An increase in MPC-1- and MPC-1-CD45+ immature myeloma cells in the progressive states of bone marrow plasmacytosis: The revised phenotypic classification of monoclonal marrow plasmacytosis (MOMP-2005)

International Journal of Hematology

Volumn 83, Issue 1, 2006, Pages 39-43

  Otsuyama, Ken Ichiro ^a   Asaoku, Hideki ^b   Kawano, Michio M ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

Author keywords

CD45; Immature myeloma cells; MPC 1; Multiple myeloma; Progression

Indexed keywords

ALPHA5 INTEGRIN; ANTIBODY; CD38 ANTIBODY; CD45 ANTIGEN; CELL PROTEIN; PROTEIN MPC 1; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELL COUNT; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE CLASSIFICATION; HUMAN; HUMAN CELL; MONOCLONAL IMMUNOGLOBULINEMIA; MONOCLONAL MARROW PLASMACYTOSIS; MULTIPLE MYELOMA; MYELOMA CELL; PHENOTYPE; PLASMA CELL; PLASMACYTOSIS; STAINING;

ANTIGENS, CD; ANTIGENS, CD45; BONE MARROW CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; MALE; MULTIPLE MYELOMA; NEOPLASM PROTEINS; PLASMA CELLS;

EID: 31644440539     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.05112     Document Type: Article

References (16)

1. Terstappen LW, Johnson S, Segers-Nolten IM, Loken MR. Identification and characterization of plasma cells in normal human bone marrow by high-resolution flow cytometry. Blood. 1990;76:1739-1747.
2. Harada H, Kawano MM, Huang N, et al. Phenotypic difference of normal plasma cells from mature myeloma cells. Blood. 1993;81:2658-2663.
3. Kawano MM, Huang N, Harada H, et al. Identification of immature and mature myeloma cells in the bone marrow of human myelomas. Blood. 1993;82:564-570.
4. - immature myeloma cells correlated well with poor response to treatment in multiple myeloma. Br J Haematol. 1995;91:860-864.
5. + subpopulations that can proliferate in response to IL-6 in human myelomas. Br J Haematol. 1999;105:131-140.
6. Robillard N, Pellat-Deceunynck C, Bataille R. Phenotypic characterization of the human myeloma cell growth fraction. Blood. 2005;105:4845-4848.
7. Joshua D, Petersen A, Brown R, Pope B, Snowdon L, Gibson J. The labeling index of primitive plasma cells determines the clinical behaviour of patients with myelomatosis. Br J Haematol. 1996;94:76-81.
8. Mahmoud MS, Ishikawa H, Fujii R, Kawano MM. Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6. Blood. 1998;92:3887-3897.
9. Ishikawa H, Tsuyama N, Kawano MM. Interleukin-6-induced proliferation of human myeloma cells associated with CD45 molecules. Int J Hematol. 2003;78:95-105.
10. Huang N, Kawano MM, Harada H, et al. Heterogeneous expression of a novel MPC-1 antigen on myeloma cells: possible involvement of MPC-1 antigen in the adhesion of mature myeloma cells to bone marrow stromal cells. Blood. 1993;82:3721-3729.
11. Asosingh K, De Raeve H, Menu E, et al. Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity. Blood. 2004;103:3131-3137.
12. Pellat-Deceunynck C, Bataille R. Normal and malignant human plasma cells: proliferation, differentiation, and expansions in relation to CD45 expression. Blood Cells Mol Dis. 2004;32:293-301.
13. Kawano MM, Mihara K, Tsujimoto T, Huang N, Kuramoto A. A new phenotypic classification of bone marrow plasmacytosis. Int J Hematol. 1995;61:179-188.
14. Tarte K, Zhan F, De Vos J, Klein B, Shaughnessy J. Gene expression profiling of plasma cells and plasmablasts: toward a betler understanding of the late stages of B-cell differentiation. Blood. 2003;102:592-600.
15. Zhan F, Hardin J, Kordsmeier B, et al. Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. Blood. 2002;99:1745-1757.
16. Tarte K, De Vos J, Thykjaer T, et al. Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts. Blood. 2002;100:1113-1122.