End organ effects of high-dose human equivalent methylprednisolone in a spinal cord injury rat model

Spine

Volumn 31, Issue 3, 2006, Pages 257-261

  Kubeck, Justin P ^a   Merola, Andrew ^a   Mathur, Sameer ^a   Brkaric, Mario ^a   Majid, Kamran ^a   Shanti, Nael ^a   Caruso, Steve ^a   Yuan, Sontang ^a   Lowe, Thomas ^b   Dwyer, Anthony ^b   Haher, Thomas ^c   O'Brien, Michael ^d  

^a University Hospital of Brooklyn   (United States)

^b DENVER HEALTH MEDICAL CENTER   (United States)

^c LUTHERAN MEDICAL CENTER   (United States)

^d MIAMI CHILDREN'S HOSPITAL   (United States)

Author keywords

Methylprednisolone; Organ damage; Spinal cord injury

Indexed keywords

METHYLPREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EDEMA; HEART; HISTOLOGY; INTESTINE; KIDNEY; LAMINECTOMY; LIVER; LUNG; LUNG PARENCHYMA; LYMPHOCYTE DEPLETION; MICROSCOPY; NONHUMAN; PARAPLEGIA; PATHOLOGIST; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SPLEEN; STAINING; STATISTICAL SIGNIFICANCE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INTESTINES; LYMPHOPENIA; METHYLPREDNISOLONE; PULMONARY EOSINOPHILIA; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES;

EID: 32244448891     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000197151.95849.7f     Document Type: Article

References (17)

1. Carlson GD, Gorden CD, Nakazawa S, et al. Sustained spinal cord compression: Part II: Effect of methylprednisolone on regional blood flow and recovery of somatosensory evoked potentials. J Bone Joint Surg Am 2003;85-A:95-101.
2. Drscher WR, Weigert KP, Bunger MH, et al. Spinal blood flow in 24-hour megadose glucocorticoid treatment in awake pigs. J Neurosurg 2003;99(suppl 3):286-90.
3. Bracken MB, et al. Efficacy of methylprednisolone in acute spinal cord injury. JAMA 1984;251:45-52.
4. Bracken MB, et al. A randomized controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990;322:1405-11.
5. Bracken MB, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997;277:1597-604.
6. Vellman PW, Hawkes AP, Lammertse DP. Administration of corticosteroids for acute spinal cord injury: The current practice of trauma medical directors and emergence medical system physician advisors. Spine 2003;28:941-7.
7. Hulbert RJ, Moulton R. Why do you prescribe methylprednisolone for acute spinal cord injury? A Canadian perspective and a position statement. Can J Neurol Sci 2002;29:236-9.
8. Nesathuai S. Steroids and spinal cord injury: Revisiting NASCIS 2 and 3 trials. J Trauma 1998;45:1088-93.
9. Hulbert RJ. Methylprednisolone for acute spinal cord injury: An inappropriate standard of care. J Neurosurg 2000;93(suppl):1-7.
10. Means ED, Anderson DK, Waters TR, et al. Effects of methylprednisolone in compression trauma to the feline spinal cord. J Neurosurg 1981;55:200-8.
11. Freirich EJ, Gehan EA, Rall DP, et al. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 1966;50:219-44.
12. O'Brien MF, Lenke LG, Lu J, et al. Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury: An immunohistochemical investigation. Spine 1994;19:2321-48.
13. Allen AR. Remarks on the histopathological changes in the spinal cord due to impact: an experimental study. J Nerv Ment Dis 1914;41:141-7.
14. Fernandez E, Pallini R, Marchese E, et al. Experimental studies on spinal cord injuries in the last fifteen years. Neurol Res 1991;13:138-59.
15. Hall ED, Braughler JM, McCall JM. Antioxidant effects in brain and spinal cord injury. J Neurotrauma 192;9(suppl 1):S165-72.
16. Matsumoto T, Tamaki T, Kawakami M, et al. Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury. Spine 2001;26:426-30.
17. Merola A, O'Brien M, Castro A, et al. Histologic characterization of acute spinal cord injury treated with intravenous methylprednisolone. J Orthop Trauma 2002;16:155-61.