Alternative pathways might mediate toxicity of high concentrations of superoxide dismutase

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 370-374

  Kowald, Axel ^a   Klipp, Edda ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

Aging; Antioxidants; Free radicals; Transgenics

Indexed keywords

COPPER; HYDROXYL RADICAL; SUPEROXIDE DISMUTASE; ZINC;

CONCENTRATION RESPONSE; CONFERENCE PAPER; ENZYME MECHANISM; MATHEMATICAL MODEL; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PEROXIDATION; PROTEIN EXPRESSION;

ANIMALIA;

EID: 3242718600     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.065     Document Type: Conference Paper

References (9)

1. SINET, P.M. 1982. Metabolism of oxygen derivatives in Down's syndrome. Ann. N.Y. Acad. Sci. 396: 83-94.
2. BROOKSBANK, B.W.L. & R. BALAZS. 1984. Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Down's syndrome fetal brain. Dev. Brain Res. 16: 37.
3. ORR, W.C. & R.S. SOHAL. 1993. Effects of Cu-Zn superoxide dismutase overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch. Biochem. Biophys. 301: 34-40.
4. REVEILLAUD, I. et al. 1991. Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance to oxidative stress. Mol. Cell. Biol. 11: 632-640.
5. SCOTT, M.D., S.R. MESHNICK & J.W. EATON. 1987. Superoxide dismutase rich bacteria. Paradoxidal increase in oxidant toxicity. J. Biol. Chem. 262: 3640-3645.
6. SIWECKI, G. & O.R. BROWN. 1990. Overproduction of superoxide dismutase does not protect Escherichia coli from stringency-induced growth inhibition by 1 mM paraquat. Biochem. Int. 20: 191-200.
7. LIOCHEV, S.I. & I. FRIDOVICH. 2000. Copper- and zinc-containing superoxide dismutase can act as a superoxide reductase and a superoxide oxidase. J. Biol. Chem. 275: 38482-38485.
8. NELSON, S.K., S.K. BOSE & J.M. MCCORD. 1994. The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart. Free Radic. Biol. Med. 16: 195-200.
9. YIM, M.B., P.B. CHOCK & E.R. STADTMAN. 1993. Enzyme function of copper, zinc superoxide dismutase as a free radical generator. J. Biol. Chem. 268: 4099-4105.