An adjunctive preventive treatment for heart disease and a set of diagnostic tests to detect it: Insulin-like growth factor-1 deficiency and cell membrane pathology are an inevitable cause of heart disease

Medical Hypotheses

Volumn 66, Issue 5, 2006, Pages 964-968

  Eli, Robert ^a   Fasciano, James A ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; HYPOCHOLESTEROLEMIC AGENT; LEVACECARNINE; MAGNESIUM; MECLOFENOXATE; SOMATOMEDIN C; ZINC;

AGING; ARTERY; ARTICLE; BLOOD PRESSURE MONITORING; BLOOD PRESSURE VARIABILITY; CELL MEMBRANE; CORONARY ARTERY DISEASE; DIAGNOSTIC TEST; DIARRHEA; HEART DISEASE; HEART INFARCTION PREVENTION; HEART RATE; HUMAN; ISCHEMIC HEART DISEASE; LUNG; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; SKELETAL MUSCLE; STOMACH PH; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE;

BLOOD PRESSURE; CELL MEMBRANE; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS; CORONARY DISEASE; EXERCISE TEST; HEART RATE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; MULTIPLE ORGAN FAILURE; PROGNOSIS;

EID: 32144436940     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.11.020     Document Type: Article

References (49)

1. Coronary Heart Disease The Department of Health-P&G: Health... Available at www.dh.gov.uk/Policy/AndGuidance/HealthandSocialCareTopics/ CoronaryHeart/Disease/fs/en.
2. P.R. Painter Allometric scaling of the maximum metabolic rate of mammals: oxygen transport from the lungs to the heart is a limiting step Theor Biol Med Model 2 2005 31
3. G. Sabatino, L.A. Ramenghi, and A. Verrotti Persistently low cardiac output predicts high mortality in newborns with cardiogenic shock Panminerva Med 40 1 1998 28 32
4. D.D. Sin, and S.F. Man Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality Proc Am Thorac Soc 2 1 2005 8 11
5. I. Serres, V. Gautier, and A. Varray Impaired skeletal muscle endurance related to physical inactivity and altered lung function in COPD patients Chest 113 4 1998 900 905
6. D.D. Sheriff, and R. Van Bibber Flow-generating capability of the isolated skeletal muscle pump AM J Physiol 274 5 Pt 2 1998 H1502 H1508
7. J.L. Izzo Jr., and B.E. Shykoff Arterial stiffness: clinical relevance, measurement, and treatment Rev Cardiovasc Med 2 1 2001 29 34 37-40
8. K. Kobayashi, R. Kouzuma, and M. Tsutsui Vasospastic Angina in a 16-year-old female Circ J 67 5 2003 467 469
9. G.F. Mitchell, H. Parise, and E.J. Benjamin Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study Hypertension 43 6 2004 1239 1245
10. L.D. Libera, and G. Vescovo Muscle wastage in chronic heart failure, between apoptosis, catabolism and altered anabolism: a chimaeric view of inflammation? Curr Opin Clin Nutr Metab Care 7 4 2004 435 441
11. J. Engdahl, A. Bang, and B.W. Karlson Long-term mortality among patients discharged alive after out-of- hospital cardiac arrest does not differ markedly compared with that of myocardial infarct patients without out-of-hospital cardiac arrest Eur J Emerg Med 8 4 2001 253 261
12. D.W. Kitzman, and W.D. Edwards Age-related changes in the anatomy of the normal human heart J Gerontol 45 2 1990 M33 M39
13. B.C. Schiller, Y.G. Casas, and C.A. Desouza Maximal aerobic capacity across age in healthy Hispanic and Caucasian women J Appl Physiol 91 3 2001 1048 1054
14. I. Zs-Nagy Pharmacological interventions against aging through the cell plasma membrane: a review of the experimental results obtained in animals and humans Ann N Y Acad Sci 959 2002 308 320 discussion 463-5
15. Congenital heart defects, How the heart works, NHLBI DC US Department of Health and Human Services Public Health Service. Available at www.nhlbi.nih.gov/health/dci/Diseases/chd/chd_heartworks.html.
16. A. Terman, H. Dalen, and J.W. Eaton Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover Ann N Y Acad Sci 1019 2004 70 77
17. V.G. Sharov, A. Goussev, and M. Lesch Abnormal mitochondrial function in myocardium of dogs with chronic heart failure J Mol Cell Cardiol 30 9 1998 1757 1762
18. S. Goldfischer, and J. Bernstein Lipofuscin (aging) pigment granules of the newborn human liver J Cell Biol 42 1 1969 253 261
19. M. Nakano, T. Mizuno, and H. Katoh Age-related accumulation of lipofuscin in myocardium of Japanese monkey (Macaca fuscata) Mech Ageing Dev 49 1 1989 41 48
20. N. Sitte, M. Huber, and T. Grune Proteasome inhibition lipofuscin/ceroid during postmitotic aging of fibroblasts FASEB J 14 11 2000 1490 1498
21. V.V. Tertov, V.V. Kaplun, and I.A. Mikhailova The content of lipoperoxidation products in normal and atherosclerotic human aorta Mol Cell Biochem 225 1- 2001 21 28
