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Volumn 68, Issue 4, 2005, Pages 1630-1642

Characterization of glycosaminoglycans in tubular epithelial cells: Calcium oxalate and oxalate ions effects

Author keywords

Calcium oxalate; Glycosaminoglycan; LLC PK1; MDCK; Potassium oxalate; Proteoglycan

Indexed keywords

CALCIUM ION; CALCIUM OXALATE; CARBOXYLIC ACID; CHONDROITIN SULFATE; FLUORESCENT DYE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HYDROXYAPATITE; OXALIC ACID; THAPSIGARGIN;

EID: 31644432094     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00577.x     Document Type: Article
Times cited : (26)

References (47)
  • 1
    • 0028072835 scopus 로고
    • Madin-Darby canine kidney cells are injured by exposure to oxalate and to calcium oxalate crystals
    • HACKETT RP, SHEVOCK PN, KHAN SR: Madin-Darby canine kidney cells are injured by exposure to oxalate and to calcium oxalate crystals. Urol Res 22:197-203, 1994
    • (1994) Urol Res , vol.22 , pp. 197-203
    • Hackett, R.P.1    Shevock, P.N.2    Khan, S.R.3
  • 2
    • 0032705806 scopus 로고    scopus 로고
    • Crystal-cell interaction and apoptosis in oxalte-associated injury of renal epithelial cell
    • KHAN SR, BYER KJ, THAMILSELVAN S, et al: Crystal-cell interaction and apoptosis in oxalte-associated injury of renal epithelial cell. J Am Soc Nephrol 10(Suppl 14):S457-S463, 1999
    • (1999) J Am Soc Nephrol , vol.10 , Issue.14 SUPPL.
    • Khan, S.R.1    Byer, K.J.2    Thamilselvan, S.3
  • 3
    • 0029958413 scopus 로고    scopus 로고
    • Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cell
    • KOUL H, KENNINGTON L, HONEYMAN T, et al: Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cell. Kidney Int 50:1525-1530, 1996
    • (1996) Kidney Int , vol.50 , pp. 1525-1530
    • Koul, H.1    Kennington, L.2    Honeyman, T.3
  • 4
    • 0029148170 scopus 로고
    • Calcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells
    • HAMMES MS, LIESKE JC, PAWAR S, et al: Calcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells. Kidney Int 48:501-509, 1995
    • (1995) Kidney Int , vol.48 , pp. 501-509
    • Hammes, M.S.1    Lieske, J.C.2    Pawar, S.3
  • 5
    • 0015918874 scopus 로고
    • Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro
    • ROBERTSON WG, PEACOCK M, NORDIN BEC: Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro. Clin Chim Acta 43:31-37, 1973
    • (1973) Clin Chim Acta , vol.43 , pp. 31-37
    • Robertson, W.G.1    Peacock, M.2    Nordin, B.E.C.3
  • 6
    • 0022477523 scopus 로고
    • Crystal inhibition: The effects of polyanions on calcium oxalate growth
    • FELLSTROM B, DANIELSON BG, LJUNGHALL S, WIKSTROM B: Crystal inhibition: the effects of polyanions on calcium oxalate growth. Clin Chim Acta 158:229-235, 1986
    • (1986) Clin Chim Acta , vol.158 , pp. 229-235
    • Fellstrom, B.1    Danielson, B.G.2    Ljunghall, S.3    Wikstrom, B.4
  • 7
    • 0024563811 scopus 로고
    • Surface interaction between glycosaminoglycans and calcium oxalate
    • ANGELL AH, RESNICK MI: Surface interaction between glycosaminoglycans and calcium oxalate. J Urol 141:1255-1258, 1989
    • (1989) J Urol , vol.141 , pp. 1255-1258
    • Angell, A.H.1    Resnick, M.I.2
  • 8
    • 0024818173 scopus 로고
