Transcriptomic and histopathology changes in rat lung after intratracheal instillation of polymers

Inhalation Toxicology

Volumn 18, Issue 4, 2006, Pages 227-245

  Carthew, Philip ^a   Fletcher, Samantha ^a   White, Andrew ^a   Harries, Helen ^b   Weber, Klaus ^c  

^a UNILEVER RESEARCH   (United Kingdom)

^b Microscience Ltd   (United Kingdom)

^c RCC Ltd   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID DERIVATIVE; OSTEOPONTIN; POLYMER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CHRONIC INFLAMMATION; CONTROLLED STUDY; DOSE RESPONSE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GRANULOMA; HISTOPATHOLOGY; IMMUNE RESPONSE; LUNG GRANULOMA; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTICULATE MATTER; PNEUMONIA; PRIORITY JOURNAL; RAT; TIME SERIES ANALYSIS; TISSUE INJURY; TRANSCRIPTOMICS; UNINDEXED SEQUENCE; UPREGULATION;

ACRYLATES; ADMINISTRATION, INHALATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LUNG; MACROPHAGES, ALVEOLAR; MALE; MALEATES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYETHYLENES; RATS; RATS, WISTAR; TOXICITY TESTS, SUBCHRONIC; TRANSCRIPTOME;

ANIMALIA;

EID: 31744436845     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370500444304     Document Type: Article

References (10)

1. Carthew, P., Griffiths, H., Keech, S., and Hartop, P. 2002. Safety assessment forhairspray resins: Risk assessment based on rodent inhalation studies. Inhal. Toxicol. 14:401-416.
2. Farr, S., and Dunn, R. T. 1999. Concise review: Gene expression applied to toxicology. Toxicol. Sci. 50:1-9.
3. Kodavanti, U. P., Jackson, M. C., Ledbetter, A. D., Richards, J. R., Gardner, S. Y., Watkinson, W. P., Campen, M. J., and Costa, D. L. 1999. Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension. J. Toxicol. Environ. Health A 57:543-563.
4. Lobenhofer, E. K., Bushel, P. R., Afshari, C. A., and Hamadeh, H. K. 2001. Progress in the application of DNA microarrays. Environ Health Perspect. 109:881-891.
5. Mauderly, J. L. 1996. Lung overload: The dilemma and opportunity for resolution. In Particle overload in the rat lung and lung cancer. Implications for risk assessment, eds. J. L. Mauderly and R. J. McCunney, pp. 1-28. London: Taylor & Francis.
6. Oberdorster, G. 2000. Determinants of the pathogenicity of manmade vitreous fibers (MMVF). Int. Arch. Occup. Environ. Health 73(suppl):S60-S68.
7. Pelizzari, C. A., Khodarev, N. N., Gupta, N., Calvin, D. P., and Weichselbaum, R. R. 2000. Quantitative analysis of DNA array autoradiographs. Nucleic Acid Res. 28(22):4577-4581.
8. Schena, M., Shalon, D., David, R. W., and Brown, P. O. 1995. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467-470.
9. Waters, M. D., Olden, K., and Tennant, R. W. 2003. Toxicogenomic approach for assessing toxicant-related disease. Mutat. Res. 544:415-424.
10. Yang, Y., Sharma, R., Zimniak, P., and Awasthi, Y. C. 2002. Role of alpha class glutathione S-transferases as antioxidant enzymes in rodent tissues. Toxicol. Appl. Pharmacol. 15, 182(2):105-115.