Adaptive designs for dose-finding based on efficacy-toxicity response

Journal of Statistical Planning and Inference

Volumn 136, Issue 6, 2006, Pages 1800-1823

  Dragalin, Vladimir ^a   Fedorov, Valerii ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Adaptive design; Cox bivariate binary model; Dose finding; Gumbel logistic regression model; Information matrix; Optimal experimental design; Optimal safe dose; Phase I II clinical trials

Indexed keywords

EID: 32044450843     PISSN: 03783758     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jspi.2005.08.005     Document Type: Article

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