    • Urinary excretion of glycosaminoglycans in normal and stone forming subjects
    • MICHELACCI YM, GLASHAN RQ, SCHOR N: Urinary excretion of glycosaminoglycans in normal and stone forming subjects. Kidney Int 36:1022-1028, 1989
    • (1989) Kidney Int , vol.36 , pp. 1022-1028
    • Michelacci, Y.M.1    Glashan, R.Q.2    Schor, N.3
  • 9
    • 0028997540 scopus 로고
    • Adhesion of calcium oxalate crystals to Madin-Darby canine kidney cells and some effects of glycosaminoglycans or cell injuries
    • EBISUNO S, KOHJIMOTO Y, TAMURA M, OHKAWA T: Adhesion of calcium oxalate crystals to Madin-Darby canine kidney cells and some effects of glycosaminoglycans or cell injuries. Eur Urol 28:68-73, 1995
    • (1995) Eur Urol , vol.28 , pp. 68-73
    • Ebisuno, S.1    Kohjimoto, Y.2    Tamura, M.3    Ohkawa, T.4
  • 10
    • 0030021498 scopus 로고    scopus 로고
    • Crystal-cell interaction inhibition by polysaccharides
    • VERKOELEN CF, ROMIJN JC, CAO LC, et al: Crystal-cell interaction inhibition by polysaccharides. J Urol 155:749-752, 1996
    • (1996) J Urol , vol.155 , pp. 749-752
    • Verkoelen, C.F.1    Romijn, J.C.2    Cao, L.C.3
  • 11
    • 0028898236 scopus 로고
    • Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions
    • LIESKE TC, LEONARD R, TOBACK FG: Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions. Am J Physiol 268:F604-F612, 1993
    • (1993) Am J Physiol , vol.268
    • Lieske, T.C.1    Leonard, R.2    Toback, F.G.3
  • 14
    • 0034078095 scopus 로고    scopus 로고
    • Urinary excretion of glycosaminoglycans and albumin in experimental diabetes mellitus
    • CADAVAL RAM, KOHLMAN O, MICHELACCI YM: Urinary excretion of glycosaminoglycans and albumin in experimental diabetes mellitus. Glycobiology 10:185-192, 2000
    • (2000) Glycobiology , vol.10 , pp. 185-192
    • Cadaval, R.A.M.1    Kohlman, O.2    Michelacci, Y.M.3
  • 15
    • 0035220974 scopus 로고    scopus 로고
    • Renal and urinary glycosaminoglycans in a experimental model of chronic renal failure in rats
    • MICHELACCI YM, CADAVAL RAM, ROVIGATTI RM, KOHLMAN O: Renal and urinary glycosaminoglycans in a experimental model of chronic renal failure in rats. Exp Nephrol 9:40-48, 2001
    • (2001) Exp Nephrol , vol.9 , pp. 40-48
    • Michelacci, Y.M.1    Cadaval, R.A.M.2    Rovigatti, R.M.3    Kohlman, O.4
  • 16
    • 0026664257 scopus 로고
    • Possible role for chondroitin sulfate in urolithiasis: In vivo studies in an experimental model
    • MICHELACCI YM, BOIM MA, BERGAMASCHI CT, et al: Possible role for chondroitin sulfate in urolithiasis: In vivo studies in an experimental model. Clin Chim Acta 208:1-8, 1992
    • (1992) Clin Chim Acta , vol.208 , pp. 1-8
    • Michelacci, Y.M.1    Boim, M.A.2    Bergamaschi, C.T.3
  • 17
    • 0032815533 scopus 로고    scopus 로고
    • Recent insights into the structure and function of heparan sulfate proteoglycans in the human glomerular basement membrane
    • GROFFEN AJA, VEERKAMP JH, MONNENS LAH, VAN DEN HEUVEL LPW: Recent insights into the structure and function of heparan sulfate proteoglycans in the human glomerular basement membrane. Nephrol Dial Transplant 14:2119-2129, 1999
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 2119-2129
    • Groffen, A.J.A.1    Veerkamp, J.H.2    Monnens, L.A.H.3    Van Den Heuvel, L.P.W.4
