Shiga toxins present in the gut and in the polymorphonuclear leukocytes circulating in the blood of children with hemolytic-uremic syndrome

Journal of Clinical Microbiology

Volumn 44, Issue 2, 2006, Pages 313-317

  Brigotti, Maurizio ^a,g   Caprioli, Alfredo ^b   Tozzi, Alberto E ^c   Tazzari, Pier Luigi ^d   Ricci, Francesca ^d   Conte, Roberto ^d   Carnicelli, Domenica ^a   Procaccino, Maria Antonietta ^c   Minelli, Fabio ^b   Ferretti, Alfonso V S ^e   Paglialonga, Fabio ^f   Edefonti, Alberto ^f   Rizzoni, Gianfranco ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

^f Clinica Pediatrica De Marchi   (Italy)

^g Dipartimento di Patologia Sperimentale   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SHIGA TOXIN;

ARTICLE; BACTERIUM IDENTIFICATION; BIOASSAY; CHILD; CLINICAL ARTICLE; DIAGNOSTIC VALUE; EVALUATION; FECES ANALYSIS; FEMALE; FLOW CYTOMETRY; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN CELL; IMMUNODETECTION; INFANT; INTESTINE; INTESTINE INFECTION; LABORATORY TEST; MALE; NEUTROPHIL; PRIORITY JOURNAL; RISK FACTOR; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; VERO CELL; VERO CELL CYTOTOXICITY ASSAY;

ANIMALS; CERCOPITHECUS AETHIOPS; CHILD; CHILD, PRESCHOOL; DIGESTIVE SYSTEM; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FECES; FEMALE; FLOW CYTOMETRY; HEMOLYTIC-UREMIC SYNDROME; HUMANS; INFANT; MALE; NEUTROPHILS; SHIGA TOXINS; VERO CELLS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 32344449458     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.44.2.313-317.2006     Document Type: Article

References (26)

