Human hereditary glutathione synthetase deficiency: Kinetic properties of mutant enzymes

Biochemical Journal

Volumn 381, Issue 2, 2004, Pages 489-494

  Njålsson, Runa ^a   Carlsson, Katarina ^a   Bhansali, Vikas ^b   Luo, Jia Li ^c   Nilsson, Lennart ^d   Ladenstein, Rudolf ^d   Anderson, Mary ^e   Larsson, Agne ^a   Norgren, Svante ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF NORTH TEXAS   (United States)

^c Hisun Group Corp Ltd   (China)

^d KAROLINSKA INSTITUTE   (Sweden)

^e TEXAS WOMAN'S UNIVERSITY   (United States)

Author keywords

Co operativity; Glutathione synthetase; Kinetic property; Mutant enzyme; Reaction velocity; Substrate affinity

Indexed keywords

DISEASE CONTROL; ENZYMES; ESCHERICHIA COLI; KINETIC ENERGY; MUTAGENESIS; PATIENT MONITORING;

GLUTATHIONE SYNTHETASE DEFICIENCY; KINETIC PROPERTIES;

BIOCHEMICAL ENGINEERING;

AMINOBUTYRIC ACID DERIVATIVE; GAMMA GLUTAMYL 2 AMINOBUTYRIC ACID; GLUTATHIONE SYNTHASE; LEUCINE; MUTANT PROTEIN; PROLINE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; ENZYME DEFICIENCY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE MUTATION; GENETIC DISORDER; GLUTATHIONE SYNTHASE DEFICIENCY; HUMAN; MISSENSE MUTATION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; WILD TYPE;

AMINO ACID METABOLISM, INBORN ERRORS; GLUTATHIONE SYNTHASE; HUMANS; MODELS, MOLECULAR;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 3242751220     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040114     Document Type: Article

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