  • 18
    • 0027406534 scopus 로고
    • Basement membrane proteoglycans in glomerular morphogenesis: Chondroitin sulfate proteoglycan is temporally and spatially restricted during development
    • MCCARTHY KJ, BYNUM K, ST. JOHN PL, et al: Basement membrane proteoglycans in glomerular morphogenesis: Chondroitin sulfate proteoglycan is temporally and spatially restricted during development. J Histochem Cytochem 41:401-414, 1993
    • (1993) J Histochem Cytochem , vol.41 , pp. 401-414
    • McCarthy, K.J.1    Bynum, K.2    St. John, P.L.3
  • 19
    • 0033797511 scopus 로고    scopus 로고
    • Small proteoglycans of normal adult human kidney distinct expression patterns of decorin, biglycan, fibromodulin and lumican
    • SCHAEFER L, GRONE HJ, RASLIK I, et al: Small proteoglycans of normal adult human kidney distinct expression patterns of decorin, biglycan, fibromodulin and lumican. Kidney Int 58:1557-1568, 2000
    • (2000) Kidney Int , vol.58 , pp. 1557-1568
    • Schaefer, L.1    Grone, H.J.2    Raslik, I.3
  • 20
    • 0346505363 scopus 로고    scopus 로고
    • Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease
    • KURODA M, SASAMURA H, KOBAYASHI E, et al: Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease. Clin Nephrol 61:7-16, 2004
    • (2004) Clin Nephrol , vol.61 , pp. 7-16
    • Kuroda, M.1    Sasamura, H.2    Kobayashi, E.3
  • 21
    • 0029932980 scopus 로고    scopus 로고
    • Proteoglycans and glycosaminoglycans synthesized in vitro by mesangial cells from normal and diabetic rats
    • HADAD SJ, MICHELACCI YM, SCHOR N: Proteoglycans and glycosaminoglycans synthesized in vitro by mesangial cells from normal and diabetic rats. Biochim Biophys Acta 1290:18-28, 1996
    • (1996) Biochim Biophys Acta , vol.1290 , pp. 18-28
    • Hadad, S.J.1    Michelacci, Y.M.2    Schor, N.3
  • 22
    • 0036447276 scopus 로고    scopus 로고
    • Heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG) and bikunin are up-regulated during calcium oxalate nephrolithiasis in rat kidney
    • EGUCHI Y, INOUE M. IIDA S, et al: Heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG) and bikunin are up-regulated during calcium oxalate nephrolithiasis in rat kidney. Kurume Med J 49:90-107, 2002
    • (2002) Kurume Med J , vol.49 , pp. 90-107
    • Eguchi, Y.1    Inoue, M.2    Iida, S.3
  • 23
    • 0036954601 scopus 로고    scopus 로고
    • Role of Heparan sulfate proteoglycan (syndecan-1) on the renal epithelial cells during calcium oxalate monohydrate crystal attachment
    • CHIKAMA S, IIDA S, INOUE M, et al: Role of Heparan sulfate proteoglycan (syndecan-1) on the renal epithelial cells during calcium oxalate monohydrate crystal attachment. Kurume Med J 49:201-210, 2002
    • (2002) Kurume Med J , vol.49 , pp. 201-210
    • Chikama, S.1    Iida, S.2    Inoue, M.3
  • 24
    • 0037385226 scopus 로고    scopus 로고
    • An improved methodology to produce Flavobacterium heparinum chondroitinases, important instruments for diagnosis of disease
    • AGUIAR JA, LIMA CR, BERTO AG, MICHELACCI YM: An improved methodology to produce Flavobacterium heparinum chondroitinases, important instruments for diagnosis of disease. Biotechnol Appl Biochem 37 (Pt 2):115-127, 2003
    • (2003) Biotechnol Appl Biochem , vol.37 , Issue.2 PART , pp. 115-127
