Silicosis and lung cancer: A fifty-year perspective

Acta Biomedica de l'Ateneo Parmense

Volumn 76, Issue SUPPL. 2, 2005, Pages 30-37

  Saffiotti, Umberto ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Adhesion molecules; DNA binding and DNA damage; Neoplastic transformation of alveolar type II cells in culture; Neuroendocrine cells; Silica induced carcinogenesis; Transforming growth factor ; Tumor necrosis factor

Indexed keywords

ADRENOMEDULLIN; ALPHA AMIDATING ENZYME; CALCITONIN GENE RELATED PEPTIDE; CELL ADHESION MOLECULE; CYTOKINE; DNA; GROWTH FACTOR; HYDROXYL RADICAL; PEPTIDE; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

BRONCHUS MUCOSA; CANCER MODEL; CELL CULTURE; CONFERENCE PAPER; CONNECTIVE TISSUE; DNA BINDING; DNA DAMAGE; DNA METHYLATION; DNA TRANSCRIPTION; EPIGENETICS; FIBROBLAST; HUMAN; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; LUNG CARCINOGENESIS; LUNG FIBROSIS; MACROPHAGE; MALIGNANT TRANSFORMATION; NEUROSECRETORY CELL; NONHUMAN; PATHOGENESIS; PROMOTER REGION; SILICOSIS; TRANSCRIPTION INITIATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CYTOKINES; GROWTH SUBSTANCES; HUMANS; LUNG NEOPLASMS; RATS; SILICOSIS; TIME FACTORS;

EID: 31944433904     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (53)

