메뉴 건너뛰기




Volumn 33, Issue 3, 2004, Pages 525-544

Management of atherogenic dyslipidemia of the metabolic syndrome: Evolving rationale for combined drug therapy

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTILIPEMIC AGENT; APOLIPOPROTEIN B; ATORVASTATIN; BEZAFIBRATE; CIPROFIBRATE; CLOFIBRATE; FATTY ACID; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MEVINOLIN; NICOTINIC ACID; PRAVASTATIN; SIMVASTATIN; STANOL ESTER;

EID: 3242664106     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2004.03.013     Document Type: Review
Times cited : (13)

References (75)
  • 1
    • 0035897696 scopus 로고    scopus 로고
    • ATP. III Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 285:2001;2486-2497
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 2
    • 0027220709 scopus 로고
    • Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol
    • Blades B., Vega G.L., Grundy S.M. Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol. Arterioscler Thromb. 13:(8):1993;1227-1235
    • (1993) Arterioscler Thromb , vol.13 , Issue.8 , pp. 1227-1235
    • Blades, B.1    Vega, G.L.2    Grundy, S.M.3
  • 3
    • 0028942298 scopus 로고
    • Relation between cholesterol ester transfer protein activities and lipoprotein cholesterol in patients with hypercholesterolemia and combined hyperlipidemia
    • Tato F., Vega G.L., Tall A.R., Grundy S.M. Relation between cholesterol ester transfer protein activities and lipoprotein cholesterol in patients with hypercholesterolemia and combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 15:(1):1995;112-120
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , Issue.1 , pp. 112-120
    • Tato, F.1    Vega, G.L.2    Tall, A.R.3    Grundy, S.M.4
  • 4
    • 0031028793 scopus 로고    scopus 로고
    • Determinants of plasma HDL-cholesterol in hypertriglyceridemic patients. Role of cholesterol-ester transfer protein and lecithin cholesteryl acyl transferase
    • Tato F., Vega G.L., Grundy S.M. Determinants of plasma HDL-cholesterol in hypertriglyceridemic patients. Role of cholesterol-ester transfer protein and lecithin cholesteryl acyl transferase. Arterioscler Thromb Vasc Biol. 17:(1):1997;56-63
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , Issue.1 , pp. 56-63
    • Tato, F.1    Vega, G.L.2    Grundy, S.M.3
  • 5
    • 0034277627 scopus 로고    scopus 로고
    • High-density lipoprotein metabolism: Molecular targets for new therapies for atherosclerosis
    • Kawashiri M.A., Maugeais C., Rader D.J. High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis. Curr Atheroscler Rep. 2:(5):2000;363-372
    • (2000) Curr Atheroscler Rep , vol.2 , Issue.5 , pp. 363-372
    • Kawashiri, M.A.1    Maugeais, C.2    Rader, D.J.3
  • 6
    • 0035985725 scopus 로고    scopus 로고
    • Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells
    • Barter P.J., Baker P.W., Rye K.A. Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells. Curr Opin Lipidol. 13:(3):2002;285-288
    • (2002) Curr Opin Lipidol , vol.13 , Issue.3 , pp. 285-288
    • Barter, P.J.1    Baker, P.W.2    Rye, K.A.3
  • 7
    • 0027763632 scopus 로고
    • Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase
    • Mackness M.I., Arrol S., Abbott C.A., Durrington P.N. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis. 104:1993;129-135
    • (1993) Atherosclerosis , vol.104 , pp. 129-135
    • MacKness, M.I.1    Arrol, S.2    Abbott, C.A.3    Durrington, P.N.4
  • 8
    • 0033301270 scopus 로고    scopus 로고
    • Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins
    • Aviram M. Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins. Antioxid Redox Signal. 1:(4):1999;585-594
