Protective effects of mutant ubiquitin in transgenic mice

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 215-218

  Gray, D A ^a   Tsirigotis, M ^a   Brun, J ^a   Tang, M ^a   Zhang, M ^a   Beyers, M ^a   Woulfe, J ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

K48R; Life span; Mice; Mutant; Transgenic; Ubiquitin

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CISPLATIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; UBIQUITIN;

AGING; CONFERENCE PAPER; CYTOKINE RELEASE; DNA DAMAGE; DNA REPAIR; ENDOPLASMIC RETICULUM; GENETIC CODE; IN VIVO STUDY; INFECTION; LIFESPAN; MAMMAL CELL; METHODOLOGY; MONITORING; MOUSE; MOUSE STRAIN; MUTANT; MUTATION; NONHUMAN; PARAMETER; PROTECTION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN METABOLISM; TRANSGENIC MOUSE; VIRUS REPLICATION; WILD TYPE;

BACTERIA (MICROORGANISMS); MAMMALIA; MUS MUSCULUS;

EID: 3242732994     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.035     Document Type: Conference Paper

References (10)

1. GRAY, D.A., M. TSIRIGOTIS & J. WOULFE. 2003. Ubiquitin, proteasomes, and the aging brain. Sci. Aging Knowl. Environ. 2003: RE6.
2. FINLEY, D. et al. 1994. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol. Cell. Biol. 14: 5501-5509.
3. SPENCE, J. et al. 1995. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol. Cell. Biol. 15: 1265-1273.
4. TSIRIGOTIS, M. et al. 2001. Analysis of ubiquitination in vivo using a transgenic mouse model. Biotechniques 31: 120-126, 128, 130.
5. TSIRIGOTIS, M. et al. 2001. Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents. J. Biol. Chem. 276: 46073-46078.
6. ZHANG, M. et al. 2003. Effects of mutant ubiquitin on ts1 retrovirus-mediated neuropathology. J. Virol. 77: 7193-7201.
7. SEARS, C. et al. 1998. NF-kappa B p105 processing via the ubiquitin-proteasome pathway. J. Biol. Chem. 273: 1409-1419.
8. DENG, L. et al. 2000. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361.
9. ADAMS, J. 2001. Proteasome inhibition in cancer: development of PS-341. Semin. Oncol. 28: 613-619.
10. RASOULPOUR, R.J. et al. 2003. Altered ubiquitination protects the testis from cryptorchid injury and aging. Am. J. Pathol. In press.