New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity

Natural Product Research

Volumn 19, Issue 8, 2005, Pages 739-747

  Singh, Sheo B ^a   Kelly, Rosemarie ^a   Guan, Ziqiang ^a   Polishook, Jon D ^a   Dombrowski, Anne W ^a   Collado, Javier ^a   González, Antonio ^a   Pelaez, Fernando ^a   Register, Elizabeth ^a   Kelly, Theresa M ^a   Bonfiglio, Cynthia ^a   Williamson, Joanne M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antifungal activity; Azaphilone; Geranylgeranyltransferase I

Indexed keywords

4' HYDROXY 3' METHOXYMITORUBRIN; ANTIFUNGAL AGENT; GERANYLGERANYLTRANSFERASE I; GERANYLGERANYLTRANSFERASE I INHIBITOR; LUNATOIC ACID A; MITORUBRIN; PENICILLONE; PURPACTIN C; TRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CRYPTOCOCCUS NEOFORMANS; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ANTIFUNGAL AGENTS; BENZOPYRANS; ENZYME INHIBITORS; PIGMENTS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; FILOBASIDIELLA NEOFORMANS; SACCHAROMYCES CEREVISIAE;

EID: 32144446418     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/1478641042000334715     Document Type: Article

References (23)

1. Casey, P.J, Thissen, J.A, Moormaw, J.F. Proc. Natl. Acad. Sci. USA, 1991; 88: 8631
2. Shafer, W.R, Rine, J. Annu. Rev. Genet, 1992; 30: 209
3. Drgonova, J, Drgon, T, Tanaka, K, Kollar, R, Chen, G.-C, Ford, R.A, Chan, C.S.M, Takai, Y, Cabib, E. Science, 1996; 272: 277
4. Mazur, P, Baginsky, W. J. Biol. Chem, 1996; 271: 14604
5. Qadota, H, Python, C.P, Inoue, S.B, Arisawa, M, Anraku, Y, Zheng, Y, Watanabe, T, Levin, D.E, Ohya, Y. Science, 1996; 272: 279
6. Kondoh, O, Tachbana, Y, Ohya, Y, Arisawa, M, Watanabe, T. J. Bacteriol, 1997; 179: 7734
7. Mazur, P, Register, E, Bonfiglio, C.A, Yuan, X, Kurtz, M.B, Williamson, J.M, Kelly, R. Microbiol, 1999; 145: 1123
8. Smalera, I, Williamson, J.M, Baginsky, W, Leiting, B, Mazur, P. Biochim. Biophys. Acta, 2000; 1480: 132
9. Steglich, W, Klaar, M, Furtner, W. Phytochemistry, 1974; 13: 2874
10. Buchi, G, White, J.D, Wogan, G.W. J. Am. Chem. Soc, 1965; 87: 3484
11. Nozawa, K, Saito, R, Udagawa, S.-I, Nakajima, S, Kawai, K.-I. Phytochemistry, 1995; 39: 719
12. Tomoda, H, Nishida, H, Masuma, R, Cao, J, Okuda, S, Omura, S. J. Antibiotics, 1991; 44: 136
13. Nishida, H, Tomoda, H, Cao, J, Okuda, S, Omura, S. J. Antibiotics, 1991; 44: 144
14. Nukina, M, Marumo, S. Tetrahedron Lett, 1977; 18: 2603-2606
15. Marumo, S, Nukina, M, Kondo, S, Tomiyama, K. Agric. Biol. Chem, 1982; 46: 2399
16. Singh, S.B, Jayasuriya, H, Silverman, K.C, Bonfiglio, C.A, Williamson, J.M, Lingham, R.B. Bioorg. Med. Chem, 2000; 8: 571
17. Kelly, R, Card, D, Register, E, Mazur, P, Kelly, T, Tanaka, K.-I, Onishi, J, Williamson, J.M, Fan, H, Satoh, T, Kurtz, M. J. Bacteriol, 2000; 182: 704
18. Singh, S.B, Zink, D.L, Doss, G.A, Polishook, J.D, Ruby, C, Register, E, Kelly, T.M, Bonfiglio, C, Williamson, J.M, Kelly, R. Org. Lett, 2004; 6: 337
19. Nishimura, S, Matsunaga, S, Shibazaki, M, Suzuki, K, Harada, N, Naoki, H, Fusetani, N. J. Nat. Prod, 2002; 65: 1353
20. Bills, G.F, Polishook, J.D. Mycologia, 1994; 86: 187
21. Singh, S.B, Jayasuriya, H, Dewey, R, Polishook, J.D, Dombrowski, A.W, Zink, D.L, Guan, Z, Collado, J, Platas, G, Pelaez, F, Felock, P.J, Hazuda, D.J. J. Ind. Microbiol. Biotechnol, 2003; 30: 721
22. Jayasuriya, H, Silverman, K.C, Zink, D.L, Jenkins, R.G, Sánchez, M, Peláez, F., Vilella, D, Lingham, R.B, Singh, S.B. J. Nat. Prod, 1998; 61: 1568
23. Smith, C.J, Morin, N.R, Bills, G.F, Dombrowski, A.W, Salituro, G.M, Smith, S.K, Zhao, A, MacNeil, D.J. J. Org. Chem, 2002; 67: 5001