Fatal anaphylactoid reaction after primary exposure to aprotinin

Interactive Cardiovascular and Thoracic Surgery

Volumn 5, Issue 1, 2006, Pages 25-26

  López Almodóvar, Luis Fernando ^a   Lima, Pedro ^a   Cañas, Alfonso ^a   Calleja, Manuel ^a  

^a HOSPITAL VIRGEN DE LA SALUD   (Spain)

Author keywords

Resuscitation; Surgery complications; Surgery emergency

Indexed keywords

ADRENALIN; APROTININ; CALCIUM CHLORIDE; CIMETIDINE; DIPHENHYDRAMINE; METHOXAMINE; METHYLPREDNISOLONE; NORADRENALIN;

AGED; ANAMNESIS; ANAPHYLAXIS; ARTICLE; BLEEDING; BLOOD PRESSURE MONITORING; CARDIOPULMONARY BYPASS; CASE REPORT; DRUG EXPOSURE; DRUG HYPERSENSITIVITY; FATALITY; FEMALE; HEART ATRIUM FIBRILLATION; HUMAN; INFLAMMATION; MITRAL VALVE REPLACEMENT; PEROPERATIVE COMPLICATION; PRIORITY JOURNAL; RESUSCITATION; STERNOTOMY; URTICARIA;

EID: 32044458836     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1510/icvts.2005.118885     Document Type: Article

References (7)

1. Levy, JH. Pharmacologic preservation of the hemostatic system during cardiac surgery. Ann Thorac Surg 2001;72:S1814-S1820.
2. Peters DC, Noble S. Aprotinin: an update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery. Drugs 1999;57:233-260.
3. Levy JH, Pifarre R, Schaff HV, Horrow JC, Albus R, Spiess B, Rosengart TK, Murry J, Clark RE, Smith P. A multicenter, placebo-controlled, double blind trial of aprotinin to reduce blood loss and the requirement of donor blood transfusion in patients undergoing repeat coronary artery bypass grafting. Circulation 1995;92:2236-2244.
4. Beierlein W, Scheule AM, Dietrich W, Ziemer G. Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions. Ann Thorac Surg 2005;79:741-748.
5. Cohen DM, Norberto J, Cartabuke R, Ryu G. Severe anaphylactic reaction after primary exposure to aprotinin. Ann Thorac Surg 1999; 67:837-838.
6. Beierlein W, Scheule AM, Ziemer G. Anaphylactic aprotinin reaction (Letter). Ann Thorac Surg 2000;69:1298.
7. Scheule AM, Beierlein W, Arnold S, Eckstein FS, Albes JM, Ziemer G. The significance of preformed Aprotinin-specific antibodies in cardiosurgical patients. Anesth Analg 2000;90:262-266.