Oral ranitidine and duration of gastric pH >4.0 in infants with persisting reflux symptoms

Acta Paediatrica, International Journal of Paediatrics

Volumn 95, Issue 2, 2006, Pages 176-181

  Salvatore, Silvia ^a   Hauser, Bruno ^b   Salvatoni, Alessandro ^a   Vandenplas, Yvan ^b,c  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Gastric acid; Gastro oesophageal reflux; Infants; Oesophagitis; pH study; Ranitidine

Indexed keywords

ALGINIC ACID; GAVISCON; RANITIDINE;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ESOPHAGITIS; ESOPHAGUS BIOPSY; FEMALE; GASTROESOPHAGEAL REFLUX; HISTOLOGY; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; PH MEASUREMENT; PRIORITY JOURNAL; REGRESSION ANALYSIS; STOMACH ACID; STOMACH ACID SECRETION; STOMACH PH; SYMPTOMATOLOGY;

ADMINISTRATION, ORAL; ANTI-ULCER AGENTS; BIOPSY; ESOPHAGITIS; ESOPHAGUS; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; HUMANS; HYDROGEN-ION CONCENTRATION; INFANT; RANITIDINE; SEVERITY OF ILLNESS INDEX;

EID: 31944439229     PISSN: 08035253     EISSN: 15023869     Source Type: Journal    
DOI: 10.1080/08035250500327609     Document Type: Article

References (29)

1. Hyams JS, Ricci A, Leichtner AM. Clinical and laboratory correlates of esophagitis in young children. J Pediatr Gastroenterol Nutr 1988;7:52-6.
2. Black DD, Haggitt RC, Orenstein SR. Esophagitis in infants. Morphometric histological diagnosis and correlation with measures of gastroesophageal reflux. Gastroenterology 1990;98:1408-14.
3. Vandenplas Y. Reflux esophagitis in infants and children. A report from the Working Group of the European Society of Pediatric Gastroenterology and Nutrition on Gastro-oesophageal Reflux Disease. J Pediatr Gastroenterol Nutr 1994;18:413-22.
4. Newell SJ, Kelly EJ. Ranitidine in infants. Arch Dis Childhood 1993;69:544.
5. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children. J Pediatr Gastroenterol Nutr 2001;32(Suppl 2):S1-31.
6. Kulkarni PN, Batra YK, Wig J. Effects of different combination of H2 receptor antagonist with gastrokinetic drugs on gastric fluid pH and volume in children - a comparative study. Int J Clin Pharmacol Ther 1997;35:561-4.
7. Parkman HP, Urbain JL, Knight LC, Brown KL, Trate DM, Miller MA, et al. Effect of gastric acid suppressants on human gastric motility. Gut 1998;42:243-50.
8. Jones R, Bytzer P. Acid suppression in the management of gastro-oesophageal reflux disease - an appraisal of treatment options in primary care. Aliment Pharmacol Ther 2001;15:765-72.
9. Berstad A. A modified hemoglobin substrate method for the estimation of pepsin in gastric juice. Scand J Gastroenterol 1970;5:343-8.
10. Cucchiara S, Staiano A, Gobio Casali L, Boccieri A, Paone FM. Value of the 24 hours intraoesophageal pH monitoring in children. Gut 1990;31:129-33.
11. Heine RG, Cameron DJ, Chow CW, Hill DJ, Catto-Smith AG, et al. Esophagitis in distressed infants: poor diagnostic agreement between esophageal pH monitoring and histopathologic findings. J Pediatr 2002;140:14-9.
12. Vandenplas Y, Badriul H, Verghote M, Hauser B, Kaufman L. Oesophageal pH monitoring and reflux oesophagitis in irritable infants. Eur J Pediatr 2004;163:300-4.
13. Kelly DA. Do H2 receptor antagonists have a therapeutic role in childhood? J Pediatr Gastroenterol Nutr 1994;19:270-6.
14. Washington N, Spensley PJ, Smith CA, Parker M, Bush D, Jackson SJ, et al. Dual pH probe monitoring versus single pH probe monitoring in infants on milk feeds: the impact on diagnosis. Arch Dis Child 1999;81:309-12.
15. Orenstein SR, Blumer JL, Faessel HM, McGuire JA, Fung K, Li BU, et al. Ranitidine, 75 mg, over-the-counter dose: phamacokinetic and pharmacodynamic effects in children with symptoms of gastroesophageal reflux. Aliment Pharmacol Ther 2002;16:899-907.
16. Blumer JL, Rothstein FC, Kaplan BS, Yamashita TS, Eshelman FN, Myers CM, et al. Pharmacokinetic determination of ranitidine pharmacodynamics in pediatric ulcer disease. J Pediatr 1985;107:301-6.
17. Cucchiara S, Minella R, lervolino C, Franco MT, Campanozzi A, Franceschi M, et al. Omeprazole and high dose ranitidine in the treatment of refractory reflux esophagitis. Arch Dis Child 1993;69:655-9.
18. Cucchiara S, Companozzi A, Greco C, Franco MT, Emiliano M, Alfieri E, et al. Predictive value of esophageal manometry and gastroesophageal pH monitoring for responsiveness of reflux disease to medical therapy in children. Am J Gastroenterol 1996;91:680-5.
19. Mallet E, Mouterde O, Dubois F, Flipo JN, Moore N. Use of ranitidine in young infants with gastro-oesophageal reflux. Eur J Clin Pharmacol 1989;36:641-2.
20. Kuusela A-L. Long term gastric pH monitoring for determining optimal dose of ranitidine for critically ill preterm and term neonates. Arch Dis Child Fetal Neonatal Ed 1998;78:F151-3.
21. Sutphen JL, Dillard VL, Pipan ME. Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux. Pediatrics 1986;78:55-7.
22. Washington N, Spensley PJ, Smith CA, Parker M, Bush D, Jackson SJ, et al. Dual pH probe monitoring versus single pH probe monitoring in infants on milk feeds: the impact on diagnosis. Arch Dis Child 1999;81:309-12.
23. Mitchell DJ, McClure BG, Tubman TR. Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Arch Dis Child 2001;84:273-6.
24. Vandenplas Y, Sacre L, Loeb H. Effects of formula feeding on gastric acidity time and oesophageal pH monitoring data. Eur J Pediatr 1988;148:152-4.
25. 2-receptor antagonists. Aliment Pharmacol Ther 1990;4(Suppl 1):15-27.
26. 2-receptor antagonists. An overview. Scand J Gastroenterol 1992;27(Suppl 193):14-9.
27. Hyman PE, Garvey TQ, Abrams CE. Tolerance to intravenous ranitidine. J Pediatr 1987;110:794-6.
28. Fackler WK, Ours TM, Vaezi MF, Ricther JE. Long-term effect of H2RA therapy on nocturnal gastric acid breakthrough. Gastroenterology 2002;122:625-32.
29. Buts JP, Barudi C, Otte JB. Double-blind controlled study on the efficacy of sodium alginate (Gaviscon) in reducing gastroesophageal reflux assessed by 24 h continuous pH monitoring in infants and children. Eur J Pediatr 1987;146:156-8.