Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA

Biochemistry

Volumn 45, Issue 4, 2006, Pages 1338-1344

  Zheng, Yong Gang ^b   Wei, Hui ^a   Ling, Chen ^b   Xu, Min Gang ^b   Wang, En Duo ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ENZYMES; ESCHERICHIA COLI; GENES; MACROMOLECULES; PROTEINS; RNA; SOLUBILITY;

CYTOPLASMIC ARGINYL-TRNA; MACROMOLECULAR COMPLEXES; SINGLE MRNA; SOLUBLE PROTEINS;

ENZYME KINETICS;

ARGININE TRANSFER RNA LIGASE; MESSENGER RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CODON; COMPLEX FORMATION; CONTROLLED STUDY; DELETION MUTANT; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; RNA TRANSLATION; SEQUENCE ALIGNMENT; START CODON; TRANSLATION INITIATION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ARGININE-TRNA LIGASE; BASE SEQUENCE; CELLS, CULTURED; CHROMOSOME MAPPING; CONSERVED SEQUENCE; CYTOPLASM; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BIOSYNTHESIS; RNA PRECURSORS; RNA, MESSENGER; TRANSFORMATION, GENETIC; TUMOR CELLS, CULTURED;

ESCHERICHIA COLI; MAMMALIA; VERTEBRATA;

EID: 31544478796     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051675n     Document Type: Article

References (33)

