Pregnancy-associated plasma protein A, free β-hCG, nuchal translucency, and risk of pregnancy loss

Obstetrics and Gynecology

Volumn 104, Issue 1, 2004, Pages 30-36

  Goetzl, Laura ^a   Krantz, David ^a   Simpson, Joe Leigh ^a   Silver, Richard K ^a   Zachary, Julia M ^a   Pergament, Eugene ^a   Platt, Lawrence D ^a   Mahoney, Maurice J ^a   Wapner, Ronald J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; FETUS ECHOGRAPHY; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MATERNAL AGE; MATERNAL SERUM; MULTICENTER STUDY; PATIENT SELECTION; PREGNANCY LOSS; PREGNANCY TERMINATION; PRENATAL SCREENING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RACE; RISK; VAGINA BLEEDING; BLOOD; CLINICAL TRIAL; ECHOGRAPHY; NECK; PREGNANCY; PRENATAL DEVELOPMENT; SPONTANEOUS ABORTION;

ABORTION, SPONTANEOUS; ADULT; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; COHORT STUDIES; FEMALE; GESTATIONAL AGE; HUMANS; NECK; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; ULTRASONOGRAPHY, PRENATAL;

EID: 3242661793     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000129969.78308.4f     Document Type: Article

References (16)

1. Wald NJ, Rodeck C, Hackshaw AK, Walters J, Chitty L, Mackinson AM. First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS). J Med Screen 2003;10:56-104.
2. Wapner R, Thom E, Simpson JL, Pergament E, Silver R, Filkins K, et al. First-trimester screening for trisomies 21 and 18. N Engl J Med 2003;349:1405-13.
3. Spencer K, Spencer CE, Power M, Dawson C, Nicolaides KH. Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years prospective experience. BJOG 2003;110:281-6.
4. Haddow JE, Palomaki GE, Knight GJ, Williams J, Miller WA, Johnson A. Screening of maternal serum for fetal Down's syndrome in the first trimester. N Engl J Med 1998;338:955-61.
5. Crossley JA, Aitken DA, Cameron AD, McBride E, Connor JM. Combined ultrasound and biochemical screening for Down's syndrome in the first trimester: a Scottish multicentre study. BJOG 2002;109:667-76.
6. Schuchter K, Hafner E, Stangl G, Metzenbauer M, Hofinger D, Philipp K. The first trimester "combined test" for the detection of Down syndrome pregnancies in 4939 unselected pregnancies. Prenat Diag 2002;22:211-5.
7. von Kaisenberg CS, Gasiorek-Wiens A, Bielicki M, Bahlmann F, Meyberg H, Kossakiewicz A, et al, for the German Speaking Down Syndrome Screening Group. Screening for trisomy 21 by maternal age, fetal nuchal translucency and maternal serum biochemistry at 11-14 weeks: a German multicenter study. J Matern Fetal Neonatal Med 2002;12: 89-94.
8. Westergaard JG, Sinosich MJ, Bugge M, Madsen LT, Teisner B, Grudzinskas JG. Pregnancy-associated plasma protein A in the prediction of early pregnancy failure. Am J Obstet Gynecol 1983;145:67-9.
9. Christodoulou CN, Zonas C, Loukaides T, Maniatis A, Giannikos L, Giannakopoulos C, et al. Low beta-hCG is associated with poor prognosis in association with an embryo with positive cardiac activity. Ultrasound Obstet Gynecol 1995;5:267-70.
10. Ruge S, Pedersen JF, Sorensen S, Lange AP. Can pregnancy-associated plasma protein A (PAPP-A) predict the outcome of pregnancy in women with threatened abortion and confirmed fetal viability? Acta Obstet Gynecol Scand 1990;69:589-95.
11. Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. BJOG 2000; 107:1265-70.
12. Yaron Y, Heifetz S, Ochshorn Y, Lehavi O, Orr-Urtreger A. Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenat Diag 2002;22:778-82.
13. Yaron Y, Ochshorn Y, Heifetz S, Lehavi O, Sapir Y, Orr-Urtreger A. First trimester maternal serum free human chorionic gonadotropin as a predictor of adverse pregnancy outcome. Fetal Diag Ther 2002;17:352-6.
14. Smith GC, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM. Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrin Metab 2002;87:1762-7.
15. Li TC, Spring PG, Bygrave C, Laird SM, Serle E, Spuijbroek M, Adekanmi O. The value of biochemical and ultrasound measurements in predicting pregnancy outcome in women with a history of recurrent miscarriage. Hum Reprod 1998; 13:3525-9.
16. Simpson JL, Mills JL, Holmes LB, Ober CL, Aarons J, Jovanovic L, et al. Low fetal loss rates after ultrasound-proved viability in early pregnancy. JAMA 1987;258:2555-7.