Reactions of OH-radicals with procarbazine. A pulse radiolysis and computer simulation study

Anticancer Research

Volumn 26, Issue 1 A, 2006, Pages 405-410

  Delipetar Grudl, A ^a   Solar, S ^a   Getoff, N ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

.OH radicals; Matulane; Natulan; Procarbazine; Pulse radiolysis; Ro 4 6467

Indexed keywords

CYTOSTATIC AGENT; HYDROXYL RADICAL; PROCARBAZINE;

ARTICLE; ATOM; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; COMPUTER SIMULATION; DRUG STRUCTURE; ELECTRON BEAM; ENTHALPY; PRIORITY JOURNAL; PROBABILITY; PULSE RADIOLYSIS; RADIATION ABSORPTION; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS; COMPUTER SIMULATION; HYDROXYL RADICAL; KINETICS; PROCARBAZINE; PULSE RADIOLYSIS;

EID: 32144438887     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Coleman M, Rafla S, Propert KJ and Glicksman A: Augmented therapy of extensive Hodgkins disease: radiation to known disease or prolongation of induction chemotherapy did not improve survival. Results of Cancer and Leukemia Group B Study. Int J Radiat Oncol Biol Phys 41: 639-645, 1998.
2. Gundersen S, Lote K and Wante K: A retrospective study of the value of chemotherapy as adjuvant therapy to surgery and radiotherapy in 3 and 4 gliomas. Eur J Cancer 34: 1565-1569, 1998.
3. Schelong G: Treatment of children and adolescents with Hodgkins disease. The experience of the German-Austrian paediatric study group. Bailliere's Clin Haematol 9: 619-634, 1996.
4. Reuss K, Engert A, Tesch H and Diehl V: Current clinical trails in Hodgkins disease. Ann Oncol 7(Suppl.4): 104-113, 1996.
5. Loshakov V, Kobiakov G and Lichinieer M: PVN-chemotherapy (procarbacine, nimustine, vincristine) in the treatment of patients with high grade glioma. Clin Neurol Neurosurg 99(Suppl.3): 3-7, 1997.
6. Delipetar A: Strahlenchemische und strahlenbiologische Untersuchungen an Sensibilisatoren. Thesis (in German), University of Vienna, pp. 135-169, 2000.
7. Delipetar-Grudl A and Getoff N: Procarbazine radiolysis and experiments in vitro. Anticancer Res 24: 1593-1596, 2004.
8. Getoff N: Pulse radiolysis: methodology and application (in German). Allgem Prakt Chem 20: 353-361, 1969.
9. Getoff N and Solar S: Radiation-induced formation of hematoporphyrin- transients in aqueous solution. A pulse radiolysis study. Int J Radiat Biol 67: 619-626, 1995.
10. Quint RM and Getoff N: Dose reduction and dose measurement for pulse radiolysis equipment, type "FEBETRON 708". Nucl Instr Meth Phys Res A 481: 81-85, 2002.
11. Dewar MJS, Zoebisch EG, Healy EF and Stewart JJP: Development and use of quantum mechanical molecular models, 76.AM1: a new general purpose quantum mechanical molecular model. J Am Chem Soc 707: 3902-3909, 1985.
12. Rauhut G, Alex A, Chandrasekhar J, Steinke T, Sauer W, Beck B, Hutter M, Gedeck P and Clark T: VAMP 6.1, Oxford Molecular Ltd., Oxford, GB, 1997.
13. Parusel ABJ, Schamschule R and Köhler G: Reduction and radical addition: a theoretical study on chlorobenzonitriles, Chroatia Chem. Acta 73: 359-366, 2000.
14. Buxton GV, Greenstock CL, Helman WP and Ross AB: Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. J Phys Chem Ref Data 17: 513-886, 1988.
15. Bachrach SM: In: Reviews in Computational Chemistry. Lipkowitz KB and Boyd DB (eds.). Indiana University-Purdue University at Indianapolis, IUPUI 5: 171-178, 1994.
16. Hayon E, Ibata NN and Simic M: Sites of attack of hydroxyl radicals on amides in aqueous solution. II. The effects of branching α to carbonyl and to nitrogen. J Am Chem Soc 93: 5388-5394, 1971.
17. Weinkam RJ and Shiba DA: Metabolic activation of procarbazine. Life Sci 22: 937-945, 1978.
18. Bruce GL and Boehlert JP: Separation and quantitation of possible degradation products of procarbazine hydrochloride in its dosage form. J Pharm Sci 67: 424-426, 1978.
19. Shiba DA and Weinkam RJ: Quantitative analysis of procarbazine, procarbazine metabolites and chemical degradation products with application to pharmacokinetic studies. J Chromatography 229: 397-407, 1982.
20. Erikson JM, Tweedie DJ, Ducore JM and Prough RA: Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L 1210 tumor cells. Cancer Res 49: 127-133, 1989.
21. Tweedie DJ, Fernandez D, Spearman ME, Feldhoff RC and Prough RA: Metabolism of azoxy derivatives of procarbazine by aldehyde dehydrogenase and xanthine oxidase. Drug Metabol Disposit 19: 793-803, 1991.
22. Buxton GV and Stuart CR: Radiation chemical studies of aqueous solutions of hydrazine up to 200°C. Water Chem Nucl React Syst 6: 198-199, 1992.