Effects of PNS on stability of atherosclerotic plaque and initial investigation for its mechanism

Chinese Journal of Natural Medicines

Volumn 4, Issue 1, 2006, Pages 62-65

  Yuan, Zhi Bing ^a   Li, Xiao Hui ^a   Li, Shu Hui ^a   Fan, Ji Shan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Matrix metalloproteinase 2; Stability of plaques; Total saponin of Panax notoginseng; Vascular endothelial growth factor

Indexed keywords

GELATINASE A; PANAX NOTOGINSENG EXTRACT; SAPONIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL WALL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; RABBIT; TUNICA MEDIA;

EID: 31844453946     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. (Zhou ZB), (Guo Y). Chinese source. (Foreign Med Sci (Cerebrovasc Dis)), 2004,12 (2):137-140.
2. Kullo IJ, Edwards WD, Schwartz RS. Vulnerable plaque: pathobiology and clinical implications. Ann Intern Med, 1998, 129 (12): 1050-1060.
3. (Liu LS), (Yang YZ). Chinese source. (Chin J Arterioscler), 2000, 8 (2):182-184.
4. (Jia Y), (Li XH). Chinese source. Acad Med Mil Tert), 2005, 27 (10) :972-974.
5. Tangirala RK, Rubin W. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. Lipid Res, 1995, 36(11):2320-2328.
6. (Sun Q), (Gao ZY), (Lu W). Chinese source. PCNA (Chin J Stereol Imaging Anal), 1998, 3 (4): 228-229.
7. Galis ZS, Sukhova KG, Lark MW, et al. Increased expression of matrix metalloprotease and matrix degrading activity in voulnerable regions of human atherosclerotic plaques. Clin Invest, 1994, 94 (6): 2493-2503.
8. (Li YL), (Meng XP), (Qu L). Chinese source. (Chin J Emery Med), 2003 12 (4): 231-233.
9. Chen YX, Nakashima Y, Tanaka K, et al. Immunohistochemical expression of vascular endothelial growth factor/vascular permeability factor in atherosclerotic intimas of human coronary arteries. Arterioscler Thromb Vasc Biol, 1999, 19 (1): 131-139.
10. Zhang Y, Cliff WJ, Schoefl GI, et al. Immunohistochemical study of intimal microvessels in coronary atherosclerosis. Pathol, 1993, 143 (1): 164-172.
11. Jeziorska M, Woolley DE. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. Pathol, 1999, 188 (2): 189-196.
12. Moulton KS, Heller E, Kinerding MA, et al. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation, 1999, 99 (13): 1726-1732.