Grey variants of the live vaccine strain of Francisella tularensis lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice

Vaccine

Volumn 24, Issue 7, 2006, Pages 989-996

  Hartley, Gill ^a   Taylor, Rosa ^a   Prior, Jo ^a   Newstead, Sarah ^a   Hitchen, Paul G ^b   Morris, Howard R ^b,c   Dell, Anne ^b   Titball, Richard W ^a,d  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c M SCAN Mass Spectrometry Research and Training Centre   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

LVS; O antigen; Tularemia; Vaccine

Indexed keywords

LIPOPOLYSACCHARIDE; LIVE VACCINE; O ANTIGEN;

ANIMAL CELL; ANTIGENIC VARIATION; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIUM CULTURE; BACTERIUM ISOLATION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; FRANCISELLA TULARENSIS; IMMUNE RESPONSE; MACROPHAGE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; BACTERIAL VACCINES; CELL LINE; FLOW CYTOMETRY; FRANCISELLA TULARENSIS; MACROPHAGES; MICE; MICE, INBRED BALB C; O ANTIGENS;

EID: 31844435574     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.08.075     Document Type: Article

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