Preventing peptide-induced anaphylaxis: Addition of C-terminal amino acids to produce a neutral isoelectric point

Journal of Allergy and Clinical Immunology

Volumn 114, Issue 3, 2004, Pages 607-613

  Liu, Edwin ^a,b   Moriyama, Hiroaki ^a   Abiru, Norio ^a   Paronen, Johanna ^a   Devendra, Devasenan ^a   Finkelman, Fred D ^a   Eisenbarth, George S ^a  

^a Box C238 Sch Pharm Univ C   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

allergy; Anaphylaxis; B:9 23; diabetes; immunization; immunotherapy; insulin; Isoelectric point; isoelectric point; NOD; Nonobese diabetic; PAF; peptide; pI; Platelet activating factor; PLP; prevention; Proteolipid protein; vaccine

Indexed keywords

GLUTAMINYLTYROSYLISOLEUCYLLYSYLALANYLASPARAGINYLSERYLLYSYLPHENYLALANYL ISOLEUCYLGLYCYLISOLEUCYLTHREONYLGLUTAMIC ACID; PEPTIDE DERIVATIVE; SERYLHISTIDYLLEUCYLVALYLGLUTAMYLALANYLLEUCYLTYROSYLLEUCYLVALYLCYSTEINYL GLYCYLGLUTAMYLARGINYLGLYCINE; SERYLHISTIDYLLEUCYLVALYLGLUTAMYLALANYLLEUCYLTYROSYLLEUCYLVALYLCYSTEINYL GLYCYLGLUTAMYLARGINYLGLYCYLARGINYLARGININE; SERYLHISTIDYLLEUCYLVALYLGLUTAMYLALANYLLEUCYLTYROSYLLEUCYLVALYLCYSTEINYL GLYCYLGLUTAMYLARGINYLGLYCYLARGINYLARGINYLARGINYLARGININE; UNCLASSIFIED DRUG; VACCINE;

ABSORPTION; ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; ISOELECTRIC POINT; MOUSE; MOUSE STRAIN; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SOLUBILITY;

AMINO ACID SEQUENCE; ANAPHYLAXIS; ANIMALS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNIZATION; INSULIN; ISOELECTRIC POINT; MICE; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS;

EID: 3242762702     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.03.052     Document Type: Article

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