22. I. Zs-Nagy, K. Kitani, and M. Ohta Age-dependence of the lateral mobility of proteins in the plasma membrane of hepatocytes of C57BL/6 mice: FRAP studies on liver smears J Gerontol 44 4 1989 B83 B87
23. W.E. Sonntag, J.K. Brunso-Bechtold, and D.R. Riddle Age-related decreases in growth hormone and insulin-like growth factor (IGF)-1: Implications for Brain aging J Anti-aging Med 4 4 2001 311 329
24. G.A. Laughlin, E. Barrett-Connor, and M.H. Criqui The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study J Clin Endocrinol Metab 89 1 2004 114 120
25. S. Dore, S. Kar, and R. Quirion Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases Trends Neurosci 20 8 1997 326 331
26. C. Reboul, S. Tanguy, and J.M. Juan Cardiac remodeling and functional adaptations consecutive to altitude training in rats: implications for sea level aerobic performance J Appl Physiol 98 1 2005 83 92
27. P. Razeghi, S. Sharma, J. Ying, and Y.P. Li Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation Circulation 108 20 2003 2536 2541
28. M.J. Rennie, R.H. Edwards, and P.W. Emery Depressed protein synthesis is the dominant characteristic of muscle wasting and cachexia Clin Physiol 3 5 1983 387 398
29. J.R. Mynett, and P.H. Sugden Stimulation of cardiac protein synthesis by insulin-like growth factors Biochem J 282 Pt 1 1992 85 90
30. W. Cheng, K. Reiss, and P. Li Aging does not affect the activation of the myocyte insulin-like growth factor-1 autocrine system after infarction and ventricular failure in Fischer 344 rats Circ Res 78 4 1996 536 546
31. Hagen TM, Moreau R, Suh JH, et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-l-carnitine and/or lipoic acid.
32. P. Gregorevic, D.R. Plant, and K.S. Leeding Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration Am J Pathol 161 6 2002 2263 2272
33. B.L. Wolfe, C.B. Rich, and H.D. Goud Insulin-like growth factor-I regulates transcription of the elastin gene J Biol Chem 268 17 1993 12418 12426
34. J.M. Gonzalez, A.M. Briones, B. Starcher, M.V. Conde, B. Somoza, and C. Daly Influence of elastin on rat small artery mechanical properties Exp Physiol 90 4 2005 463 468
35. A. Avolio, D. Jones, and M. Tafazzoli-Shadpour Quantification of alterations in structure and function of elastin in the arterial media Hypertension 32 1 1998 170 175
36. L. Di Marzio, S. Moretti, and S. D'Alo Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation Clin Immunol 92 1 1999 103 110
37. P.E. Spoerri, P. Glees, and E. El Ghazzawi Accumulation of lipofuscin in the myocardium of senile guinea pigs: dissolution and removal of lipofuscin following dimethylaminoethyl p-chlorphenoxyacetate administration. An electron microscopic study Mech Ageing Dev 3 5-6 1974 311 312
38. W.G. Wood, C. Gorka, and H.J. Armbrecht Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice Life Sci 39 22 1986 2089 2095
39. R.E. Smith, and D.J. Hoijer Metabolism and cellular function in cold acclimation Physiol Rev 42 1962 60 142
40. D. Sharma, A.K. Maurya, and R. Singh Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine Neurobiol Aging 14 4 1993 319 330
41. P.L. Wood, and A. Peloquin Increases in choline levels in rat brain elicited by meclofenoxate Neuropharmacology 21 4 1982 349 354
42. S. Sueda, N. Ochi, and H. Kawada Frequency of provoked coronary vasospasm in patients undergoing coronary arteriography with spasm provocation test of acetylcholine Am J Cardiol 83 8 1999 1186 1190
43. B. Marchant, R. Stevenson, and S. Vaishnav Influence of the autonomic nervous system on circadian patterns of myocardial ischemia: comparison of stable angina with the postinfarction period Brit Heart J 71 1994 329 333
44. J. Figueras, and R.M. Lidon Circadian rhythm of angina in patients with unstable angina: relationship with extent of coronary disease, coronary reserve and ECG changes during pain Eur Heart J 15 6 1994 753 760
45. I. Dorup, A. Flyvbjerg, and M.E. Everts Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies Br J Nutr 66 3 1991 505 521
46. R. Sega, G. Corrao, and M. Bombelli Blood pressure variability and organ damage in a general population: results from the PAMELA study (Pressioni Arteriose Monitorate E Loro Associazioni) Hypertension 39 2 Pt 2 2002 710 714
47. U.E. Heidland, and B.E. Strauer Left ventricular muscle mass and elevated heart rates are associated with coronary plaque disruption Circulation 104 13 2001 1477 1482
48. J. Watanabe, M. Thamilarasan, and E.H. Blackstone Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as predictors of mortality: the case of stress echocardiography Circulation 104 16 2001 1911 1916
49. Y.J. Cheng, C.A. Macera, and T.S. Church Heart rate reserve as a predictor of cardiovascular and all-cause mortality in men Med Sci Sports Exerc 34 12 2002 1873 1878