Lactate in the intensive care unit: Pyromaniac, sentinel or fireman?

Critical Care

Volumn 9, Issue 6, 2005, Pages 622-623

  Leverve, Xavier M ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; LACTIC ACID; ADENOSINE TRIPHOSPHATE; GLUCOSE 6 PHOSPHATE;

ACID BASE BALANCE; ACIDOSIS; ADAPTATION; CELL METABOLISM; ENERGY BALANCE; ENERGY METABOLISM; HUMAN; HYPERLACTATEMIA; INTENSIVE CARE; LACTATE BLOOD LEVEL; MAMMAL; METABOLIC DISORDER; METABOLISM; NOTE; PATIENT MONITORING; PRIORITY JOURNAL; PROGNOSIS; TURNOVER TIME; ENERGY EXPENDITURE; HOMEOSTASIS; OXIDATION REDUCTION POTENTIAL; PH;

ACID-BASE IMBALANCE; BIOLOGICAL MARKERS; ENERGY METABOLISM; HUMANS; INTENSIVE CARE; LACTIC ACID; OXYGEN CONSUMPTION;

EID: 31744434995     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc3935     Document Type: Note

References (12)

1. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL: Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1991, 99:956-962.
2. Leverve XM, Mustafa I: Lactate: A key metabolite in the intercellular metabolic interplay. Crit Care 2002, 6:284-285.
3. Valenza F, Aletti G, Fossali T, Chevallard G, Sacconi F, Irace M, Gattinoni L: Lactate as a marker of energy failure in critically ill patients: hypothesis. Crit Care 2005, 9:588-593.
4. Leverve XM: Energy metabolism in critically ill patients: lactate is a major oxidizable substrate. Curr Opin Clin Nutr Metab Care 1999, 2:165-169.
5. Sutton JR, Jones NL, Toews CJ: Effect of PH on muscle glycolysis during exercise. Clin Sci (Lond) 1981, 61:331-338.
6. Ehrsam RE, Heigenhauser GJ, Jones NL: Effect of respiratory acidosis on metabolism in exercise. J Appl Physiol 1982, 53: 63-69.
7. Bulbulian R, Girandola RN, Wiswell RA: The effect of NH4Cl induced chronic metabolic acidosis on work capacity in man. Eur J Appl Physiol Occup Physiol 1983, 51:17-24.
8. Kowalchuk JM, Heigenhauser GJ, Jones NL: Effect of pH on metabolic and cardiorespiratory responses during progressive exercise. J Appl Physiol 1984, 57:1558-1563.
9. Barclay JK, Graham TE, Wolfe BR, Van Dijk J, Wilson BA: Effect of acidosis on skeletal muscle metabolism with and without propranolol. Can J Physiol Pharmacol 1990, 68:870-876.
10. Bharma S, Milsom WK: Acidosis and metabolic rate in golden mantled ground squirrels (Spermophilus lateralis). Respir Physiol 1993, 94:337-351.
11. Hotchkiss RS, Karl IE: Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. J Am Med Assoc 1992, 267:1503-1510.
12. Levy B, Gibot S, Franck P, Cravoisy A, Bollaert PE: Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 2005, 365:871-875.