Correlation of circulating tumor cells with tumor size and metastatic load in a spontaneous lung metastasis model

Anticancer Research

Volumn 24, Issue 3 A, 2004, Pages 1421-1425

  Katoh, M ^a   Neumaier, M ^a   Nezam, R ^a   Izbicki, J R ^a   Schumacher, U ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Carcinoembryonic antigen (CEA); Circulating tumor cells; Colon cancer cell line HT29; Metastasis model; PCR; Severe combined immunodeficient (scid) mouse

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER TRANSPLANTATION; CELL COUNT; CELL STRAIN HT29; CELL SURVIVAL; CIRCULATION; COLON CARCINOMA; CONTROLLED STUDY; CORRELATION FUNCTION; HUMAN; HUMAN CELL; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SCID MOUSE; TARGET ORGAN; TUMOR CELL; TUMOR VOLUME;

ANIMALS; HT29 CELLS; HUMANS; K562 CELLS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; NEOPLASM CIRCULATING CELLS;

EID: 3242658232     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Weiss L: Inefficiency of metastasis from colorectal carcinomas. Relationship to local therapy for hepatic metastasis. Cancer Treat Res 69: 1-11, 1994.
2. Jung R, Petersen K, Kruger W, Wolf M, Wagener C, Zander A and Neumaier M: Detection of micrometastasis by cytokeratin 20 RT-PCR is limited due to stable background transcription in granulocytes. Br J Cancer 81: 870-3, 1999.
3. Kruger W, Jung R, Kroger N, Gutensohn K, Fiedler W, Neumaier M, Janicke F, Wagener C and Zander AR: Sensitivity of assays designed for the detection of disseminated epithelial tumor cells is influenced by cell separation methods. Clin Chem 46: 435-6, 2000.
4. Mitchell BS and Schumacher U: Use of immunodeficient mice in metastasis research. Br J Biomed Sci 54: 278-86, 1997.
5. Schumacher U and Adam E: Lectin histochemical HPA-binding pattern of human breast and colon cancers is associated with metastases formation in severe combined immunodeficient mice. Histochem J 29: 677-84, 1997.
6. Ikeda Y, Mori M, Adachi Y, Matsushima T and Sugimachi K: Prognostic value of the histochemical expression of helix pomatia agglutinin in advanced colorectal cancer. A univariate and multivariate analysis. Dis Colon Rectum 37: 181-4, 1994.
7. Jojovic M and Schumacher U: Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. Cancer Lett 152: 151-6, 2000.
8. Gerhard M, Juhl H, Kalthoff H, Schreiber HW, Wagener C and Neumaier M: Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol 12: 725-9, 1994.
9. Thompson JA, Grunert F and Zimmermann W: Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 5: 344-66, 1991.
10. Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarstrom S, Holmes KV, Karlsson A, Kuroki M, Lin SH, Lucka L, Najjar SM, Neumaier M, Obrink B, Shively JE, Skubitz KM, Stanners CP, Thomas P, Thompson JA, Virji M, von Kleist S, Wagener C, Watt S and Zimmermann W: Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 252: 243-9, 1999.
11. Chelly J, Concordet JP, Kaplan JC and Kahn A: Illegitimate transcription: transcription of any gene in any cell type. Proc Natl Acad Sci USA 86: 2617-21, 1989.
12. Jung R, Kruger W, Hosch S, Holweg M, Kroger N, Gutensohn K, Wagener C, Neumaier M and Zander AR: Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro. Br J Cancer 78: 1194-8, 1998.
13. Fjellbirkeland L, Laerum OD, Eide GE and Bjerkvig R: Invasiveness by lacZ transfected non-small-cell lung cancer cells into human bronchial tissues in vitro. Lung Cancer 21: 7-19, 1998.
14. Jung R, Ahmad-Nejad P, Wimmer M, Gerhard M, Wagener C and Neumaier M: Quality management and influential factors for the detection of single metastatic cancer cells by reverse transcriptase polymerase chain reaction. Eur J Clin Chem Clin Biochem 35: 3-10, 1997.