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In the case of metha diazirine substituted phenoxy compounds, introduction of the photoaffinity group under basic conditions was reported: a) M. Hashimoto, Y. Hatanaka, and K. Nabeta, Bioorg. Med. Chem. Lett., 12, 89 (2002). b) Y. Hatanaka, M. Hashimoto, and Y. Kanaoka, Bioorg. Med. Chem., 12, 1367 (1994).
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3242803978
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note
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From the resulting compound, the desired photoaffinity labeled sphingomyelin derivative was obtained by phosphorylation, and introduction of acyl and trimethylammonium groups.
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20
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note
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5a
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