Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 2, 2006, Pages 277-280

  Hajimehdipoor, Homa ^a   Sadeghi, Zhina ^a   Elmi, Sara ^a   Elmi, Azadeh ^a   Ghazi Khansari, Mahmoud ^a   Amanzadeh, Yaghoub ^b   Sadat Ebrahimi, Seyyed Esmaeal ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; PARACETAMOL; PLANT EXTRACT; SWERCHIRIN; SWERTIA LONGIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; IRAN; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; STATISTICAL SIGNIFICANCE; SWERTIA; SWERTIA LONGIFOLIA;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; LIVER; MALE; MICE; PLANT EXTRACTS; PROTECTIVE AGENTS; SWERTIA; XANTHONES;

EID: 31544476899     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.2.0017     Document Type: Article

References (25)

1. Ahmed, M. B., Khater, M. R. (2001) Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage. J. Ethnopharmacol. 75: 169-174
2. Aldridge, W. N. (1981) Mechanism of toxicity: new concepts are required in toxicology. Trends Pharm. Sci. 2: 228-231
3. Asthana, R. K., Sharma, N. K., Kulshreshtha, D. K., Chatterjee, S. K. (1991) A xanthone from Swertia chirayita. Phytochemistry 30: 1037-1039
4. Bajpai, M. B., Asthana, R. K., Sharma, N. K., Chatterjee, S. K., Mukherjee, S. (1991) Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Planta Med. 57: 102-104
5. Bessey, O. A., Lowry, O. H., Brock, M. J. (1946) Method for the rapid determination of alkaline phosphatase with 5 cubic millimetres serum. J. Biol. Chem. 164: 321-329
6. Chenoweth, M. B., Hake, C. L. (1962) The smaller halogenated aliphatic hydrocarbons. Annu. Rev. Pharmacol. 2: 363-398
7. Eriksson, L., Broome, U., Kahn, M., Lindholm, M. (1992) Hepatotoxicity due to repeated intake of low doses of paracetamol. J. Int. Med. 231: 567-570
8. Handa, S. S., Sharma, A. (1990) Hepatoprotective activity of andrographolide against galactosamine and paracetamol intoxication in rats. Indian J. Med. Res. 92: 284-292
9. Handa, S. S., Sharma, A., Chakraborthi, K. K. (1986) Natural products and plants as liver protecting agents. Fitoterapia LVII 5: 307-351
10. Hase, K., Li, J., Basnet, P., Xiong, Q., Takamura, S., Namba, T., Kadota, S. (1997) Hepatoprotective principles of Swertia japonica MAKINO on D-Galactosamine/Lipopolysaccharide-induced liver injury in mice. Chem. Pharm. Bull. 45: 1823-1827
11. Karan, M., Vasisht, K., Handa, S. S. (1999) Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine-induced hepatotoxicity in rats. Phytother. Res. 13: 95-101
12. Kew, M. C. (2000) Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet 355: 591-592
13. Kuma, S., Rex, D. (1991) Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics. Arch. Intern. Med. 151: 1189-1191
14. McLean, A. (1975) Models of liver diseases. In: Karger, B. A. (ed.) New trends in the therapy of liver diseases. S. Karger, Basel, pp 2-12
15. Mitchell, J. (1988) Acetaminophen toxicity. N. Engl. J. Med. 319: 1601-1602
16. Plaa, G. L., Hewitt, W. R. (1989) Detection and evaluation of chemically induced liver injury. In: Hayes, A. W. (ed.) Principles and methods of toxicology. 2nd edn, Raven Press, New York, pp 599-628
17. Potter, W. Z., Thorgeirsson, S. S., Jollow D. J., Mitchell, J. R. (1974) Acetaminophen-induced hepatic necrosis V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology 12: 129-143
18. Prescott, L. F., Roscoe, P., Wright, N., Brown, S. S. (1971) Plasma paracetamol half life and hepatic necrosis in patients with paracetamol overdose. Lancet 1: 519-522
19. Reitman, S., Frankel, A. S. (1957) A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 28: 56-63
20. Saxena, A. M., Bajpai, M. B., Mukherjee, S. K. (1991) Swerchirin induced blood sugar lowering of streptozotocin treated hyperglycemic rats. Indian J. Exp. Biol. 29: 674-675
21. Slater, T. F. (1965) Biochemical studies on liver injury. In: Biochemical mechanism of liver injury. Academic Press, London, pp 1-44
22. Thompsen, M., Loft, S., Roberts, D., Poulsen, H. (1995) Cytochrome P450 2E1 inhibition by propylene glycol prevents acetaminophen hepatotoxicity in mice without cytochrome P450 1A2 inhibition. Pharmacol. Toxicol. 76: 395-399
23. Ya, B. Q., Gen, X. P. (1998) Four xanthones from Swertia calycina Franch. Pharm. Pharmacol. Commun. 4: 595-596
24. Ya, B. Q., Nian, L. C., Li, C., Gen, X. P. (1999) Protective effect of swerchirin on hematopoiesis in 60Co-irradiated mice. Phytomedicine 6: 85-88
25. Zhou, H. M., Liu, Y. L., Blaskó, G., Cordell, G. A. (1989) Swertia-bisxanthone-I from Swertia macrosperma. Phytochemistry 28: 3569-3571