1. Pernis B, Saffiotti U, Tommasini Degna A. Il comportamento delle mastcellule polmonari nel corso della silicosi del ratto. Med Lavoro 1958; 49: 405-18.
2. Saffiotti U. The histogenesis of experimental silicosis. I. Methods for the histological evaluation of experimentally induced dust lesions. Med Lavoro 1960; 51: 10-7.
3. Saffiotti U, Tommasini Degna A, Mayer L. The histogenesis of experimental silicosis. II. Cellular and tissue reactions in the histogenesis of pulmonary lesions. Med Lavoro 1960; 51: 518-52.
4. Saffiotti U. The histogenesis of experimental silicosis. III. Early cellular reactions and the role of necrosis. Med Lavoro 1962; 53: 5-18.
5. Saffiotti U, Ferrario I. La necrosi dei macrofagi, fenomeno condizionante la patogenesi immunitaria della silicosi. Atti XXIII Congresso Naz. di Medicina del Lavoro. (INAIL, Milano, Italy, 1959): 130-4.
6. Saffiotti U, Tommasini Degna A. Studi sulla silicosi sperimentale da materiali refrattari. I. Attività silicotigena di polveri di mattoni refrattari usati nei forni Martin. Med Lavoro 1958; 49: 347-67.
7. Saffiotti U. The pathology induced by silica in relation to fibrogenesis and carcinogenesis. In: Goldsmith DF, Winn DM, Shy CM (Eds). Silica, Silicosis and Cancer (Praeger, New York, 1986): 287-307.
8. Merewether ERA. Annual Report of the Chief Inspector of Factories for the year 1947. (HMSO, London, 1949): 15-7.
9. Doll R. Mortality from lung cancer in asbestos workers. Brit J Ind Med 1955; 12: 81-6.
10. Saffiotti U, Cefis F, Kolb LH. A method for the experimental induction of bronchogenic carcinoma. Cancer Res 1968; 28: 104-24.
11. Montesano R, Saffiotti U, Ferrero A, Kaufman DG. Synergistic effects of benzo[α]pyrene and diethylnitrosamine on respiratory carcinogenesis in hamsters. J Natl Cancer Inst 1974; 53: 1395-7.
12. Saffiotti U, Montesano R, Sellakumar AR, Borg SA. Studies of experimental lung cancer: Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors. Cancer 1967; 20: 857-64.
13. Saffiotti U, Baker CG. Program planning in inhalation carcinogenesis: National Cancer Institute plans. In Hanna MGJr, Nettesheim P, Gilbert JR (Eds). Inhalation Carcinogenesis, Atomic Energy Commission Symposium Series, No. 18 (CONF-700501). (U.S. Atomic Energy Commission, Division of Technical Information Extension, Oak Ridge, TN, 1970): 467-81.
14. Wagner MMF, Wagner JC. Lymphoma in the Wistar rat after intrapleural inoculation of silica. J Nat Cancer Inst 1972; 49: 81-91.
15. Holland LM, Gonzales M, Wilson JS, Tillery MI. Pulmonary effects of shale dust in experimental animals. In Wagner WL, Rom WN, Merchant JA (Eds). Health Issues Related to Metal and Nonmetallic Mining. (Boston, Butterworth 1983): 485-96.
16. Goldsmith DF, Winn DM, Shy CM (Eds). Silica, Silicosis and Cancer. (New York, Praeger, 1986).
17. Groth DH, Stettler LE, Platek SF, Lal JB, Burg JR. Lung tumors in rats treated with quartz by intratracheal in-stillation. In Goldsmith DF, Winn DM, Shy CM (Eds). Silica, Silicosis and Cancer (New York, Praeger, 1986): 243-53.
18. Dagle GE, Wehner AP, Clark ML, Buschbom RL. Chronic inhalation exposure of rats to quartz. In Goldsmith DF, Winn DM, Shy CM (Eds). Silica, Silicosis and Cancer (New York, Praeger, 1986): 255-66.
19. Holland LM, Wilson JS, Tillery MI, Smith DM. Lung cancer in rats exposed to fibrogenic dusts. In Goldsmith DF, Winn DM, Shy CM (Eds). Silica, Silicosis and Cancer (New York, Praeger, 1986): 267-279
20. International Agency for Research on Cancer. Silica. In IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol 42 (Lyon, 1987): 39-143.
21. International Agency for Research on Cancer. Silica. In IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol 68 (Lyon, 1997): 41-242.
22. Saffiotti U. Attività cancerogena della silice e possibile ruolo patogenetico della reazione cellulare fibrogena. Med Lavoro 1985; 76: 351-7.
23. Niemeier RW, Mulligan LT, Rowland J. Cocarcinogenicity of foundry silica sand in hamsters. In Goldsmith DF, Winn DM, Shy CM (Eds). Silica, Silicosis and Cancer (New York, Praeger, 1986): 215-27.
24. Saffiotti U, Williams AO, Daniel LN, Kaighn ME, Mao Y, Shi X. Carcinogenesis by crystalline silica: animal, cellular, and molecular studies. In: Castranova V, Vallyathan V, Wallace WE (Eds) Silica and silica-induced diseases (Boca Raton, FL, CRC Press, 1996): 345-81.
25. Saffiotti U. Lung cancer induction by crystalline silica. In: D'Amato R, Slaga TJ, Farland WH, Henry C (Eds). Relevance of Animal Studies to the Evaluation of Human Cancer Risk. (New York, Wiley-Liss, 1992): 51-69.
26. Also as: Progr Clin Biol Res 1992; 374: 51-69.
27. Simone NL, Bonner RF, Gillespie JW, Emmert-Buck MR, Liotta LA. Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet 1998; 14: 272-6.
28. Hesterberg TW, Barrett JC. Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. Cancer Res 1984; 44: 2170-80.