    • (1999) Antioxid Redox Signal , vol.1 , Issue.4 , pp. 585-594
    • Aviram, M.1
  • 9
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med. 340:(2):1999;115-126
    • (1999) N Engl J Med , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 10
    • 0023147156 scopus 로고
    • Secretory products of macrophages
    • Nathan C.F. Secretory products of macrophages. J Clin Invest. 79:(2):1987;319-326
    • (1987) J Clin Invest , vol.79 , Issue.2 , pp. 319-326
    • Nathan, C.F.1
  • 11
    • 0027435542 scopus 로고
    • The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation
    • Mackness M.I., Abbott C., Arrol S., Durrington P.N. The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation. Biochem J. 294:(Pt 3):1993;829-834
    • (1993) Biochem J , vol.294 , Issue.3 PART , pp. 829-834
    • MacKness, M.I.1    Abbott, C.2    Arrol, S.3    Durrington, P.N.4
  • 12
    • 0032723117 scopus 로고    scopus 로고
    • High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL
    • Xia P., Vadas M.A., Rye K.A., Barter P.J., Gamble J.R. High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL. J Biol Chem. 274:(46):1999;33143-33147
    • (1999) J Biol Chem , vol.274 , Issue.46 , pp. 33143-33147
    • Xia, P.1    Vadas, M.A.2    Rye, K.A.3    Barter, P.J.4    Gamble, J.R.5
  • 13
    • 0032908549 scopus 로고    scopus 로고
    • Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells
    • Baker P.W., Rye K.A., Gamble J.R., Vadas M.A., Barter P.J. Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells. J Lipid Res. 40:(2):1999;345-353
    • (1999) J Lipid Res , vol.40 , Issue.2 , pp. 345-353
    • Baker, P.W.1    Rye, K.A.2    Gamble, J.R.3    Vadas, M.A.4    Barter, P.J.5
  • 14
    • 0035423181 scopus 로고    scopus 로고
    • ACCESS Study Group. Atorvastatin Comparative Cholesterol Efficacy and Safety Study. Correlation of non-high-density lipoprotein cholesterol with apolipoprotein B: Effect of 5 hydroxymethylglutaryl coenzyme a reductase inhibitors on non-high-density lipoprotein cholesterol levels
    • Ballantyne C.M., Andrews T.C., Hsia J.A., Kramer J.H., Shear C. ACCESS Study Group. Atorvastatin Comparative Cholesterol Efficacy and Safety Study. Correlation of non-high-density lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on non-high-density lipoprotein cholesterol levels. Am J Cardiol. 88:(3):2001;265-269
    • (2001) Am J Cardiol , vol.88 , Issue.3 , pp. 265-269
    • Ballantyne, C.M.1    Andrews, T.C.2    Hsia, J.A.3    Kramer, J.H.4    Shear, C.5
  • 15
    • 0028078733 scopus 로고
    • Quantification of cholesterol in all lipoprotein classes by the VAP-II method
    • Kulkarni K.R., Garber D.W., Marcovina S.M., Segrest J.P. Quantification of cholesterol in all lipoprotein classes by the VAP-II method. J Lipid Res. 35:(1):1994;159-168
    • (1994) J Lipid Res , vol.35 , Issue.1 , pp. 159-168
    • Kulkarni, K.R.1    Garber, D.W.2    Marcovina, S.M.3    Segrest, J.P.4
  • 16
    • 0026644250 scopus 로고
    • Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement
    • Otvos J.D., Jeyarajah E.J., Bennett D.W., Krauss R.M. Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement. Clin Chem. 38:1992;1632-1638
    • (1992) Clin Chem , vol.38 , pp. 1632-1638
    • Otvos, J.D.1    Jeyarajah, E.J.2    Bennett, D.W.3    Krauss, R.M.4
  • 17
    • 0017658853 scopus 로고
    • Measurement of plasma lipoproteins by electrophoresis on polyacrylamide gel
    • Muniz N. Measurement of plasma lipoproteins by electrophoresis on polyacrylamide gel. Clin Chem. 23:(10):1977;1826-1833
    • (1977) Clin Chem , vol.23 , Issue.10 , pp. 1826-1833
    • Muniz, N.1
  • 18
    • 0032743737 scopus 로고    scopus 로고
    • Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes
    • Mahley R.W., Huang Y., Rall S.C. Jr. Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res. 40:(11):1999;1933-1949
    • (1999) J Lipid Res , vol.40 , Issue.11 , pp. 1933-1949
    • Mahley, R.W.1    Huang, Y.2    Rall Jr., S.C.3
  • 19
    • 0015796295 scopus 로고
    • Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
    • Goldstein J.L., Schrott H.G., Hazzard W.R., Bierman E.L., Motulsky A.G. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest. 52:(7):1973;1544-1568
    • (1973) J Clin Invest , vol.52 , Issue.7 , pp. 1544-1568
    • Goldstein, J.L.1    Schrott, H.G.2    Hazzard, W.R.3    Bierman, E.L.4    Motulsky, A.G.5
  • 20
    • 0035204807 scopus 로고    scopus 로고
    • Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: A 20-year prospective study
    • McNeely M.J., Edwards K.L., Marcovina S.M., Brunzell J.D., Motulsky A.G., Austin M.A. Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: a 20-year prospective study. Atherosclerosis. 159:(2):2001;471-481
    • (2001) Atherosclerosis , vol.159 , Issue.2 , pp. 471-481
    • McNeely, M.J.1    Edwards, K.L.2    Marcovina, S.M.3    Brunzell, J.D.4    Motulsky, A.G.5    Austin, M.A.6
  • 21
    • 0021709906 scopus 로고
    • Low density lipoprotein metabolism in familial combined hyperlipidemia. Mechanism of the multiple lipoprotein phenotypic expression
    • Kissebah A.H., Alfarsi S., Evans D.J. Low density lipoprotein metabolism in familial combined hyperlipidemia. Mechanism of the multiple lipoprotein phenotypic expression. Arteriosclerosis. 4:(6):1984;614-624
    • (1984) Arteriosclerosis , vol.4 , Issue.6 , pp. 614-624
    • Kissebah, A.H.1    Alfarsi, S.2    Evans, D.J.3
  • 22
    • 0025992946 scopus 로고
    • Influence of lovastatin therapy on metabolism of low density lipoproteins in mixed hyperlipidaemia
    • Vega G.L., Grundy S.M. Influence of lovastatin therapy on metabolism of low density lipoproteins in mixed hyperlipidaemia. J Intern Med. 230:(4):1991;341-350
    • (1991) J Intern Med , vol.230 , Issue.4 , pp. 341-350
    • Vega, G.L.1    Grundy, S.M.2
  • 23
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • Ford E.S., Giles W.H., Dietz W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 287:(3):2002;356-359
    • (2002) JAMA , vol.287 , Issue.3 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 24
    • 0035193079 scopus 로고    scopus 로고
    • PPARS, metabolic disease and atherosclerosis
    • Fruchart J.C., Staels B., Duriez P. PPARS, metabolic disease and atherosclerosis. Pharmacol Res. 44:(5):2001;345-352
    • (2001) Pharmacol Res , vol.44 , Issue.5 , pp. 345-352
    • Fruchart, J.C.1    Staels, B.2    Duriez, P.3
  • 25
    • 3142623027 scopus 로고    scopus 로고
    • The cardioprotective effects of statins
    • Davignon J. The cardioprotective effects of statins. Curr Atheroscler Rep. 6:(1):2004;27-35
    • (2004) Curr Atheroscler Rep , vol.6 , Issue.1 , pp. 27-35
    • Davignon, J.1
  • 26
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 344:1994;1383-1389
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 27
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Sacks F.M., Pfeffer M.A., Moye L.A., Rouleau J.L., Rutherford J.D., Cole T.G., et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 335:1996;1001-1009
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3    Rouleau, J.L.4    Rutherford, J.D.5    Cole, T.G.6
  • 28
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 339:1998;1349-1357
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 29
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
