Analysis of the enantiomers of VX using normal-phase chiral chromatography with atmospheric pressure chemical ionization-mass spectrometry

Journal of Analytical Toxicology

Volumn 28, Issue 5, 2004, Pages 390-392

  Smith, J Richard ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHORUS COMPOUND;

ARTICLE; ATMOSPHERIC PRESSURE; CHEMICAL ANALYSIS; CHEMICAL WARFARE; CHIRALITY; CHOLINESTERASE INHIBITION; ENANTIOMER; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; STEREOSPECIFICITY;

EID: 3242729443     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/28.5.390     Document Type: Article

References (8)

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2. H.P. Benschop and L.P.A. De Jong. Nerve agent stereoisomers: analysis, isolation, and toxicology. Acc. Chem. Res. 21: 368-374 (1988).
3. J.R. Smith and J.J. Schlager. Gas chromatographic separation of the stereoisomers of organophosphorus chemical warfare agents using cyclodextrin capillary columns. J. High Resol. Chromatogr. 19: 151-154 (1996).
4. C.E. Kientz, J.P. Langenberg, and U.A.T. Brinkman. Microcolumn liquid chromatography with thermionic detection of the enantiomers of O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate (VX). J. High Resol. Chromatogr. 17: 95-97 (1994).
5. J.R. Smith and M.L. Shih. Analysis of the stereoisomers of the organophosphorus chemical warfare agent VX using chiral LC and APCI mass spectrometry. In Proceedings of the 47th ASMS Conference on Mass Spectrometry and Applied Topics, Dallas, TX, June 13-17, 1999, pp 3048-3049.
6. M.J. van der Schans, B.J. Lander, H. van der Wiel, J.P. Langenberg, and H.P. Benschop. Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol. Appl. Pharmacol. 191: 48-62 (2003).
7. E. Bonierbale, L. Debordes, and L. Coppet. Application of capillary gas chromatography to the study of hydrolysis of the nerve agent VX in rat plasma. J. Chromatogr. B 688: 255-264 (1997).
8. J. Epstein, J.J. Callahan, and V.E. Bauer. The kinetics and mechanisms of hydrolysis of phosphonothiolates in dilute aqueous solution. Phosphorus 4: 157-163 (1974).