    • Aguiar, J.A.1    Lima, C.R.2    Berto, A.G.3    Michelacci, Y.M.4
  • 25
    • 0025153110 scopus 로고
    • Purification and substrate specificity of heparitinase I and heparitinase II from Flavobacterium heparinum. Analyses of the heparin and heparan sulfate degradation products by 13C NMR spectroscopy
    • NADER HB, PORCIONATTO MA, TERSARIOL ILS, et al: Purification and substrate specificity of heparitinase I and heparitinase II from Flavobacterium heparinum. Analyses of the heparin and heparan sulfate degradation products by 13C NMR spectroscopy. J Biol Chem 265:16807-16813, 1990
    • (1990) J Biol Chem , vol.265 , pp. 16807-16813
    • Nader, H.B.1    Porcionatto, M.A.2    Tersariol, I.L.S.3
  • 26
    • 0000747456 scopus 로고
    • Preparation of extracellular matrices produced by cultured bovine corneal endothelial cells and PF-HR-9 endodermal cells: Their use in cell culture, in methods for preparation of media, supplements and substrata to serum-free animal cell culture
    • edited byBarnes DN, Sirbasku DA, Sato GH, New York, Alan R. Liss
    • GOSPODAROWICZ D: Preparation of extracellular matrices produced by cultured bovine corneal endothelial cells and PF-HR-9 endodermal cells: their use in cell culture, in methods for preparation of media, supplements and substrata to serum-free animal cell culture, in Methods for Molecular and Cell Biology (vol. 1). edited byBarnes DN, Sirbasku DA, Sato GH, New York, Alan R. Liss, 1984, pp 275-294
    • (1984) Methods for Molecular and Cell Biology , vol.1 , pp. 275-294
    • Gospodarowicz, D.1
  • 27
    • 0028105969 scopus 로고
    • Binding of heparin and compound Y to endothelial cells stimulates the synthesis of an antithrombotic heparan sulfate proteoglycan
    • PINHAL MA, SILVA IF, LEE TC, et al: Binding of heparin and compound Y to endothelial cells stimulates the synthesis of an antithrombotic heparan sulfate proteoglycan. Braz J Med Biol Res 27:2191-2195, 1994
    • (1994) Braz J Med Biol Res , vol.27 , pp. 2191-2195
    • Pinhal, M.A.1    Silva, I.F.2    Lee, T.C.3
  • 29
    • 0017290721 scopus 로고
    • Electrophoretic behavior of acidic mucopolysaccharides in diamine buffers
    • DIETRICH CP, DIETRICH SMC: Electrophoretic behavior of acidic mucopolysaccharides in diamine buffers. Anal Biochem 70:645-647, 1976
    • (1976) Anal Biochem , vol.70 , pp. 645-647
    • Dietrich, C.P.1    Dietrich, S.M.C.2
  • 30
    • 0034025761 scopus 로고    scopus 로고
    • Effect of epithelial debridement on glycosaminoglycans synthesis by human corneal explants
    • SORIANO ES, CAMPOS MSQ, MICHELACCI YM: Effect of epithelial debridement on glycosaminoglycans synthesis by human corneal explants. Clin Chim Acta 295:41-62, 2000
    • (2000) Clin Chim Acta , vol.295 , pp. 41-62
    • Soriano, E.S.1    Campos, M.S.Q.2    Michelacci, Y.M.3
  • 32
    • 0038015257 scopus 로고    scopus 로고
    • Practical determination of hyaluronan by a new noncompetitive fluorescence-based assay on serum of normal and cirrhotic patients
    • MARTINS JC, PASSEROTTI CC, MACIEL RM, et al: Practical determination of hyaluronan by a new noncompetitive fluorescence-based assay on serum of normal and cirrhotic patients. Anal Biochem 319:65-72, 2003
