Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1735-1739

  Barrett, David G ^a,b   Catalano, John G ^a   Deaton, David N ^a   Hassell, Anne M ^a   Long, Stacey T ^a   Miller, Aaron B ^a   Miller, Larry R ^a   Ray, John A ^a   Samano, Vicente ^a   Shewchuk, Lisa M ^a   Wells Knecht, Kevin J ^a,c   Willard Jr , Derril H ^a   Wright, Lois L ^a  

^a GLAXOSMITHKLINE   (United States)

^b LILLY DEUTSCHLAND GMBH   (Germany)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cathepsin K; Inhibitor; Ketoamide; Osteoporosis; Synthesis

Indexed keywords

AMINOKETONE; CATHEPSIN K INHIBITOR; SUCCINIMIDE DERIVATIVE; AMIDE; CATHEPSIN; CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; KETONE; PYRROLIDINE; PYRROLIDINE DERIVATIVE; SERINE PROTEINASE INHIBITOR;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; HUMAN; IC 50; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

AMIDES; BINDING SITES; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KETONES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044468137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.101     Document Type: Article

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