1. Ibba, M., and Söll, D. (2000) Aminoacyl-tRNA synthesis, Annu. Rev. Biochem. 69, 617-650.
2. Eriani, G., Delarue, M., Poch, O., Gangloff, J., and Moras, D. (1990) Partition of tRNA synthetase into two classes based on mutually exclusive sets of sequence motif, Nature 26, 223-228.
3. Mirande, M. (1991) Aminoacyl-tRNA synthetase family from prokaryotes and eukaryotes: Structural domains and their implications, Prog. Nucleic Acid Res. Mol. Biol. 40, 95-142.
4. Kisselev, L. L., and Wolfson, A. D. (1994) Aminoacyl-tRNA synthetases from higher eukaryotes, Prog. Nucleic Acid Res. Mol. Biol. 48, 83-142.
5. Yang, D. C. (1996) Mammalian aminoacyl-tRNA synthetases, Curr. Top. Cell Regul. 34, 101-136.
6. Quevillon, S., Robinson, J. C., Berthonneau, E., Siatecka, M., and Mirande, M. (1999) Macromolecular assemblage of aminoacyl-tRNA synthetases: Identification of protein-protein interactions and characterization of a core protein, J. Mol. Biol. 285, 183-195.
7. Robinson, J. C., Kerjan, P., and Mirande, M. (2000) Macromolecular assemblage of aminoacyl-tRNA synthetases: Quantitative analysis of protein-protein interactions and mechanism of complex assembly, J. Mol. Biol. 304, 983-994.
8. Rho, S. B., Kim, M. J., Lee, J. S., Seol, W., Motegi, H., Kim, S., and Shiba, K. (1999) Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex, Proc. Natl. Acad. Sci. U.S.A. 96, 4488-4493.
9. Kim, J. Y., Kang, Y. S., Lee, J. W., Kim, H. J., Ahn, Y. H., Park, H., Ko, Y. G., and Kim, S. (2002) p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance, Proc. Natl. Acad. Sci. U.S.A. 99, 7912-7916.
10. Kim, M. J., Park, B. J., Kang, Y. S., Kim, H. J., Park, J. H., Kang, J. W., Lee, S. W., Han, J. M., Lee, H. W., and Kim, S. (2003) Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation, Nat. Genet. 34, 330-336.
11. Lazard, M., Agou, F., Kerjan, P., and Mirande, M. (2000) The tRNA-dependent activation of arginine by arginyl-tRNA synthetase requires inter-domain communication, J. Mol. Biol. 302, 991-1004.
12. Sivaram, P., and Deutscher, M. P. (1990) Existence of two forms of rat liver arginyl-tRNA synthetase suggests channeling of aminoacyl-tRNA for protein synthesis, Proc. Natl. Acad. Sci. U.S.A. 87, 3665-3669.
13. Vellekamp, G., and Deutscher, M. P. (1987) A basic NH2-terminal extension of rat liver arginyl-tRNA synthetase required for its association with high molecular weight complexes, J. Biol. Chem. 262, 9927-9930.
14. Guigou, L., Shalak, V., and Mirande, M. (2004) The tRNA-interacting factor p43 associates with mammalian arginyl-tRNA synthetase but does not modify its tRNA aminoacylation properties, Biochemistry 43, 4592-4600.
15. Park, S. G., Jung, K. H., Lee, J. S., Jo, Y. J., Motegi, H., Kim, S., and Shiba, K. (1999) Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase, J. Biol. Chem. 274, 16673-16676.
16. Nathanson, L., and Deutscher, M. P. (2000) Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex, J. Biol. Chem. 275, 31559-31562.
17. Vellekamp, G., Sihag, R. K., and Deutscher, M. P. (1985) Comparison of the complexed and free forms of rat liver arginyl-tRNA synthetase and origin of the free form, J. Biol. Chem. 260, 9843-9847.
18. Lazard, M., and Mirande, M. (1993) Cloning and analysis of a cDNA encoding mammalian arginyl-tRNA synthetase, a component of the multisynthetase complex with a hydrophobic N-terminal extension, Gene 132, 237-245.
19. Girjes, A. A., Hobson, K., Chen, P., and Lavin, M. F. (1995) Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase, Gene 164, 347-350.
20. Chang, K. J., and Wang, C. C. (2004) Translation initiation from a naturally occurring non-AUG codon in Saccharomyces cerevisiae, J. Biol. Chem. 279, 13778-13785.
21. Tang, H. L., Yeh, L. S., Chen, N. K., Ripmaster, T., Schimmel, P., and Wang, C. C. (2004) Translation of a yeast mitochondrial tRNA synthetase initiated at redundant non-AUG codons, J. Biol. Chem. 279, 49656-49663.
22. Pestova, T. V., Kolupaeva, V. G., Lomakin, I. B., Pilipenko, E. V., Shatsky, I. N., Agol, V. I., and Hellen, C. U. (2001) Molecular mechanisms of translation initiation in eukaryotes, Proc. Natl. Acad. Sci. U.S.A. 98, 7029-7036.
23. Hellen, C. U., and Sarnow, P. (2001) Internal ribosome entry sites in eukaryotic mRNA molecules, Genes Dev. 15, 1593-1612.
24. Meijer, H. A., and Thomas, A. A. (2002) Control of eukaryotic protein synthesis by upstream open reading frames in the 5′-untranslated region of an mRNA, Biochem. J. 367, 1-11.
25. Dever, T. E. (2002) Gene-specific regulation by general translation factors, Cell 108, 545-556.
26. Arg2, Acta Biochim. Biophys. Sin. 31, 226-232.
27. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72, 248-254.
28. Liu, M. F., Huang, Y. W., Wu, J. F., Wang, E. D., and Wang, Y. L. (1999) Effect of the cysteine residues on the activity of arginyl-tRNA synthetase from Escherichia coli, Biochemistry 38, 11006-11011.
29. Ling, C., Yao, Y. N., Zheng, Y. G., Wei, H., Wang, L., Wu, X. F., and Wang, E. D. (2005) The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex, J. Biol. Chem. 280, 34755-34763.
30. Strausberg, R. L., et al. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences, Proc. Natl. Acad. Sci. U.S.A. 99, 16899-16903.
31. Kozak, M. (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes, Cell 44, 283-292.
32. Som, K., and Hardesty, B. (1975) Isolation and partial characterization of an aminoacyl-tRNA synthetase complex from rabbit reticulocytes, Arch. Biochem. Biophys. 166, 507-517.
33. Kuersten, S., and Goodwin, E. B. (2003) The power of the 3′ UTR: Translational control and development, Nat. Rev. Genet. 4, 626-637.