Kehokorins A-C, novel cytotoxic dibenzofurans isolated from the myxomycete Trichia favoginea var. persimilis

Tetrahedron Letters

Volumn 47, Issue 10, 2006, Pages 1505-1508

  Kaniwa, Kouken ^a   Ohtsuki, Takashi ^a   Yamamoto, Yukinori ^a   Ishibashi, Masami ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Cytotoxicity; Dibenzofuran; Fruit body; Myxomycete; Trichia favoginea var. persimilis

Indexed keywords

DIBENZOFURAN DERIVATIVE; KEHOKORIN A; KEHOKORIN B; KEHOKORIN C; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; MYXOMYCETES; NONHUMAN; SPECTROSCOPY;

MYXOGASTRIA; TRICHIA FAVOGINEA;

EID: 31944436512     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.01.012     Document Type: Article

References (15)

1. W. Steglich Pure Appl. Chem. 61 1989 281 288
2. M. Ishibashi Atta-ur-Rahman Studies in Natural Products Chemistry Vol. 29 2003 Elsevier Amsterdam 223 262
3. M. Ishibashi Med. Chem. 1 2005 575 590 and references cited therein
4. The fruit bodies of Trichia favoginea var. persimilis were collected at Tosayamada-shi in Kochi Prefecture, Japan, in January 2004. A voucher specimen (#25634) is maintained by Y.Y. (Ohtsu-ko, Kochi).
5. 3/MeOH, 1:1) to afford kehokorin B (2, 10.0 mg) and kehokorin C (3, 1.2 mg).
6. + 513.1761, found m/z 513.1759.
7. 5″,6″ = 6.5 Hz, indicating that H-2″ was equatorial and H-3″, H-4″, and H-5″ were axial.
8. 13C NMR data.
9. K. Bock, I. Lundt, and C. Pedersen Tetrahedron Lett. 13 1973 1037 1040
10. +) 366.1103, found m/z 366.1096.
11. +) 336.0998, found m/z 366.0984.
12. Y. Takaya, H. Kikuchi, Y. Terui, J. Komiya, Y. Maeda, A. Ito, and Y. Oshima Tetrahedron Lett. 42 2001 61 63
13. V. Calí, C. Spatafora, and C. Tringali Atta-ur-Rahman Studies in Natural Products Chemistry Vol. 29 2003 Elsevier Amsterdam 263 307
14. N. Radulovic, D.N. Quang, T. Hashimoto, M. Nukada, and Y. Asakawa Phytochemistry 66 2005 1052 1059
15. J.-K. Liu, L. Hu, Z.-J. Dong, and Q. Hu Chem. Biodiversity 1 2004 601 605 and references cited therein