    • Shepherd J., Cobbe S.M., Ford I., Isles C.G., Lorimer A.R., MacFarlane P.W., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 333:1995;1301-1307
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    MacFarlane, P.W.6
  • 30
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Downs M. Jr., Clearfield S., Weis E., Whitney D.R., Shapiro P.A., Beere A., et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 279:1998;1615-1622
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs Jr., M.1    Clearfield, S.2    Weis, E.3    Whitney, D.R.4    Shapiro, P.A.5    Beere, A.6
  • 31
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 360:2002;7-22
    • (2002) Lancet , vol.360 , pp. 7-22
  • 33
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
    • Rubins H.B., Robins S.J., Collins D., Fye C.L., Anderson J.W., Elam M.B., et al., for the Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N Engl J Med. 341:1999;410-418
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6
  • 34
    • 0035941990 scopus 로고    scopus 로고
    • Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study
    • Diabetes Atherosclerosis Intervention Study Investigators. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet. 357:2001;905-910
    • (2001) Lancet , vol.357 , pp. 905-910
  • 36
    • 0030463802 scopus 로고    scopus 로고
    • Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease
    • Kontopoulos A.G., Athyros V.G., Papageorgiou A.A., Hatzikonstandinou H.A., Mayroudi M.C., Boudoulas H. Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease. Coron Artery Dis. 7:1996;843-850
    • (1996) Coron Artery Dis , vol.7 , pp. 843-850
    • Kontopoulos, A.G.1    Athyros, V.G.2    Papageorgiou, A.A.3    Hatzikonstandinou, H.A.4    Mayroudi, M.C.5    Boudoulas, H.6
  • 37
    • 0023926816 scopus 로고
    • Combination drug therapy for familial combined hyperlipidemia
    • East C., Bilheimer D.W., Grundy S.M. Combination drug therapy for familial combined hyperlipidemia. Ann Intern Med. 109:1988;25-32
    • (1988) Ann Intern Med , vol.109 , pp. 25-32
    • East, C.1    Bilheimer, D.W.2    Grundy, S.M.3
  • 39
    • 0030954159 scopus 로고    scopus 로고
    • Long-term treatment with pravastatin alone and in combination with gemfibrozil in familial type IIB hyperlipoproteinemia or combined hyperlipidemia
    • Napoli C., Lepore S., Chiariello P., Condorelli M., Chiariello M. Long-term treatment with pravastatin alone and in combination with gemfibrozil in familial type IIB hyperlipoproteinemia or combined hyperlipidemia. J Cardiovasc Pharmacol Ther. 2:(1):1997;17-26
    • (1997) J Cardiovasc Pharmacol Ther , vol.2 , Issue.1 , pp. 17-26
    • Napoli, C.1    Lepore, S.2    Chiariello, P.3    Condorelli, M.4    Chiariello, M.5
  • 40
    • 0037446467 scopus 로고    scopus 로고
    • Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome
    • Vega G.L., Vega G.L., Ma P.T., Cater N.B., Filipchuk N., Meguro S., et al. Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome. Am J Cardiol. 91:(8):2003;956-960
    • (2003) Am J Cardiol , vol.91 , Issue.8 , pp. 956-960
    • Vega, G.L.1    Vega, G.L.2    Ma, P.T.3    Cater, N.B.4    Filipchuk, N.5    Meguro, S.6
  • 41
    • 0028343587 scopus 로고
    • Combined treatment with pravastatin and gemfibrozil in patients with refractory familial combined hyperlipidemia: A clinical study
    • Athyros V.G., Papageorgiou A.A., Hagikonstantinou H.J., Papadopoulos G.V., Zamboulis C.X., Kontopoulos A.G. Combined treatment with pravastatin and gemfibrozil in patients with refractory familial combined hyperlipidemia: a clinical study. Drug Invest. 7:(3):1994;134-142
    • (1994) Drug Invest , vol.7 , Issue.3 , pp. 134-142
