A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy

Nephrology Dialysis Transplantation

Volumn 19, Issue 7, 2004, Pages 1895-1901

  Kuypers, Dirk R ^a   Claes, Kathleen ^a   Evenepoel, Pieter ^a   Maes, Bart ^a   Vanrenterghem, Yves ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Haemodialysis; Peritoneal dialysis; Tacrolimus ointment; Uraemic pruritus

Indexed keywords

TACROLIMUS;

ADULT; AGED; ARTICLE; BURNING SENSATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; FEMALE; FOLLOW UP; GLOMERULONEPHRITIS; HEMODIALYSIS; HUMAN; MALE; PERITONEAL DIALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; PYELONEPHRITIS; QUALITY OF LIFE; SCORING SYSTEM; SKIN TINGLING; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; UREMIA; VALIDATION PROCESS; VISUAL ANALOG SCALE;

FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PRURITUS; RENAL DIALYSIS; TACROLIMUS;

EID: 3242734708     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh202     Document Type: Article

References (21)

1. Urbonas A, Schwartz RA, Szepietowski JC. Uremic pruritus - an update. Am J Nephrol 2001; 21: 343-350
2. Young AW, Sweeney EW, David DS et al. Dermatologic evaluation of pruritus in patients on hemodialysis. NY St J Med 1973; 73: 2670-2674
3. Pauli-Magnus C, Mikus G, Alscher DM et al. Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. J Am Soc Nephrol 2000; 11: 514-519
4. Zucker I, Yosipovitch G, David M, Gafter U, Boner G. Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. J Am Acad Dermatol 2003; 49: 842-846
5. Schwartz IF, Iaina A. Management of uremic pruritus. Semin Dial 2000; 13: 177-180
6. Szepietowski JC, Schwartz RA. Uremic pruritus. Int J Dermatol 1998: 37: 247-253
7. Mettang T, Pauli-Magnus C. The pathophysiological puzzle of uremic pruritus - insights and speculations from therapeutic and epidemiological studies. Perit Dial Int 2000; 20: 493-494
8. Mettang T, Pauli-Magnus C, Alscher DM. Uraemic pruritus - new perspectives and insights from recent trials. Nephrol Dial Transplant 2002; 17: 1558-1563
9. Umeuchi H, Togashi Y, Honda T et al. Involvement of central mu-opioid system in scratching behaviour in mice, and the suppression of it by the activation of kappa-opioid system. Eur J Pharmacol 2003; 477: 29-35
10. Andersen LW, Friedberg M, Lokkegaard N. Naloxone in treatment of uremic pruritus: a case history. Clin Nephrol 1984; 21: 355-356
11. Peer G, Kivity S, Agami O et al. Randomized crossover trial of naltrexone in uraemic pruritus. Lancet 1996; 348: 1552-1554
12. Togashi Y, Umeuchi H, Okana K et al. Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. Eur J Pharmacol 2002; 435: 259-264
13. Garssen J, Vandebriel RJ, DeGruijl FR et al. UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses. Immunology 1999; 97: 506-514
14. Silva SRB, Viana PCF, Lugon NV, Hoette M, Ruzany F, Lugon JR. Thalidomide for the treatment of uremic pruritus: a crossover randomised double-blind trial. Nephron 1994; 67: 270-273
15. Venkataramanan R, Swaminathan A, Prasad T et al. Clinical pharmacokinetics of tacrolimus. Clin Pharmacokinet 1995; 29: 404-430
16. Pauli-Magnus C, Klumpp S, Aischer DM, Kuhlmann U, Mettang T. Short-term efficacy of tacrolimus ointment in severe uremic pruritus. Perit Dial Int 2000; 20: 802-803
17. Goodwin CL, Finkelstain JI, Madden MR. Burns. In: Shwartz SI, Shires GT, Spencer FC, eds, Principles of Surgery. McGraw Hill, New York; 1994: 230
18. Daugirdas JT. Simplified equations for monitoring Kt/V, PCRn, eKt/V, and ePCRn. Adv Ren Replace Ther 1995; 2: 295-304
19. Morton CA, Lafferty M, Hau C, Henderson I, Jones M, Lowe JG. Pruritus and skin hydration during dialysis. Nephrol Dial Transplant 1996; 11: 2031-2036
20. Ashmore SD, Jones CH, Newstead CG, Daly MJ, Chrystyn H. Ondansetron therapy for uremic pruritis in hemodialysis patients. Am J Kidney Dis 2000; 35: 827-831
21. Cho YL, Liu HN, Huang TP, Tarng DC. Uremic pruritus: roles of parathyroid hormone and substance P. J Am Acad Dermatol 1997; 36: 538-543