    • (2003) Anal Biochem , vol.319 , pp. 65-72
    • Martins, J.C.1    Passerotti, C.C.2    Maciel, R.M.3
  • 33
    • 0027479694 scopus 로고
    • Effects of formate and oxalate on chloride absorption in rat distal tubule
    • WANG T, AGULIAN SK, GIEBISCH G, ARONSON PS: Effects of formate and oxalate on chloride absorption in rat distal tubule. Am J Physiol 264 (4 Pt 2):F730-F736, 1993
    • (1993) Am J Physiol , vol.264 , Issue.4 PART 2
    • Wang, T.1    Agulian, S.K.2    Giebisch, G.3    Aronson, P.S.4
  • 34
    • 0033863330 scopus 로고    scopus 로고
    • Identification of hyaluronan as a crystal-binding molecule at the surface of migrating and proliferating MDCK cells
    • VERKOELEN CF, VAN DER BOOM BG, ROMJIN JC: Identification of hyaluronan as a crystal-binding molecule at the surface of migrating and proliferating MDCK cells. Kidney Int 58:1045-1054, 2000
    • (2000) Kidney Int , vol.58 , pp. 1045-1054
    • Verkoelen, C.F.1    Van Der Boom, B.G.2    Romjin, J.C.3
  • 35
    • 0033019604 scopus 로고    scopus 로고
    • Apical secretion of chondroitin sulphate in polarized Madin-Darby canine kidney (MDCK) cells
    • KOLSET SO, VUONG TT, PRYDZ K: Apical secretion of chondroitin sulphate in polarized Madin-Darby canine kidney (MDCK) cells. J Cell Sci 112 (Pt 11):1797-1801, 1999
    • (1999) J Cell Sci , vol.112 , Issue.11 PART , pp. 1797-1801
    • Kolset, S.O.1    Vuong, T.T.2    Prydz, K.3
  • 36
    • 0030019863 scopus 로고    scopus 로고
    • Heparan sulfate expression in polarized epithelial cells: The apical sorting of glypican (GPI-anchored proteoglycan) is inversely related to its heparan sulfate content
    • MERTENS G, VAN DER SCHUEREN B, VAN DEN BERGHE H, DAVID G: Heparan sulfate expression in polarized epithelial cells: the apical sorting of glypican (GPI-anchored proteoglycan) is inversely related to its heparan sulfate content. J Cell Biol 132:487-497, 1996
    • (1996) J Cell Biol , vol.132 , pp. 487-497
    • Mertens, G.1    Van Der Schueren, B.2    Van Den Berghe, H.3    David, G.4
  • 37
    • 0028864367 scopus 로고
    • Proteoglycans in polarized epithelial Madin-Darby canine kidney cells
    • SVENNEVIG K, PRYDZ K, KOLSET SO: Proteoglycans in polarized epithelial Madin-Darby canine kidney cells. Biochem J 311 (Pt 3):881-888, 1995
    • (1995) Biochem J , vol.311 , Issue.3 PART , pp. 881-888
    • Svennevig, K.1    Prydz, K.2    Kolset, S.O.3
  • 38
    • 0035134451 scopus 로고    scopus 로고
    • Basement membrane and interstitial proteoglycans produced by MDCK cells correspond to those expressed in the kidney cortex
    • ERICKSON AC, COUCHMAN JR: Basement membrane and interstitial proteoglycans produced by MDCK cells correspond to those expressed in the kidney cortex. Matrix Biol 19:769-778, 2001
    • (2001) Matrix Biol , vol.19 , pp. 769-778
    • Erickson, A.C.1    Couchman, J.R.2
  • 39
    • 0026050868 scopus 로고
    • A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells
    • STOW JL, DE ALMEIDA JB, NARULA N, et al: A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. J Cell Biol 114:1113-1124, 1991
    • (1991) J Cell Biol , vol.114 , pp. 1113-1124
    • Stow, J.L.1    De Almeida, J.B.2    Narula, N.3
  • 40
    • 0037016690 scopus 로고    scopus 로고
    • Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function