29. Saffiotti U, Ahmed N. Neoplastic transformation by quartz in the BALB/3T3/A31-1-1 cell line and the effects of associated minerals. Teratogen Carcinog Mutagen 1995; 15: 339-56.
30. Williams AO, Knapton AD, Ifon ET, Saffiotti U. Transforming growth factor beta expression and transformation of rat lung epithelial cells by crystalline silica (quartz). Internal J Cancer 1996; 65: 639-49.
31. Mao Y, Knapton AD, Saffiotti U. Neoplastic transformation induced by quartz at different doses in the fetal rat alveolar epithelial cell line, FRLE. Sixth International Meeting on the Toxicology of Natural and Man-made Fibrous and Non-fibrous Particles, (Lake Placid, NY, Sept. 15-18, 1995); Abstract 3: 59.
32. Daniel LN, Mao Y, Williams AO, Saffiotti U. Direct interaction of crystalline silica and DNA - a proposed model for silica carcinogenesis. Scand J-Work Environ Health, 1995; 21 (Suppl. 2): 22-6
33. Thomassen DG, Saffiotti U, Kaighn ME. Clonal proliferation of rat tracheal epithelial cells in serum free medium and their response to hormones, growth factors and carcinogens. Carcinogenesis 1986; 7: 2033-9.
34. Saffiotti U. Respiratory tract carcinogenesis by mineral fibres and dusts: models and mechanisms. Monaldi Arch Chest Dis 1998; 53: 160-7.
35. Fubini B, Bolis V, Giamello E, Pugliese L, Violante M. The formation of oxygen reactive radicals at the surface of the crushed quartz dusts as a possible cause of silica pathogenicity. In Mossman BT, Begin RO (Eds). Effects of mineral dusts on cells. (Berlin, Springer-Verlag, 1989): 205-14.
36. Daniel LN, Mao Y, Saffiotti U. Oxidative DNA damage by crystalline silica. Free Radic Biol Med, 1993; 14: 463-72.
37. Mao Y, Daniel LN, Whittaker N, Saffiotti U. DNA binding to crystalline silica characterized by Fourier-transform infrared spectroscopy. Environ Health Perspect 1994; 102 (Suppl. 10): 165-71.
38. Shi X, Mao Y, Daniel LN, Saffiotti U, Dalai NS, Vallyathan V. Generation of reactive oxygen species by quartz particles and its implication for cellular damage. Appl Occup Environ Hyg 1995; 10: 1138-44.
39. Daniel LN, Mao Y, Wang T-CL, et al. DNA strand breakage, thymine glycol production and hydroxyl radical generation induced by different samples of crystalline silica in vitro. Environ Res 1995; 71: 60-73.
40. Fubini B, Zanetti G, Altilia S, Tiozzo R, Lison D, Saffiotti U. Relationship between surface properties and cellular response to crystalline silica: Studies with heat-treated cristobalite. Chem Res Toxicol 1999; 12: 737-45.
41. Driscoll KE, Lindenschmidt RC, Maurer JK, Higgins JM, Ridder G. Pulmonary response to silica or titanium dioxide: Inflammatory cells, alveolar macrophage-derived cytokines and histopathology. Am J Respir Cell Mol Biol 1990; 2: 381-90.
42. Piguet PF, Collart MA, Grau GE, Sappino A-P, Vassalli P. Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis. Nature 1990; 344: 245-7.
43. Mao Y, Saffiotti U, Daniel LN, Shi X, Ahmed N. Tumor necrosis factor-α (TNF-α) inhibits neoplastic transformation (Tf) induced by quartz in BALB/3T3/A31-1-1 cells. Proc Amer Assoc Cancer Res 1995; 36: 177.
44. Saffiotti U. From human and experimental silica carcinogenesis to molecular mechanisms, transcription factors and signaling pathways. Am J Indust Med 2005 (in press).
45. Chen F, Shi X. NF-kappaB, a pivotal transcription factor in silica-induced diseases. Mol Cell Biochem 2002; 234-235(1-2): 169-76.
46. Hubbard AK, Timblin CR, Shukla A, Rincon M, Mossman BT. Activation of NF-κB-dependent gene expression by silica in lungs of luciferase reporter mice. Am J Physiol Lung Cell Mol Physiol 2002; 282: L968-L975.
47. Williams AO, Flanders KC, Saffiotti U. Immunohistochemical localization of transforming growth factor-β1 in rats with experimental silicosis and alveolar type II epithelial hyperplasia, and lung cancer. Am J Pathol 1993; 142: 1831-40.
48. Williams AO, Knapton AD, Saffiotti U. Growth factors and gene expression in silica-induced fibrogenesis and carcinogenesis. Appl Occup Environ Hyg 1995; 10: 1089-98.
49. Williams AO, Saffiotti U. Transforming growth factor β1, ras and p53 in silica-induced fibrogenesis and carcinogenesis. Scand J Work Environ Health 1995; 21 (Suppl. 2): 30-4.
50. Wang L, Bowman L, Lu Y, et al. Essential role of p53 in silica-induced apoptosis. Am J Physiol Lung Cell Mol Physiol 2005; 288(3): L488-L496.
51. Elizegi E, Pino I, Vicent S, Blanco D, Saffiotti U, Montuenga LM. Hyperplasia of alveolar neuroendocrine cells in rat lung carcinogenesis by silica with selective expression of proadrenomedullin-derived peptides and amidating enzymes. Lab Invest 2001; 81: 1627-38.
52. Blanco D, Vicent S, Elizegi E, et al. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Lab Invest 2004; 84: 999-1012.
53. Blanco D, Vicent S, Estibalitz E, et al. Genetic and epigenetic alterations in Ras family members and adhesion molecules in a multistep rat lung carcinogenesis model. Proc Am Assoc Cancer Res 2005; 46: 5736.