Interferon-γ- and interleukin-4-producing T cells in Down's syndrome

Neuroscience Letters

Volumn 395, Issue 1, 2006, Pages 67-70

  Franciotta, Diego ^a   Verri, Annapia ^a   Zardini, Elisabetta ^a   Andreoni, Laura ^a   De Amici, Mara ^a   Moratti, Remigio ^a   Nespoli, Luigi ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

Apolipoprotein E genotype; Celiac disease; Down's syndrome; Interferon ; Interleukin 4; Mental retardation

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; INTERLEUKIN 4; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELIAC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN SYNDROME; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; KARYOTYPE; MALE; MENTAL DEFICIENCY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRISOMY 21;

ADULT; DOWN SYNDROME; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; MALE; MENTAL RETARDATION; MIDDLE AGED; T-LYMPHOCYTES;

EID: 31744440030     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.10.048     Document Type: Article

References (17)

1. I. Blasko, G. Ransmayr, R. Veerhuis, P. Eikelenboom, and B. Grubeck-Loebenstein Does IFNγ play a role in neurodegeneration? J. Neuroimmunol. 116 2001 1 4
2. G.R. Burgio, A.G. Ugazio, L. Nespoli, A.F. Marcioni, A.M. Bottelli, and F. Pasquali Derangements of immunoglobulin levels, phytohemagglutinin responsiveness and T and B cell markers in Down's syndrome at different ages Eur. J. Immunol. 5 1975 600 603
3. R.J. Cattel, C.G. Hamon, J.A. Corbett, J. Lejeune, and J.A. Blair Neopterin:biopterin ratios in Down's syndrome J. Neurol. Neurosurg. Psychiatry 52 1989 1015 1016
4. M.M. Corsi, W. Ponti, A. Venditti, F. Ferrara, C. Baldo, M. Chiappelli, and F. Licastro Proapoptotic activated T-cells in the blood of children with Down's syndrome: relationship with dietary antigen and intestinal alterations Int. J. Tissue React. 25 2003 117 125
5. A. Cossarizza, C. Ortolani, E. Forti, G. Montagnani, R. Paganelli, M. Zannotti, M. Marini, D. Monti, and C. Franceschi Age-related expansion of functionally inefficient cells with markers of natural killer activity in Down's syndrome Blood 77 1991 1263 1270
6. R. Del Bo, G.P. Comi, N. Bresolin, E. Castelli, E. Conti, A. Degiuli, C.D. Ausenda, and G. Scarlato The apolipoprotein E ε4 allele causes a faster decline of cognitive performances in Down's syndrome subjects J. Neurol. Sci. 145 1997 87 91
7. D. Franciotta, E. Zardini, R. Bergamaschi, L. Andreoni, and V. Cosi Interferon γ and interleukin 4 producing cells in peripheral blood of multiple sclerosis patients undergoing immunomodulatory treatment J. Neurol. Neurosurg. Psychiatry 74 2003 123 126
8. J.E. Hixon, and D.T. Vernier Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI J. Lipid Res. 31 1990 545 548
9. S.P. James Prototypic disorders of gastrointestinal mucosal immune function: Celiac disease and Crohn's disease J. Allergy Clin. Immun. 115 2005 25 30
10. T.R. Mosmann, and S. Sad The expanding universe of T-cell subsets: Th1, Th2 and more Immunol. Today 17 1996 138 146
11. M. Murphy, D.S. Friend, L. Pike-Nobile, and L.B. Epstein Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21) J. Immunol. 149 1992 2506 2512
12. E. Park, J. Alberti, P. Mehta, A. Dalton, E. Sersen, and G. Schuller-Levis Partial impairment of immune functions in peripheral blood leukocytes from aged men with Down's syndrome Clin. Immunol. 95 2000 62 69
13. Y. Refaeli, L. Van Parijs, S.I. Alexander, and A.K. Abbas Interferon gamma is required for activation-induced death of T lymphocytes J. Exp. Med. 196 2002 999 1005
14. + T cells secreting Th1 and Th2 cytokines Immunity 2 1995 271 279
15. I. Scotese, L. Gaetaniello, G. Matarese, M. Lecora, L. Racioppi, and C. Pignata T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome Pediatr. Res. 44 1998 252 258
16. F.X. Weilbach, and K.V. Toyka Does Down's syndrome protect against multiple sclerosis? Eur. Neurol. 47 2002 52 55
17. K.H. Weisgraber, A.D. Roses, and W.J. Strittmatter The role of apolipoprotein E in the nervous system Curr. Opin. Lipidol. 5 1994 110 116