The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration

Drug Metabolism and Drug Interactions

Volumn 20, Issue 1-2, 2004, Pages 1-10

  Roopnarinsingh, E S ^a   Steventon, G B ^b   Harris, R M ^c   Waring, R H ^c   Mitchell, S C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

D penicillamine; L cysteine; Metabolism; Rat; S carboxymethyl L cysteine; Sulphate

Indexed keywords

AMINO ACID; ANTIRHEUMATIC AGENT; CARBOCISTEINE; CYSTEINE; PENICILLAMINE; SULFUR 35; VALINE;

ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DEGRADATION; DRUG METABOLISM; ISOTOPE LABELING; MALE; NONHUMAN; RADIOACTIVITY; RAT; URINARY EXCRETION;

EID: 3242688116     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2004.20.1-2.1     Document Type: Article

References (30)

1. th Ed, Vol. II. London: Cradock and Joy, 1815; 352.
2. Halliburton WD. A Text-Book of Chemical Physiology and Pathology. London: Longmans, Green and Co., 1891; 740-746, 760-761.
3. Morris ME, Murer H. Molecular mechanisms in renal and intestinal sulfate (re)absorption. J Memb Biol 2001; 181: 1-9.
4. Markovich D. Physiological roles and regulation of mammalian sulfate transporters. Physiol Rev 2001; 81: 1499-1533.
5. Osman LP, Mitchell SC, Waring RH. Cysteine, its metabolism and toxicity. Sulfur Rep 1997; 20: 155-172.
6. Jocelyn PC. Biochemistry of the SH Group. London: Academic Press, 1972; 170-173.
7. rd Ed. VII. Metabolism of Sulphur Compounds. London: Academic Press, 1975; 535-546.
8. Mitchell SC, Waring RH. The early history of xenobiotic sulfoxidation. Drug Metab Rev 1985/86; 16: 255-284.
9. Pilkington AE, Waring RH. The metabolism and disposition of D-penicillamine in the DA-strain rat. Eur J Drug Metab Pharmacokinet 1988; 13: 99-104.
10. Pilkington AE, Waring RH. D-Penicillamine metabolism: in vivo studies of S-oxidation mechanisms. Drug Metab Drug Interact 1988; 6: 85-93.
11. Waring RH. The metabolism of S-carboxymethylcysteine in rodents, marmosets and humans. Xenobiotics 1978; 8: 265-270.
12. Waring RH, Mitchell SC. The metabolism and elimination of S-carboxymethyl-L-cysteine in man. Drug Metab Dispos 1982; 10: 61-62.
13. Mitchell SC, Waring RH. Detection of inorganic sulphate and other anions on paper and thin-layer chromatograms. J Chromatogr 1978; 166: 341-343.
14. Pilkington AE, Waring RH. The determination of inorganic sulphate levels in biological fluids using HPLC techniques. Med Sci Res 1988; 16: 35-36.
15. Bourke CE, Miners JO, Birkett DJ. Reversible metabolism of D-penicillamine in the rat. Drug Metab Dispos 1984; 12: 798-799.
16. 14C-D-Penicillamin an Ratten. Arzneim Forsch 1977; 27: 1152-1158.
17. Planas-Bohn F. Metabolism and pharmacokinetics of penicillamine in rats - an overview. J Rheumatol 1981; 8: 35-40.
18. Ruiz-Torres A, Kurten I. Zur Pharmakokinetik und zum Sotffweatisel von E- und L-Penicillamin. Arzneim Forsch 1974; 24: 1258-1261.
19. Servin A. Demonstration of an entero-hepatic cycle for S-carboxymethyl-L-cysteine. Compte Rendu Soc Biol (Paris) 1977; 171: 39-42.
20. Bodmer JG, Waring RH. Tissue distribution of S-carboxymethyl-L-cysteine in the rat - concentration in mucus-producing organs including the prostate. Biochem Soc Trans 1981; 9: 549-550.
21. Waring RH. The metabolism of S-carboxymethylcysteine in rodents, marmosets and humans. Xenobiotica 1978; 8: 265-270.
22. Turnbull LE, Teng L, Kinzie JM, Pitts JE, Pinchbeck FM, Bruce RB. Excretion and biotransformation of carboxymethylcysteine in rat, dog, monkey and man. Xenobiotica 1978; 8: 621-628.
23. Mavromichalis I, Kerr BJ, Parr TM, Albin DM, Gabert VM, Baker DH. Valine requirements in nursery pigs. J Anim Sci 2001; 79: 1223-1229.
24. +-dependent L-valine uptake in jejunum of streptozotocin-diabetic rats. Eur J Clin Invest 1990; 20: 61-65.
25. Planas JM, Gonzalez E, Ferrer R, Moreto, M. Transport of L-valine by the chicken caecum. Br Poult Sci 1997; 38: 307-310.
26. Mitchell SC, Waring RH. S-Oxygenases, III: Human pharmacogenetics. In: Damani LA, ed. Sulphur-containing Drugs and Related Organic Compounds. Chichister: Ellis Horwood Ltd., 1989; Vol 2A, 101-119.
27. Benincosa LJ, Sagawa K, Morris ME. Renal adaptation to altered dietary sulphate in rats. J Pharmacol Exp Ther 1995; 272: 248-255.
28. Connor WJ. Tubular reabsorption in normal renal function. Ren Physiol 1984; 7: 193-204.
29. Murer H, Biber J. Cellular mechanisms in renal tubular transport of divalent inorganic anions. Nephrologie 1996; 17: 365-369.
30. Beck L, Silve C. Molecular aspects of renal tubular handling and regulation of inorganic sulphate. Kidney Int 2001; 59: 835-845.