Expression of bHLH transcription factors NSCL1 and NSCL2 in the mouse olfactory system

Chemical Senses

Volumn 28, Issue 7, 2003, Pages 603-608

  Suzuki, Yuko ^a   Tsuruga, Eichi ^a   Yajima, Toshihiko ^a   Takeda, Masako ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

In situ hybridization; NSCL1; NSCL2; Olfactory epithelium; Vomeronasal organ

Indexed keywords

HELIX LOOP HELIX PROTEIN; MESSENGER RNA; PROTEIN NSCL1; PROTEIN NSCL2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; NHLH2 PROTEIN, MOUSE; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FETUS; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOMERONASAL ORGAN; ANIMAL; BIOSYNTHESIS; GENE LIBRARY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PREGNANCY;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, NORTHERN; DNA-BINDING PROTEINS; FEMALE; GENE LIBRARY; HELIX-LOOP-HELIX MOTIFS; IN SITU HYBRIDIZATION; MICE; OLFACTORY MUCOSA; OLFACTORY RECEPTOR NEURONS; PREGNANCY; RNA; TRANSCRIPTION FACTORS; VOMERONASAL ORGAN;

EID: 3242739560     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/bjg051     Document Type: Article

References (18)

1. Bae, S.-K., Bessho, Y., Hojo, M. and Kageyama, R. (2000) The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development, 127, 2933-2943.
2. Begley, C.G., Lipkowitz, S., Gobel, V., Mahon, K.A., Bertness, V., Green, A.R., Gough, N.M. and Kirch, I.R. (1992) Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Proc. Natl Acad. Sci. USA, 89, 38-42.
3. Brown, L., Espinosa III, R., Le Beau, M.M., Siciliano, M.J. and Baer, R. (1992) Hen1 and Hen2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc. Natl Acad. Sci. USA, 89, 8492-8496.
4. Cau, E., Gradwohl, G., Fode, C. and Guillemot, F. (1997) Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development, 124, 1611-1621.
5. Cau, E., Gradwohl, G., Casarosa, S., Kageyama, R. and Guillemot, F. (2000) Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development, 127, 2323-2332.
6. Cau, E., Casarosa, S. and Guillemot, F. (2002) Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development, 129, 1871-1880.
7. Farbman, A.I. (1992) Cell Biology of Olfaction. Cambridge University Press, New York.
8. Gobel, V., Lipkowitz, S., Kozak, C.A. and Kirsch, I.R. (1992) NSCL-2: a basic domain helix loop-helix gene expressed in early neurogenesis. Cell Growth Differ., 3, 143-148.
9. Good, D.J., Porter, F.D., Mahon, K.A., Parlow, A.F., Westphal, H. and Kirsch I. R. (1997) Hypogonadism and obesity in mice with a targeted deletion of the Nh1h2 gene. Nature Genet., 15, 397-401.
10. Gordon, M.K., Mumm, J.S., Davis, R.A., Holcomb, J.D. and Calof, A.L. (1995) Dynamics of MASH1 expression in vitro and in vivo suggest a non-stem cell site of MASH1 action in the olfactory receptor neuron lineage. Mol. Cell. Neurosci., 6, 363-379.
11. Haire, M.F. and Chiaramello, A. (1996) Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development. Mol. Brain Res., 36, 174-178.
12. Li, C.-M., Yan, R.-T. and Wang, S.-Z. (1999a) Misexpression of a bHLH gene, cNSCL1, results in abnormal brain development. Dev. Dyn., 215, 238-247.
13. Li, C.-M., Yan, R.-T. and Wang, S.-Z. (1999b) Misexpression of cNSCL1 disrupts retinal development. Mol. Cell. Neurosci., 14, 17-27.
14. Lipkowitz, S., Gobel, V., Varterasian, M.L., Nakahara, K., Tchorz, K. and Kirsch, I.R. (1992) Comparative structural characterization of the human NSCL-1 and NSCL-2 genes. J. Biol. Chem., 267, 21065-21071.
15. Ma, Q., Chen, Z., Barrantes, I., Pompa, J.L. and Anderson, D.J. (1998) Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron, 20, 469-482.
16. Nibu, K., Li, G., Zhang, X., Rawson, N.E., Restrepo, D., Kaga, K., Lowry, L.D., Keane, W. and Rothstein, J. L. (1999) Olfactory neuron-specific expression of NeuroD in mouse and human nasal mucosa. Cell Tissue Res., 298, 405-414.
17. Suzuki, Y., Mizoguchi, I., Nishiyama, H., Takeda, M. and Obara, N. (2003) Expression of Hes6 and NeuroD in the olfactory epithelium, vomeronasal organ and non-sensory patches. Chem. Senses 28, 197-205.
18. Tarozzo, G., Cappello, P., De Andrea, M., Walters, E., Margolis, F.L., Oestreicher, B. and Fasolo, A. (1998) Prenatal differentiation of mouse vomeronasal neurons. Eur. J. Neurosci., 10, 392-396.