Assessment and modulation of acamprosate intestinal absorption: Comparative studies using in situ, in vitro (CACO-2 cell monolayers) and in vivo models

European Journal of Pharmaceutical Sciences

Volumn 22, Issue 5, 2004, Pages 347-356

  Zornoza, Teodoro ^a   Cano Cebrián, María José ^a   Nalda Molina, Ricardo ^a   Guerri, Consuelo ^b   Granero, Luis ^a   Polache, Ana ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Acamprosate; Bioavailability; Enhancement; Intestinal absorption; Paracellular

Indexed keywords

ACAMPROSATE; DECANOATE SODIUM; POLYSORBATE 80; SODIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG TRANSPORT; DRUG URINE LEVEL; EXPERIMENT; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; INTESTINE ABSORPTION; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE; ELECTRIC IMPEDANCE; HUMANS; INTESTINAL ABSORPTION; MALE; RATS; RATS, WISTAR; TAURINE;

EID: 3242659717     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.04.004     Document Type: Article

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