Infectious Diseases

Volumn 39, Issue SUPPL. 1, 2004, Pages

  Wingard, John R ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; ANTINEOPLASTIC AGENT; CASPOFUNGIN; ECHINOCANDIN B DERIVATIVE; FLUCONAZOLE; ITRACONAZOLE; PYRROLE DERIVATIVE; VORICONAZOLE;

ASPERGILLOSIS; ASPERGILLUS; CANDIDA ALBICANS; CANDIDIASIS; CLINICAL FEATURE; CLINICAL TRIAL; CONFERENCE PAPER; COST; DIAGNOSTIC TEST; DRUG FATALITY; DRUG FORMULARY; FEBRILE NEUTROPENIA; HALLUCINATION; HUMAN; LEUKEMIA; LIVER TOXICITY; MORBIDITY; MORTALITY; MYCOSIS; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; SIDE EFFECT; VISUAL DISORDER;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; CLINICAL TRIALS; DEOXYCHOLIC ACID; DRUG COMBINATIONS; FEVER; FLUCONAZOLE; FUNGEMIA; HUMANS; IMMUNOCOMPROMISED HOST; NEUTROPENIA; OPPORTUNISTIC INFECTIONS;

EID: 3242782339     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/383052     Document Type: Conference Paper

References (16)

1. Pizzo PA, Robichaud KJ, Gill FA, Witebsky FG. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med 1982; 72:101-11.
2. EORTC International Antimicrobial Therapy Cooperative Group. Empiric antifungal therapy in febrile granulocytopenic patients. Am J Med 1989; 86:668-72.
3. Walsh TJ, Finberg RW, Arndt C, et al. Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. N Engl J Med 1999; 340:764-71.
4. White MH, Bowden RA, Sandler ES, et al. Randomized, double-blind clinical trial of amphotericin B colloidal dispersion vs. amphotericin B in the empirical treatment of fever and neutropenia. Clin Infect Dis 1998; 27:296-302.
5. Prentice HG, Hann IM, Herbrecht R, et al. A randomized comparison of liposomal versus conventional amphotericin B for the treatment of pyrexia of unknown origin in neutropenic patients. Br J Haematol 1997; 98:711-8.
6. Wingard JR, White MH, Anaissie E, et al. A randomized, double-blind comparative trial evaluating the safety of liposomal amphotericin B versus amphotericin B lipid complex in the empirical treatment of febrile neutropenia. Clin Infect Dis 2000; 31:1155-63.
7. Fleming RV, Kantarjian HM, Husni R, et al. Comparison of amphotericin B lipid complex vs. Ambisome in the treatment of suspected or documented fungal infections in patients with leukemia. Leuk Lymphoma 2001; 40:511-20.
8. Boogaerts M, Winston DJ, Bow EJ, et al. Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy: a randomized, controlled trial. Ann Intern Med 2001; 135:412-22.
9. Walsh TJ, Pappas P, Winston DJ, et al. Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever. N Engl J Med 2002; 346:225-34.
10. Walsh TJ, Sable C, DePauw B, et al. A randomized, double-blind, multicenter trial of caspofungin vs liposomal amphotericin B for empirical antifungal therapy of persistently febrile neutropenic patients [abstract M1761]. In: Program and abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago). Washington, DC: American Society for Microbiology, 2003.
11. Bennett JE, Powers J, Walsh T, et al. Forum report: issues in clinical trials of empirical antifungal therapy in treating febrile neutropenic patients. Clin Infect Dis 2003; 36(Suppl 3):S117-22.
12. Goodman JL, Winston DJ, Greenfield RA, et al. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med 1992; 326:845-51.
13. Caillot D, Couaillier JF, Bernad A, et al. Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia. J Clin Oncol 2001; 19:253-9.
14. Maertens J, Verhaegen J, Lagrou K, et al. Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. Blood 2001; 97:1604-10.
15. Bennett JE, Kauffman C, Walsh T, et al. Forum report: issues in the evaluation of diagnostic tests, use of historical controls, and merits of the current multicenter collaborative groups. Clin Infect Dis 2003; 36(Suppl 3):S123-7.
16. Lin MT, Lu HC, Chen WL. Improving efficacy of antifungal therapy by polymerase chain reaction-based strategy among febrile patients with neutropenia and cancer. Clin Infect Dis 2001; 33:1621-7.