1. Athens, J. W. 1969. Granulocyte kinetics in health and disease, p. 135-155. In National Cancer Institute (ed.), Human tumor cell kinetics. National Cancer Institute, Bethesda, Md.
2. Bainton, D. F., J. L. Ullyot, and M. G. Farquhar. 1971. The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J. Exp. Med. 134:1907-1933.
3. Barbieri, L., P. Valbonesi, M. Brigotti, L. Montanaro, F. Stirpe, and S. Sperti. 1998. Shiga-like toxin I is a polynucleotide:adenosine glycosidase. Mol. Microbiol. 29:661-662.
4. Brigotti, M., R. Alfieri, P. Sestili, M. Bonelli, P. G. Petronini, A. Guidarelli, L. Barbieri, F. Stirpe, and S. Sperti. 2002. Damage to nuclear DNA induced by Shiga toxin 1 and by ricin in human endothelial cells. FASEB J. 16:365-372.
5. Caprioli, A., I. Luzzi, A. Gianviti, H. Russmann, and H. Karch. 1995. Phenogenotyping of verotoxin 2 (VT2)-producing Escherichia coli causing haemorrhagic colitis and haemolytic uraemic syndrome by direct analysis of patients' stools. J. Med. Microbiol. 43:348-353.
6. Caprioli, A., I. Luzzi, F. Rosmini, P. Pasquini, R. Cirrincione, A. Gianviti, M. C. Matteucci, and G. Rizzoni. 1992. Hemolytic-uremic syndrome and Vero cytotoxin-producing Escherichia coli infection in Italy. J. Infect. Dis. 166:154-158.
7. Caprioli, A., I. Luzzi, F. Rosmini, C. Resti, A. Edefonti, F. Perfumo, C. Farina, A. Goglio, A. Gianviti, and G. Rizzoni. 1994. Community-wide outbreak of hemolytic-uremic syndrome associated with non-O157 verocytotoxin-producing Escherichia coli. J. Infect. Dis. 169:208-211.
8. Endo, Y., K. Tsurugi, T. Yutsudo, Y. Takeda, T. Ogasawara, and K. Igarashi. 1988. Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur. J. Biochem. 171:45-50.
9. Garred, O., B. van Deurs, and K. Sandvig. 1995. Furin-induced cleavage and activation of Shiga toxin. J. Biol. Chem. 270:10817-10821.
10. Gavin, P. J., and R. B. Thomson. 2004. Diagnosis of enterohemorrhagic Escherichia coli infection by detection of Shiga toxins. Clin. Microbiol. Newsl. 26:49-54.
11. Gianviti, A., A. E. Tozzi, L. De Petris, A. Caprioli, L. Rava, A. Edefonti, G. Ardissino, G. Montini, G. Zacchello, A. Ferretti, C. Pecoraro, T. De Palo, A. Caringella, M. Gaido, R. Coppo, F. Perfumo, N. Miglietti, I. Ratsche, R. Penza, G. Capasso, S. Maringhini, S. Li Volti, C. Setzu, M. Pennesi, A. Bettinelli, L. Peratoner, I. Pela, E. Salvaggio, G. Lama, S. Maffei, and G. Rizzoni. 2003. Risk factors for poor renal prognosis in children with hemolytic uremic syndrome. Pediatr. Nephrol. 18:1229-1235.
12. Griffin, P. M., and R. V. Tauxe. 1991. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli and the associated hemolytic uremic syndrome. Epidemiol. Rev. 13:60-98.
13. Karmali, M. A., M. Petric, C. Lim, P. C. Fleming, G. S. Arbus, and H. Lior. 1985. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J. Infect. Dis. 151:775-782.
14. Liu, J., T. Akahoshi, T. Sasahana, H. Kitasato, R. Namai, T. Sasaki, M. Inoue, and H. Kondo. 1999. Inhibition of neutrophil apoptosis by verotoxin 2 derived from Escherichia coli O157:H7. Infect. Immun. 67:6203-6205.
15. Liu, J., Y. He, T. He, Z. Zhang, T. Akahoshi, H. Kondo, and S. Zhong. 2002. Prolongation of functional life-span of neutrophils by recombinant verotoxin 2. Chin. Med. J. 115:900-903.
16. Melton-Celsa, A. R., and A. O'Brien. 1998. Structure, biology, and relative toxicity of Shiga toxin family members for cells and animals, p. 121-128. In J. D. Kaper and A. D. O'Brien (ed.), Escherichia coli O157:H7 and other Shiga toxin-producing E. coli strains. American Society for Microbiology, Washington, D.C.
17. Nakao, H., and T. Takeda. 2000. Escherichia coli Shiga toxin. J. Nat. Toxins 9:299-313.
18. Nataro, J. P., and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11:142-201.
19. Paton, J. C., and A. W. Paton. 1998. Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clin. Microbiol. Rev. 11:450-479.
20. 2-induced DNA single strand breaks in cultured mammalian cells. DNA Repair (Amsterdam) 4:271-277.
21. Tazzari, P. L., F. Ricci, D. Carnicelli, A. Caprioli, A. E. Tozzi, G. Rizzoni, R. Conte, and M. Brigotti. 2004. Flow cytometry detection of Shiga toxins in the blood from children with hemolytic uremic syndrome. Cytom. B Clin. Cytom. 61:40-44.
22. te Loo, D. M., L. A. Monnens, T. J. van der Velden, M. A. Vermeer, F. Preyers, P. N. Demacker, L. P. van den Heuvel, and V. W. van Hinsbergh. 2000. Binding and transfer of verocytotoxin by polymorphonuclear leukocytes in hemolytic uremic syndrome. Blood 95:3396-3402.
23. te Loo, D. M., V. W. van Hinsbergh, L. P. van den Heuvel, and L. A. Monnens. 2001. Detection of verocytotoxin bound to circulating polymorphonuclear leukocytes of patients with hemolytic uremic syndrome. J. Am. Soc. Nephrol. 12:800-806.
24. Tozzi, A. E., A. Caprioli, F. Minelli, A. Gianviti, L. De Petris, A. Edefonti, G. Montini, A. Ferretti, T. De Palo, M. Gaido, and G. Rizzoni. 2003. Shiga toxin-producing Escherichia coli infections associated with hemolytic uremic syndrome, Italy, 1988-2000. Emerg. Infect. Dis. 9:106-108.
25. Trompeter, R. S., R. Schwartz, C. Chantler, M. J. Dillon, G. B. Haycock, R. Kay, and T. M. Barratt. 1983. Haemolytic-uremic syndrome: an analysis of prognostic features. Arch. Dis. Child. 58:101-115.
26. Walters, M. D., I. U. Matthei, R. Kay, M. J. Dillon, and T. M. Barratt. 1989. The polymorphonuclear leucocyte count in childhood haemolytic uraemic syndrome. Pediatr. Nephrol. 3:130-134.