Novel vitamin D3 antipsoriatic antedrugs: 16-En-22-oxa-1α, 25-(OH)2D3 analogs

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 1838-1850

  Shimizu, Kazuki ^a   Kawase, Akira ^a   Haneishi, Tsuyoshi ^a   Kato, Yasuharu ^a   Kobayashi, Takamitsu ^a   Sekiguchi, Nobuo ^a   Yamamoto, Tessai ^a   Ishigai, Masaki ^a   Tokuda, Kazuo ^a   Matsushita, Tomochika ^a   Shimaoka, Shin ^a   Morikawa, Kazumi ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

16 En 22 oxa 1 ,25 dihydroxyvitamin D3 analogs; Antedrug; Low calcemic activity; Psoriasis

Indexed keywords

1ALPHA,3BETA DIHYDROXY 20 (3 HYDROXY 3 METHYLBUTYLOXY) 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; 1ALPHA,3BETA DIHYDROXY 20 (4 HYDROXY 4 METHYL 2 PENTENYLOXY) 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; 1ALPHA,3BETA DIHYDROXY 20 (4 HYDROXY 4 METHYL 2 PENTYLYLOXY) 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; 1ALPHA,3BETA DIHYDROXY 20 (4 HYDROXY 4 METHYLPENTYL OXY) 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; 1ALPHA,3BETA DIHYDROXY 20 (4 HYDROXY 4 METHYLPENTYLOXY) 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; 1ALPHA,3BETA DIHYDROXY 20 HYDROXY 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; 1ALPHA,3BETA DIHYDROXY 20[(4 HYDROXY 4 METHYL 2 PENTENYLOXY)] 9,10 SECOPREGNA 5,7,10(19),16 TETRAENE; ANTIPSORIASIS AGENT; COLECALCIFEROL; UNCLASSIFIED DRUG; DRUG DERIVATIVE; VITAMIN D;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; DRUG BINDING; DRUG LIVER LEVEL; DRUG STRUCTURE; DRUG USE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; DRUG SCREENING; EPIDERMIS; KERATINOCYTE; LIVER MICROSOME; PSORIASIS;

ANIMALIA;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; EPIDERMIS; HUMANS; KERATINOCYTES; MALE; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PSORIASIS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D;

EID: 32044435347     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.034     Document Type: Article

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