    • Athyros, V.G.1    Papageorgiou, A.A.2    Hagikonstantinou, H.J.3    Papadopoulos, G.V.4    Zamboulis, C.X.5    Kontopoulos, A.G.6
  • 42
    • 0026636425 scopus 로고
    • Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias
    • Glueck C.J., Oakes N., Speirs J., Tracy T., Lang J. Gemfibrozil- lovastatin therapy for primary hyperlipoproteinemias. Am J Cardiol. 70:1992;1-9
    • (1992) Am J Cardiol , vol.70 , pp. 1-9
    • Glueck, C.J.1    Oakes, N.2    Speirs, J.3    Tracy, T.4    Lang, J.5
  • 43
    • 0025309850 scopus 로고
    • Safety and efficacy of combined gemfibrozil-lovastatin therapy for primary dyslipoproteinemias
    • Glueck C.J., Speirs J., Tracy T. Safety and efficacy of combined gemfibrozil-lovastatin therapy for primary dyslipoproteinemias. J Lab Clin Med. 115:1990;603-609
    • (1990) J Lab Clin Med , vol.115 , pp. 603-609
    • Glueck, C.J.1    Speirs, J.2    Tracy, T.3
  • 44
    • 0032923831 scopus 로고    scopus 로고
    • Randomized crossover study of gemfibrozil versus lovastatin in familial combined hyperlipidemia: Additive effects of combination treatment on lipid regulation
    • Zambon D., Ros E., Rodriguez-Villar C., Laguna J.C., Vazquez M., Sanllehy C., et al. Randomized crossover study of gemfibrozil versus lovastatin in familial combined hyperlipidemia: additive effects of combination treatment on lipid regulation. Metabolism. 48:(1):1999;47-54
    • (1999) Metabolism , vol.48 , Issue.1 , pp. 47-54
    • Zambon, D.1    Ros, E.2    Rodriguez-Villar, C.3    Laguna, J.C.4    Vazquez, M.5    Sanllehy, C.6
  • 45
    • 0027298781 scopus 로고
    • Treatment of severe, resistant familial combined hyperlipidemia with a bezafibrate-lovastatin combination
    • Yeshurun D., Abukarshin R., Elias N., Lanir A., Naschitz J.E. Treatment of severe, resistant familial combined hyperlipidemia with a bezafibrate-lovastatin combination. Clin Ther. 15:1993;355-363
    • (1993) Clin Ther , vol.15 , pp. 355-363
    • Yeshurun, D.1    Abukarshin, R.2    Elias, N.3    Lanir, A.4    Naschitz, J.E.5
  • 46
    • 0028273352 scopus 로고
    • Comparative efficacy and safety of micronized fenofibrate and simvastatin in patients with primary type IIa or IIb hyperlipidemia
    • Farnier M., Bonnefous F., Debbas N., Irvine A. Comparative efficacy and safety of micronized fenofibrate and simvastatin in patients with primary type IIa or IIb hyperlipidemia. Arch Intern Med. 154:1994;441-449
    • (1994) Arch Intern Med , vol.154 , pp. 441-449
    • Farnier, M.1    Bonnefous, F.2    Debbas, N.3    Irvine, A.4
  • 47
    • 0032788490 scopus 로고    scopus 로고
    • Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders
    • Murdock D.K., Murdock A.K., Murdock R.W., Olson K.J., Frane A.M., Kersten M.E., et al. Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders. Am Heart J. 138:1999;151-155
    • (1999) Am Heart J , vol.138 , pp. 151-155
    • Murdock, D.K.1    Murdock, A.K.2    Murdock, R.W.3    Olson, K.J.4    Frane, A.M.5    Kersten, M.E.6
  • 48
    • 0025315986 scopus 로고
    • Management of primary mixed hyperlipidemia with lovastatin
    • Vega G.L., Grundy S.M. Management of primary mixed hyperlipidemia with lovastatin. Arch Intern Med. 150:(6):1990;1313-1319
    • (1990) Arch Intern Med , vol.150 , Issue.6 , pp. 1313-1319
    • Vega, G.L.1    Grundy, S.M.2
  • 49
    • 0032959122 scopus 로고    scopus 로고
    • Long-term safety of pravastatin-gemfibrozil therapy in mixed hyperlipidemia
    • Iliadis E.A., Rosenson R.S. Long-term safety of pravastatin-gemfibrozil therapy in mixed hyperlipidemia. Clin Cardiol. 22:(1):1999;25-28
    • (1999) Clin Cardiol , vol.22 , Issue.1 , pp. 25-28
