Differential diagnosis and management of thrombocytopenia in childhood

Pediatric Clinics of North America

Volumn 51, Issue 4, 2004, Pages 1109-1140

  Kaplan, Rosandra N ^a   Bussel, James B ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; CARBAMAZEPINE; CITALOPRAM; DESMOPRESSIN ACETATE; HEPARIN; IMMUNOGLOBULIN; METHYLPREDNISOLONE; NEUROLEPTIC AGENT; OLANZAPINE; PAROXETINE; PENICILLIN G; PREDNISONE; PSYCHOTROPIC AGENT; RIFAMPICIN; SEROTONIN UPTAKE INHIBITOR; SULFONAMIDE; VALPROIC ACID; VANCOMYCIN;

ASPHYXIA; CATARACT; CHILDHOOD DISEASE; CLINICAL EXAMINATION; CLINICAL FEATURE; DRUG INDUCED DISEASE; FANCONI ANEMIA; GROUPS BY AGE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE DEFICIENCY; JUVENILE RHEUMATOID ARTHRITIS; MAY HEGGLIN ANOMALY; MOOD DISORDER; NECROTIZING ENTEROCOLITIS; OSTEOPOROSIS; PATHOPHYSIOLOGY; REVIEW; SEPSIS; SIDE EFFECT; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TRISOMY 13; TRISOMY 18; TRISOMY 21; VON WILLEBRAND DISEASE; WEIGHT GAIN; WISKOTT ALDRICH SYNDROME;

BLOOD COAGULATION DISORDERS, INHERITED; BLOOD PLATELETS; CHILD; DIAGNOSIS, DIFFERENTIAL; HUMANS; INFANT, NEWBORN; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; THROMBOCYTOPENIA;

EID: 3242733263     PISSN: 00313955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcl.2004.03.008     Document Type: Review

References (48)

