Pain encoding in the human forebrain: Binary and analog exteroceptive channels

Journal of Neuroscience

Volumn 24, Issue 29, 2004, Pages 6540-6544

  Lenz, Fred A ^a   Ohara, Shinji ^a   Gracely, Rick H ^b   Dougherty, Patrick M ^c   Patel, Salil H ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Human; Microstimulation; Pain; Principal sensory nucleus of thalamus; Spinothalamic; Thalamus

Indexed keywords

ARTICLE; ELECTROSTIMULATION; FOREBRAIN; HUMAN; MAJOR CLINICAL STUDY; PAIN; PRIORITY JOURNAL; SENSORY STIMULATION; SPINOTHALAMIC TRACT; THALAMUS; THALAMUS NUCLEUS; VISUAL ANALOG SCALE;

CHRONIC DISEASE; ELECTRIC STIMULATION; HUMANS; MOVEMENT DISORDERS; PAIN; SPINOTHALAMIC TRACTS; THALAMIC NUCLEI;

EID: 3242754493     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1630-04.2004     Document Type: Article

References (36)

1. Apkarian AV, Shi T (1994) Squirrel monkey lateral thalamus. I. Somatic nociresponsive neurons and their relation to spinothalamic terminals. J Neurosci 14:6779-6795.
2. Apkarian AV, Shi T, Bruggemann J, Airapetian LR (2000) Segregation of nociceptive and non-nociceptive networks in the squirrel monkey somatosensory thalamus. J Neurophysiol 84:484-494.
3. Becker DE, Yingling CD, Fein G (1993) Identification of pain, intensity, and P300 components in the pain evoked potential. Electroencephalogr Clin Neurophysiol 88:290-301.
4. Blomqvist A, Zhang ET, Craig AD (2000) Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus, in the human thalamus. Brain 123:601-619.
5. Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C, Buchel C (2002) Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain 125:1326-1336.
6. Bushnell MC, Duncan GH (1987) Mechanical response properties of ventroposterior medial thalamic neurons in the alert monkey. Exp Brain Res 67:603-614.
7. Bushnell MC, Duncan GH, Tremblay N (1993) Thalamic VPM nucleus in the behaving monkey. I. Multimodal and discriminative properties of thermosensitive neurons. J Neurophysiol 69:739-752.
8. Casey KL, Morrow TJ (1983) Ventral posterior thalamic neurons differentially responsive to noxious stimulation of the awake monkey. Science 221:675-677.
9. Chung JM, Lee KH, Surmeier DJ, Sorkin LS, Kim J, Willis WD (1986) Response characteristics of neurons in the ventral posterior lateral nucleus of the monkey thalamus. J Neurophysiol 56:370-390.
10. Coghill RC, Sang CN, Maisog JM, Iadarola MJ (1999) Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol 82:1934-1943.
11. Craig AD (2003a) Pain mechanisms: labeled lines versus convergence in central processing. Annu Rev Neurosci 26:1-30.
12. Craig AD (2003b) A new view of pain as a homeostatic emotion. Trends Neurosci 26:303-307.
13. Craig AD, Bushnell MC, Zhang ET, Blomqvist A (1994) Athalamic nucleus specific for pain and temperature sensation. Nature 372:770-773.
14. Davis KD, Kiss ZH, Luo L, Tasker RR, Lozano AM, Dostrovsky JO (1998) Phantom sensations generated by thalamic microstimulation. Nature 391:385-387.
15. Gracely RH, Lota L, Walter DJ, Dubner R (1988) A multiple random stair-case method of psychophysical pain assessment. Pain 32:55-63.
16. Greenspan JD, Ohara S, Safiani E, Lenz FA (2004) Allodynia inpatients with post-stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals. Pain 109:357-366.
17. Hirai T, Jones EG (1989) A new parcellation of the human thalamus on the basis of histochemical staining. Brain Res Brain Res Rev 14:1-34.
18. Jones EG, Friedman DP, Hendry SH (1982) Thalamic basis of place- and modality-specific columns in monkey somatosensory cortex: a correlative anatomical and physiological study. J Neurophysiol 48:545-568.
19. Lee J, Dougherty PM, Antezana D, Lenz FA (1999) Responses of neurons in the region of human thalamic principal somatic sensory nucleus to mechanical and thermal stimuli graded into the painful range. J Comp Neurol 410:541-555.
20. Lenz FA, Byl NN (1999) Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (ventral caudal) in patients with dystonia. J Neurophysiol 82:3204-3212.
21. Lenz FA, Dostrovsky JO, Tasker RR, Yamashiro K, Kwan HC, Murphy JT (1988) Single-unit analysis of the human ventral thalamic nuclear group: somatosensory responses. J Neurophysiol 59:299-316.
22. Lenz FA, Seike M, Richardson RT, Lin YC, Baker FH, Khoja I, Jaeger CJ, Gracely RH (1993) Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus. J Neurophysiol 70:200-212.
23. Lenz FA, Gracely RH, Rowland LH, Dougherty PM (1994a) Apopulation of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli. Neurosci Lett 180:46-50.
24. Lenz FA, Kwan HC, Martin R, Tasker R, Richardson RT, Dostrovsky JO (1994b) Characteristics of somatotopic organization and spontaneous neuronal activity in the region of the thalamic principal sensory nucleus in patients with spinal cord transection. J Neurophysiol 72:1570-1587.
25. Lenz FA, Gracely RH, Romanoski AJ, Hope EJ, Rowland LH, Dougherty PM (1995) Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. Nat Med 1:910-913.
26. Lenz FA, Gracely RH, Baker FH, Richardson RT, Dougherty PM (1998) Reorganization of sensory modalities evoked by stimulation in the region of the principal sensory nucleus (ventral caudal - Vc) in patients with pain secondary to neural injury. J Comp Neurol 399:125-138.
27. Mayer DJ, Price DD, Becker DP (1975) Neurophysiological characterization of the anterolateral spinal cord neurons contributing to pain perception in man. Pain 1:51-58.
28. Mehler WR (1962) The anatomy of the so-called "pain tract" in man: an analysis of the course and distribution of the ascending fibers of the fasciculus anterolateralis. In: Basic research in paraplegia (French JD, Porter RW, eds), pp 26-55. Springfield, IL: Thomas.
29. Ohara S, Lenz FA (2003) Medial lateral extent of thermal and pain sensations evoked by microstimulation in somatic sensory nuclei of human thalamus. J Neurophysiol 90:2367-2377.
30. Perl ER (1984) Pain and nociception. In: The nervous system: sensory processes, Pt 2 (Brookhart JM, Mountcastle VB, Darian-Smith I, Geiger SR, eds), pp 915-975. Bethesda, MD: American Physiological Society.
31. Price DD, Mayer DJ (1975) Neurophysiological characterization of the anterolateral quadrant neurons subserving pain in M. mulatta. Pain 1:59-72.
32. Price DD, Greenspan JD, Dubner R (2003) Neurons involved in the exteroceptive function of pain. Pain 106:215-219.
33. Ranck JB (1975) Which elements are excited in electrical stimulation of mammalian central nervous system: a review. Brain Res 98:417-440.
34. Willis WD (1985) The pain system. Basel: Karger.
35. Yarnitsky D, Sprecher E (1994) Thermal testing: normative data and repeatability for various test algorithms. J Neurol Sci 125:39-45.
36. Zaslansky R, Sprecher E, Tenke CE, Hemli JA, Yarnitsky D (1995) TheP300 in pain evoked potentials. Pain 66:39-49.