    • Iliadis, E.A.1    Rosenson, R.S.2
  • 50
    • 0032714726 scopus 로고    scopus 로고
    • Combined hyperlipidemia is associated with increased exercise-induced muscle protein release which is improved by triglyceride-lowering intervention
    • Smit J.W., De Bruin T.W., Eekhoff E.M., Glatz J., Erkelens D.W. Combined hyperlipidemia is associated with increased exercise-induced muscle protein release which is improved by triglyceride-lowering intervention. Metabolism. 48:(12):1999;1518-1523
    • (1999) Metabolism , vol.48 , Issue.12 , pp. 1518-1523
    • Smit, J.W.1    De Bruin, T.W.2    Eekhoff, E.M.3    Glatz, J.4    Erkelens, D.W.5
  • 51
    • 0033997559 scopus 로고    scopus 로고
    • Efficacy and tolerability of fluvastatin and bezafibrate in patients with hyperlipidemia and persistently high triglyceride levels
    • Spieker L.E., Noll G., Hannak M., Luscher T.F. Efficacy and tolerability of fluvastatin and bezafibrate in patients with hyperlipidemia and persistently high triglyceride levels. J Cardiovasc Pharm. 35:2000;361-365
    • (2000) J Cardiovasc Pharm , vol.35 , pp. 361-365
    • Spieker, L.E.1    Noll, G.2    Hannak, M.3    Luscher, T.F.4
  • 52
    • 0002474897 scopus 로고
    • Addition of fibrates to simvastatin therapy in hyperlipidemia patients
    • Deslypere J.P. Addition of fibrates to simvastatin therapy in hyperlipidemia patients. Atherosclerosis. 97:1992;S67-S71
    • (1992) Atherosclerosis , vol.97
    • Deslypere, J.P.1
  • 53
    • 0033153214 scopus 로고    scopus 로고
    • Atatin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease
    • Papadakis J.A., Ganotakis E.S., Jagroop I.A., Winder A.F., Mikhailidis D.P. Atatin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease. Int J Cardiol. 69:1999;237-244
    • (1999) Int J Cardiol , vol.69 , pp. 237-244
    • Papadakis, J.A.1    Ganotakis, E.S.2    Jagroop, I.A.3    Winder, A.F.4    Mikhailidis, D.P.5
  • 54
    • 0024603055 scopus 로고
    • Gemfibrozil alone and in combination with lovastatin for treatment of hypertriglyceridemia in NIDDM
    • Garg A., Grundy S.M. Gemfibrozil alone and in combination with lovastatin for treatment of hypertriglyceridemia in NIDDM. Diabetes. 38:(3):1989;364-372
    • (1989) Diabetes , vol.38 , Issue.3 , pp. 364-372
    • Garg, A.1    Grundy, S.M.2
  • 55
    • 0038637253 scopus 로고    scopus 로고
    • Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia
    • Wagner A.M., Wagner A.M., Jorba O., Bonet R., Ordonez-Llanos J., Perez A. Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia. J Clin Endocrinol Metab. 88:(7):2003;3212-3217
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.7 , pp. 3212-3217
    • Wagner, A.M.1    Wagner, A.M.2    Jorba, O.3    Bonet, R.4    Ordonez-Llanos, J.5    Perez, A.6
  • 56
    • 0032542388 scopus 로고    scopus 로고
    • Effect of niacin on atherosclerotic cardiovascular disease
    • [discussion: 39U-41U]
    • Guyton J.R. Effect of niacin on atherosclerotic cardiovascular disease. Am J Cardiol. 82:(12A):1998;18U-23U. [discussion: 39U-41U]
    • (1998) Am J Cardiol , vol.82 , Issue.12 A
    • Guyton, J.R.1
  • 57
    • 0033751381 scopus 로고    scopus 로고
    • Mechanism of action of niacin on lipoprotein metabolism
    • Kamanna V.S., Kashyap M.L. Mechanism of action of niacin on lipoprotein metabolism. Curr Atheroscler Rep. 2:(1):2000;36-46
    • (2000) Curr Atheroscler Rep , vol.2 , Issue.1 , pp. 36-46
    • Kamanna, V.S.1    Kashyap, M.L.2
  • 59
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson L.A., Rosenhamer G. Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand. 223:(5):1988;405-418
    • (1988) Acta Med Scand , vol.223 , Issue.5 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 61