1. Bartley T., Bogenberger J., Hunt P., Li Y.S., Lu H.S, Martin F., et al. Identification and cloning of a megakaryocyte growth and development factor, (MGDF) which is a ligand for MPL. Cell. 77:1994;1117-1124
2. Dame C. Thrombopoietin in Thrombocytopenias of childhood. Semin Thromb Hemost. 27(3):2001;215-218
3. Sainio S., Jarvenpaa A.L., Renlund M., Riikonen S., Teramo K., Kekomaki R. Thrombocytopenia in term infants: a population-based study. Obstet Gynecol. 95(3):2000;441-446
4. Jaegtvik S., Husebekk A., Aune B., Oian P., Dahl L.B., Skogen B. Neonatal alloimmune thrombocytopenia due to anti-HPA 1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn. Br J Obstet Gynaecol. 107(5):2000;691-694
5. a) as determined by antenatal screening. Blood. 92:1998;2280-2287
6. Bussel J.B., Zacharoulis S., Kramer K., McFarland J., Pauliny J., Kaplan C., and the Neonatal Alloimmune Thrombocytopenia Registry Group. Clinical and diagnostic features of neonatal alloimmune thrombocytopenia: comparison to non-immune cases of thrombocytopenia. Pediatr Blood Cancer 2003, in press
7. Flug F., Karpatkin M., Karpatkin S. Should all pregnant women be tested for their platelet PLA (Zw, HPA-1) phenotype? Br J Haematol. 86(1):1994;1-5
8. Sainio S., Javela K., Kekomaki R., Teramo K. Thrombopoietin levels in cord blood plasma and amniotic fluid in fetuses with alloimmune thrombocytopenia and healthy controls. Br J Haematol. 109(2):2000;330-335
9. Porcelijn L., Folman C.C., de Haas M., Kanhai H.H., Murphy M.F., von dem Borne A.E., et al. Fetal and neonatal thrombopoietin levels in alloimmune thrombocytopenia. Pediatr Res. 52(1):2002;105-108
10. Bussel J.B. Alloimmune thrombocytopenia in the fetus and newborn. Semin Thromb Hemost. 27(3):2001;245-252
11. Bussel J.B., Berkowitz R.L., Lynch L., Lesser M.L., Paidas M.J., Huang C.L., et al. Antenatal management of alloimmune thrombocytopenia with intravenous gammaglobulin: a randomized trial of the addition of low dose steroids to IVIG in fifty-five maternal-fetal pairs. Am J Obstet Gynecol. 174(5):1996;1414-1423
12. Bussel J.B., Druzin M.L., Cines D.B., Samuels P. Thrombocytopenia in pregnancy. Lancet. 337(8735):1991;251
13. Ballin A., Andrew M., Ling E., Perlman M., Blanchette V. High-dose intravenous gammaglobulin therapy for neonatal autoimmune thrombocytopenia. J Pediatr. 112(5):1988;789-792
14. Burrows R.F., Kelton J.G. Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med. 329(20):1993;1463-1466
15. Cook R.L., Miller R.C., Katz V.L., Cefalo R.C. Immune thrombocytopenic purpura in pregnancy: a reappraisal of management. Obstet Gynecol. 78(4):1991;578-583
16. Watts T.L., Murray N.A., Roberts I.A. Thrombopoietin has a primary role in the regulation of platelet production in preterm babies. Pediatr Res. 46(1):1999;28-32
17. Sola M.C., Calhoun D.A., Hutson A.D., Christensen R.D. Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit. Br J Haematol. 104(1):1999;90-92
18. Colarizi P., Fiorucci P., Caradonna A., Ficuccilli F., Mancuso M., Papoff P. Circulating thrombopoietin levels in neonates with infection. Acta Paediatr. 88(3):1999;332-337
19. Hohlfeld P., Forestier F., Kaplan C., Tissot J.D., Daffos F. Fetal thrombocytopenia: a retrospective survey of 5,194 fetal blood samplings. Blood. 84(6):1994;1851-1856
20. Roth G.J. Developing relationships: arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins. Blood. 77(1):1991;5-19
21. Kelley M.J., Jawien W., Ortel T.L., Korczak J.F. Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. Nat Genet. 26(1):2000;106-108
22. Okita J.R., Frojmovic M.M., Kristopeit S., Wong T., Kunicki T.J. Montreal platelet syndrome: a defect in calcium-activated neutral proteinase (calpain). Blood. 74(2):1989;715-721
23. Fleischman R.A., Letestu R., Mi X., Stevens D., Winters J., Debili N., et al. Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome. Br J Haematol. 116(2):2002;367-375
24. Thompson A.A., Nguyen L.T. Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. Nat Genet. 26(4):2000;397-398
25. Ballmaier M., Schulze H., Strauss G., Cherkaoui K., Wittner N., Lynen S., et al. Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin. Blood. 90(2):1997;612-619
26. al-Jefri A.H., Dror Y., Bussel J.B., Freedman M.H. Thrombocytopenia with absent radii: frequency of marrow megakaryocyte progenitors, proliferative characteristics, and megakaryocyte growth and development factor responsiveness. Pediatr Hematol Oncol. 17(4):2000;299-306
27. Fadoo Z., Naqvi S.M. Acute myeloid leukemia in a patient with thrombocytopenia with absent radii syndrome. J Pediatr Hematol Oncol. 24(2):2002;134-135
28. Calpin C., Dick P., Poon A., Feldman W. Is bone marrow aspiration needed in acute childhood idiopathic thrombocytopenic purpura to rule out leukemia? Arch Pediatr Adolesc Med. 152(4):1998;345-347
29. McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin Hematol. 37(3):2000;239-248
30. Olsson B., Andersson P.O., Jernas M., Jacobsson S., Carlsson B., Carlsson L.M., et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 9(9):2003;1123-1124
31. Woerner S.J., Abildgaard C.F., French B.N. Intracranial hemorrhage in children with idiopathic thrombocytopenic purpura. Pediatrics. 67(4):1981;453-460
32. Medeiros D., Buchanan G.R. Current controversies in the management of idiopathic thrombocytopenic purpura during childhood. Pediatr Clin North Am. 43(3):1996;757-772
33. Brenner B., Guilburd J.N., Tatarsky I., Doron Y., Goldsher D. Spontaneous intracranial hemorrhage in immune thrombocytopenic purpura. Neurosurgery. 22(4):1988;761-764
34. Medeiros D., Buchanan G.R. Current controversies in the management of idiopathic thrombocytopenic purpura during childhood. Pediatr Clin North Am. 43(3):1996;757-772
35. Di Paola J.A., Buchanan G.R. Immune thrombocytopenic purpura. Pediatr Clin North Am. 49(5):2002;911-928
36. Klaassen R.J., van der Lelie J., Vlekke A.B., Weigel H.M., Eeftinck Schattenkerk J.K., Reiss P., et al. The serology and immunochemistry of HIV-induced platelet-bound immunoglobulin. Blut. 59(1):1989;75-81
37. Ellaurie M., Burns E.R., Bernstein L.J., Shah K., Rubinstein A. Thrombocytopenia and human immunodeficiency virus in children. Pediatrics. 82(6):1988;905-908
38. Bottiger L.E., Furhoff A.K., Holmberg L. Drug-induced blood dyscrasias. A ten-year material from the Swedish Adverse Drug Reaction Committee. Acta Medica Scandinavica. 205(6):1979;457-461
39. Anonymous Adverse Drug React Bull. 21(3):2000;161-166
40. Vandel P., Vandel S., Kantelip J.P. SSRI-induced bleeding: two case reports. Therapie. 56(4):2001;445-447
41. Committee on Safety of Medicines Heparin-induced thrombocytopenia. Current Problems. 28:1990
42. Hach-Wunderle V., Kainer K., Krug B., Muller-Berghaus G., Potzsch B. Heparin-associated thrombosis despite normal platelet counts. Lancet. 344(8920):1994;469-470
43. Levy G.G., Nichols W.C., Lian E.C., Foroud T., McClintick J.N., McGee B.M., et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature. 413(6855):2001;488-494
44. Tsai H.M. Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura. J Am Soc Nephrol. 14(4):2003;1072-1081
45. Tsai H.M. Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura. J Am Soc Nephrol. 14(4):2003;1072-1081
46. Cremer M., Schulze H., Linthorst G., Folman C.C., Wehnert S., Strauss G., et al. Serum levels of thrombopoietin, IL-11, and IL-6 in pediatric thrombocytopenias. Ann Hematol. 78(9):1999;401-407
47. Albayrak D., Islek I., Kalayci A.G., Gurses N. Acute immune thrombocytopenic pupura: A comparative study of very high oral doses of methylprednisolone and intravenously administered immune globulin. J Pediatr. 125:1994;1004-1007
48. Wiley J.M., Luddy R.E., Bussel J.B. Abstract in blood efficiency and safety of Rituxan treatment in children with chronic immune thrombocytopenia purpura. Blood. 102(11):2004;297a