99mTc targeting of sst2-expressing tumors by tetraamine-octreotide: First results in CA20948 cells and rat models

Anticancer Research

Volumn 26, Issue 1 A, 2006, Pages 363-366

  Nikolopoulou, Anastasia ^a   Nock, Berthold A ^a   Maina, Theodosia ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

99mTc; Tyr3 octreotide; Somatostatin receptors; Tetraamine chelator; Tumor targeting

Indexed keywords

DEMOTIDE; DEMOTIDE TC 99M; PENTETATE INDIUM IN 111; PENTETREOTIDE; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR 2; TECHNETIUM 99M; TRACER; UNCLASSIFIED DRUG; 3 TYR OCTREOTIDE; 3-TYR-OCTREOTIDE; 99MTC DEMOTIDE; 99MTC-DEMOTIDE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; OCTREOTIDE; RADIOPHARMACEUTICAL AGENT; SOMATOSTATIN RECEPTOR; TECHNETIUM; TECHNETIUM COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG DISTRIBUTION; DRUG TARGETING; INTERNALIZATION; NEUROENDOCRINE TUMOR; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SCINTIGRAPHY; TISSUE DISTRIBUTION; VALIDATION PROCESS; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; CHEMISTRY; DRUG INTERACTION; ISOTOPE LABELING; LEWIS RAT; MALE; METABOLISM; PANCREAS TUMOR; SCINTISCANNING; WISTAR RAT;

ANIMALS; BINDING, COMPETITIVE; DRUG INTERACTIONS; ISOTOPE LABELING; MALE; OCTREOTIDE; ORGANOTECHNETIUM COMPOUNDS; PANCREATIC NEOPLASMS; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEW; RATS, WISTAR; RECEPTORS, SOMATOSTATIN; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 32144462668     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Hoyer D, Bell GI, Berelowitz M et al: Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 16: 86-88, 1995.
2. Reubi JC, Laissue J, Krenning E and Lamberts SW: Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications. J Steroid Biochem Mol Biol 43: 27-35, 1992.
3. Reubi JC, Waser B, Schaer JC and Laissue JA: Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur J Nucl Med 28: 836-846, 2001.
4. Bauer W, Briner U, Doepfner W et al: SMS 201-995: A potent and selective octapeptide analog of somatostatin with prolonged action. Life Sci 31: 1133-1140, 1982.
5. Breeman WAP, de Jong M, Kwekkeboom DJ et al: Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives. Eur J Nucl Med 28: 1421-1429, 2001.
6. 99mTc-labeled small peptides as diagnostic radiopharmaceuticals. Chem Rev 99: 2235-2268, 1999.
7. Vallabhajosula S, Moyer BR, Lister-James J et al: Preclinical evaluation of technetium-99m-labeled somatostatin receptor binding peptides. J Nucl Med 37: 1016-1022, 1996.
8. 111In-octreotide. J Nucl Med 41: 1114-1119, 2000.
9. 111In-labeled octreotide derivatives. Eur J Nucl Med 27: 1318-1325, 2000.
10. 1]octreotide, a new octreotide derivative with high affinity for somatostatin receptors. In: Technetium and Rhenium in Chemistry and Nuclear Medicine 4 (Nicolinin M, Badoli G, Mazzi U, eds.). Padova, SGEditoriali, pp. 395-400, 1995.
11. 3]octreotate analogue for the detection of somatostatin receptor-positive tumours: synthesis and preclinical results. Eur J Nucl Med 29: 742-753, 2002.
12. 99mTc-Demotate 1: first data in tumour patients - results of a pilot/phase I study. Eur J Nucl Med 30: 1211-1219, 2003.
13. 111In-labeled somatostatin analogs for tumour scintigraphy and radionuclide therapy. Cancer Res 58: 437-441, 1998.
14. Bernard BF, Krenning E, Breeman WAP et al: Use of the rat pancreatic CA20948 cell line for the comparison of the radiolabelled peptides for receptor-targeted scintigraphy and radionuclide therapy. Nucl Med Commun 21: 1079-1085, 2000.
15. Bläuenstein P, Pfeiffer G, Schubiger PA et al: Chemical and biological properties of a cationic Tc-tetraamine complex. Int J Appl Radiat Isot 36: 315-317, 1985.