    • 0025183769 scopus 로고
    • Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
    • Brown G., Albers J.J., Fisher L.D., Schaefer S.M., Lin J.T., Kaplan C., et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med. 323:(19):1990;1289-1298
    • (1990) N Engl J Med , vol.323 , Issue.19 , pp. 1289-1298
    • Brown, G.1    Albers, J.J.2    Fisher, L.D.3    Schaefer, S.M.4    Lin, J.T.5    Kaplan, C.6
  • 62
    • 0025685469 scopus 로고
    • Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens
    • Kane J.P., Malloy M.J., Ports T.A., Phillips N.R., Diehl J.C., Havel R.J. Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens. JAMA. 264:(23):1990;3007-3012
    • (1990) JAMA , vol.264 , Issue.23 , pp. 3007-3012
    • Kane, J.P.1    Malloy, M.J.2    Ports, T.A.3    Phillips, N.R.4    Diehl, J.C.5    Havel, R.J.6
  • 63
    • 0030746239 scopus 로고    scopus 로고
    • Moderate dose, three-drug therapy with niacin, lovastatin, and colestipol to reduce low-density lipoprotein cholesterol <100 mg/dl in patients with hyperlipidemia and coronary artery disease
    • Brown B.G., Bardsley J., Poulin D., Hillger L.A., Dowdy A., Maher V.M., et al. Moderate dose, three-drug therapy with niacin, lovastatin, and colestipol to reduce low-density lipoprotein cholesterol <100 mg/dl in patients with hyperlipidemia and coronary artery disease. Am J Cardiol. 80:(2):1997;111-115
    • (1997) Am J Cardiol , vol.80 , Issue.2 , pp. 111-115
    • Brown, B.G.1    Bardsley, J.2    Poulin, D.3    Hillger, L.A.4    Dowdy, A.5    Maher, V.M.6
  • 64
    • 0028012746 scopus 로고
    • Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia
    • Davignon J., Roederer G., Montigny M., Hayden M.R., Tan M.H., Connelly P.W., et al. Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia. Am J Cardiol. 73:(5):1994;339-345
    • (1994) Am J Cardiol , vol.73 , Issue.5 , pp. 339-345
    • Davignon, J.1    Roederer, G.2    Montigny, M.3    Hayden, M.R.4    Tan, M.H.5    Connelly, P.W.6
  • 66
    • 0028527139 scopus 로고
    • Complementary effects of pravastatin and nicotinic acid in the treatment of combined hyperlipidaemia in diabetic and non-diabetic patients
    • Tsalamandris C., Panagiotopoulos S., Sinha A., Cooper M.E., Jerums G. Complementary effects of pravastatin and nicotinic acid in the treatment of combined hyperlipidaemia in diabetic and non-diabetic patients. J Cardiovasc Risk. 1:(3):1994;231-239
    • (1994) J Cardiovasc Risk , vol.1 , Issue.3 , pp. 231-239
    • Tsalamandris, C.1    Panagiotopoulos, S.2    Sinha, A.3    Cooper, M.E.4    Jerums, G.5
  • 67
    • 0029076712 scopus 로고
    • Comparison of lovastatin (20 mg) and nicotinic acid (1.2 g) with either drug alone for type II hyperlipoproteinemia
    • Vacek J.L., Dittmeier G., Chiarelli T., White J., Bell H.H. Comparison of lovastatin (20 mg) and nicotinic acid (1.2 g) with either drug alone for type II hyperlipoproteinemia. Am J Cardiol. 76:(3):1995;182-184
    • (1995) Am J Cardiol , vol.76 , Issue.3 , pp. 182-184
    • Vacek, J.L.1    Dittmeier, G.2    Chiarelli, T.3    White, J.4    Bell, H.H.5
  • 68
    • 0029066170 scopus 로고
    • Effects of pravastatin with niacin or magnesium on lipid levels and postprandial lipemia
    • O'Keefe J.H. Jr., Harris W.S., Nelson J., Windsor S.L. Effects of pravastatin with niacin or magnesium on lipid levels and postprandial lipemia. Am J Cardiol. 76:(7):1995;480-484
    • (1995) Am J Cardiol , vol.76 , Issue.7 , pp. 480-484
    • O'keefe Jr., J.H.1    Harris, W.S.2    Nelson, J.3    Windsor, S.L.4
  • 69
    • 0029894370 scopus 로고    scopus 로고