    • EICKELBERG O, CENTRELLA M, REISS M, et al: Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function. J Biol Chem 277:823-829, 2002
    • (2002) J Biol Chem , vol.277 , pp. 823-829
    • Eickelberg, O.1    Centrella, M.2    Reiss, M.3
  • 41
    • 0029814586 scopus 로고    scopus 로고
    • Interactions berween calcium oxalate monhydrate crystals and Madin-Darby canine kidney cells: Endocytosis and cell proliferation
    • KOHJIMOTO Y, EBISUNO S, TAMURA M, OHKAWA T: Interactions berween calcium oxalate monhydrate crystals and Madin-Darby canine kidney cells: Endocytosis and cell proliferation. Urol Res 24:193-199, 1996
    • (1996) Urol Res , vol.24 , pp. 193-199
    • Kohjimoto, Y.1    Ebisuno, S.2    Tamura, M.3    Ohkawa, T.4
  • 42
    • 0030689756 scopus 로고    scopus 로고
    • Adhesion, internalization and metabolism of calcium oxalate monohydrate crystals by renal epithelial cells
    • LIESKE JC, NORRIS R, SWIFT H, TOBACK FG: Adhesion, internalization and metabolism of calcium oxalate monohydrate crystals by renal epithelial cells. Kidney Int 52:1291-1301, 1997
    • (1997) Kidney Int , vol.52 , pp. 1291-1301
    • Lieske, J.C.1    Norris, R.2    Swift, H.3    Toback, F.G.4
  • 43
    • 0032706871 scopus 로고    scopus 로고
    • Molecular detection of heparan sulfate proteoglycan mRNA in rat kidney during calcium oxalate nephrolithiasis
    • IIDA S, INOUE M, YOSHII S, et al: Molecular detection of heparan sulfate proteoglycan mRNA in rat kidney during calcium oxalate nephrolithiasis. J Am Soc Nephrol 10 (Suppl 14):S412-S416, 1999
    • (1999) J Am Soc Nephrol , vol.10 , Issue.14 SUPPL.
    • Iida, S.1    Inoue, M.2    Yoshii, S.3
  • 44
    • 0028898236 scopus 로고
    • Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions
    • LIESKE JC, LEONARD R, TOBACK FG: Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions. Am J Physiol 268:F604-F612, 1995
    • (1995) Am J Physiol , vol.268
    • Lieske, J.C.1    Leonard, R.2    Toback, F.G.3
  • 45
    • 0026583617 scopus 로고
    • Calcium oxalate monohydrate crystals are endocytosed by renal epithelial cells and induce proliferation
    • LIESKE JC, WALSH-REITZ MM, TOBACK FG: Calcium oxalate monohydrate crystals are endocytosed by renal epithelial cells and induce proliferation. Am J Physiol 262 (4 Pt 2):F622-F630, 1992
    • (1992) Am J Physiol , vol.262 , Issue.4 PART 2
    • Lieske, J.C.1    Walsh-Reitz, M.M.2    Toback, F.G.3
  • 46
    • 0033629179 scopus 로고    scopus 로고
    • Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells
    • CAMPOS AH, SCHOR N: Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells. Braz J Med Biol Res 33:111-118, 2000
    • (2000) Braz J Med Biol Res , vol.33 , pp. 111-118
    • Campos, A.H.1    Schor, N.2
  • 47
    • 0042063683 scopus 로고    scopus 로고
    • Protective role of heparin/heparan sulfate on oxalate-induced changes in cell morphology and intracellular calcium
    • IIDA S, ISHIMATSU M, CHIKAMA S, et al: Protective role of heparin/heparan sulfate on oxalate-induced changes in cell morphology and intracellular calcium. Urol Res 31:198-206, 2003
    • (2003) Urol Res , vol.31 , pp. 198-206
    • Iida, S.1    Ishimatsu, M.2    Chikama, S.3


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