Inhibitors of the glycine transporter type-2 (GlyT-2): Synthesis and biological activity of benzoylpiperidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 16, 2004, Pages 4511-4532

  Wolin, Ronald L ^a   Santillán Jr , Alejandro ^a   Tang, Liu ^a   Huang, Charles ^a   Jiang, Xiaoxia ^a   Lovenberg, Timothy W ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[3 [(2 PHENYLAMINOETHYLAMINO)METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 AMINOPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 CYCLOPENTYLOXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 HYDROXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 ISOPROPOXYPHENOXY)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 ISOPROPOXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 ISOPROPOXYPHENYLSULFANYL)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 ISOPROPYLAMINOPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 METHOXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 NITROPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (2 PHENOXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (3 ISOPROPOXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[2 (3 METHOXYPHENYLAMINO)ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[3 (2 ISOPROPOXYPHENOXY)PROPYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[3 (2 ISOPROPOXYPHENYL)PROPYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[3 (2 ISOPROPOXYPHENYLAMINO)PROPYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[[2 (1 ETHYLPROPOXY)PHENYLAMINO]ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[[2 (2 ISOPROPOXYPHENYLAMINO)ETHYL]METHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[[2 (3 ISOPROPOXYPHENYLAMINO)ETHYL]METHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; [3 [[[2 [(2 ISOPROPOXYPHENYL)METHYLAMINO]ETHYL]METHYLAMINO]METHYL]PHENYL] PIPERIDIN 1 YLMETHANONE; [3 [[[2 [(3 ISOPROPOXYPHENYL)METHYLAMINO]ETHYL]METHYLAMINO]METHYL]PHENYL] PIPERIDIN 1 YLMETHANONE; [5 [[2 (2 AMINOPHENYLAMINO)ETHYLAMINO]METHYL]THIOPHEN 3 YL]PIPERIDIN 1 YLMETHANONE; [5 [[2 (2 ISOPROPOXYPHENYLAMINO)ETHYLAMINO]METHYL]THIOPHEN 3 YL]PIPERIDIN 1 YLMETHANONE; [[3 [[2 (2 ISOPROPOXYPHENYL)METHYLAMINO]ETHYLAMINO]METHYL]PHENYL]PIPERIDIN 1 YLMETHANONE; AMINO ACID TRANSPORTER; GLYCINE; N,N DIETHYL 3 [[2 (2 ISOPROPOXYPHENYLAMINO)ETHYLAMINO]METHYL]BENZAMIDE; PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZOIC ACID DERIVATIVE; GLYCINE TRANSPORTER; NEUROTRANSMITTER UPTAKE INHIBITOR;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; BENZOIC ACIDS; BIOLOGICAL TRANSPORT; CERCOPITHECUS AETHIOPS; COS CELLS; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; NEUROTRANSMITTER UPTAKE INHIBITORS; PIPERIDINES;

EID: 3242745973     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.05.044     Document Type: Article

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