    • Combination therapy with low-dose lovastatin and niacin is as effective as higher-dose lovastatin
    • Gardner S.F., Schneider E.F., Granberry M.C., Carter I.R. Combination therapy with low-dose lovastatin and niacin is as effective as higher-dose lovastatin. Pharmacotherapy. 16:(3):1996;419-423
    • (1996) Pharmacotherapy , vol.16 , Issue.3 , pp. 419-423
    • Gardner, S.F.1    Schneider, E.F.2    Granberry, M.C.3    Carter, I.R.4
  • 70
    • 0030917574 scopus 로고    scopus 로고
    • Combination of low-dose niacin and pravastatin improves the lipid profile in diabetic patients without compromising glycemic control
    • Gardner S.F., Gardner S.F., Marx M.A., White L.M., Granberry M.C., Skelton D.R., et al. Combination of low-dose niacin and pravastatin improves the lipid profile in diabetic patients without compromising glycemic control. Ann Pharmacother. 31:(6):1997;677-682
    • (1997) Ann Pharmacother , vol.31 , Issue.6 , pp. 677-682
    • Gardner, S.F.1    Gardner, S.F.2    Marx, M.A.3    White, L.M.4    Granberry, M.C.5    Skelton, D.R.6
  • 71
    • 0030268441 scopus 로고    scopus 로고
    • Effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and "normal" cholesterol levels. A randomized, placebo-controlled trial. Harvard Atherosclerosis Reversibility Project (HARP) Study Group
    • Pasternak R.C., Brown L.E., Stone P.H., Silverman D.I., Gibson C.M., Sacks F.M. Effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and "normal" cholesterol levels. A randomized, placebo-controlled trial. Harvard Atherosclerosis Reversibility Project (HARP) Study Group. Ann Intern Med. 125:(7):1996;529-540
    • (1996) Ann Intern Med , vol.125 , Issue.7 , pp. 529-540
    • Pasternak, R.C.1    Brown, L.E.2    Stone, P.H.3    Silverman, D.I.4    Gibson, C.M.5    Sacks, F.M.6
  • 72
    • 0037086184 scopus 로고    scopus 로고
    • Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia
    • Kashyap M.L., McGovern M.E., Berra K., Guyton J.R., Kwiterovich P.O., Harper W.L., et al. Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia. Am J Cardiol. 89:2002;672-678
    • (2002) Am J Cardiol , vol.89 , pp. 672-678
    • Kashyap, M.L.1    McGovern, M.E.2    Berra, K.3    Guyton, J.R.4    Kwiterovich, P.O.5    Harper, W.L.6
  • 73
    • 0025148561 scopus 로고
    • Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus
    • Garg A., Grundy S.M. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA. 264:(6):1990;723-726
    • (1990) JAMA , vol.264 , Issue.6 , pp. 723-726
    • Garg, A.1    Grundy, S.M.2
  • 74
    • 0037158150 scopus 로고    scopus 로고
    • Diabetes Multicenter Research Group. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: Results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial
    • Grundy S.M., Vega G.L., McGovern M.E., Tulloch B.R., Kendall D.M., Fitz-Patrick D., et al. Diabetes Multicenter Research Group. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial. Arch Intern Med. 162:(14):2002;1568-1576
    • (2002) Arch Intern Med , vol.162 , Issue.14 , pp. 1568-1576
    • Grundy, S.M.1    Vega, G.L.2    McGovern, M.E.3    Tulloch, B.R.4    Kendall, D.M.5    Fitz-Patrick, D.6
  • 75
    • 0041330631 scopus 로고    scopus 로고
    • Free fatty acid metabolism during fenofibrate treatment of the metabolic syndrome
    • Vega G.L., Cater N.B., Hadizadeh D.R. 3rd, Meguro S., Grundy S.M. Free fatty acid metabolism during fenofibrate treatment of the metabolic syndrome. Clin Pharmacol Ther. 74:(3):2003;236-244
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.3 , pp. 236-244
    • Vega, G.L.1    Cater, N.B.2    Hadizadeh III, D.R.3    Meguro, S.4    Grundy, S.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.