Effect of L-carnitine on the kinetics of carnitine, acylcarnitines and butyrobetaine in long-term haemodialysis

Nephrology Dialysis Transplantation

Volumn 21, Issue 2, 2006, Pages 450-458

  Vernez, Laurence ^a   Dickenmann, Michael ^a   Steiger, Jürg ^a   Wenk, Markus ^a   Krähenbühl, Stephan ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Acylcarnitines; Butyrobetaine; Carnitine; Haemodialysis; Liquid chromatography tandem mass spectrometry

Indexed keywords

ACYLCARNITINE; CARNITENE SIGMA TAU; CARNITINE; GAMMA BUTYROBETAINE; PROPIONYLCARNITINE;

ADULT; AGED; APHERESIS; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG MECHANISM; FEMALE; HEMODIALYSIS; HUMAN; KINETICS; LIQUID CHROMATOGRAPHY; LONG TERM CARE; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STEADY STATE; SUPPLEMENTATION; TANDEM MASS SPECTROMETRY;

ADULT; AGED; BETAINE; CARNITINE; FEMALE; HUMANS; MALE; MIDDLE AGED; RENAL DIALYSIS; TIME FACTORS;

EID: 31544469481     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi257     Document Type: Article

References (27)

1. Hoppel C. The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis 2003; 41: S4-S12
2. Roe CR, Hoppel CL, Stacey TE, Chalmers RA, Tracey BM, Millington DS. Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups. Arch Dis Child 1983; 58: 916-920
3. Friolet R, Hoppeler H, Krahenbuhl S. Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J Clin Invest 1994; 94: 1490-1495
4. Hoppel CL. Determination of carnitine. In: Techniques in Diagnostic Human Biochemical Genetics: A Laboratory Manual. Wiley-Liss, New York 1991; 309-326
5. Vernez L, Wenk M, Krahenbuhl S. Determination of carnitine and acylcarnitines in plasma by high-performance liquid chromatography/ electrospray ionization ion trap tandem mass spectrometry. Rapid Commun Mass Spectrom 2004; 18: 1233-1238
6. Evans AM, Faull R, Fornasini G et al. Pharmacokinetics of L-carnitine in patients with end-stage renal disease undergoing long-term hemodialysis. Clin Pharmacol Ther 2000; 68: 238-249
7. Bellinghieri G, Savica V, Mallamace A et al. Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Am J Clin Nutr 1983; 38: 523-531
8. Hiatt WR, Koziol BJ, Shapiro JI, Brass EP. Carnitine metabolism during exercise in patients on chronic hemodialysis. Kidney Int 1992; 41: 1613-1619
9. Bellinghieri G, Santoro D, Calvani M, Mallamace A, Savica V. Carnitine and hemodialysis. Am J Kidney Dis 2003; 41: S116-S122
10. Ahmad S, Robertson HT, Golper TA et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990; 38: 912-918
11. Hurot JM, Cucherat M, Haugh M, Fouque D. Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review. J Am Soc Nephrol 2002; 13: 708-714
12. Leschke M, Rumpf KW, Eisenhauer T et al. Quantitative assessment of carnitine loss during hemodialysis and hemofiltration. Kidney Int Suppl 1983; 16: S143-S146
13. Panzetta G, Bonadonna G, Giovene P, de Grandis D. Carnitine kinetics during dialysis. Evidence of unilateral transport from tissues to plasma. Nephron 1985; 41: 230-234
14. Jackson JM, Lee HA. L-Carnitine and acetyl-L-carnitine status during hemodialysis with acetate in humans: A kinetic analysis. Am J Clin Nutr 1996; 64: 922-927
15. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt/V: An analysis of error. J Am Soc Nephrol 1993; 4: 1205-1213
16. Kloppenburg WD, Stegeman CA, Hooyschuur M, van der Ven J, de Jong PE, Huisman RM. Assessing dialysis adequacy and dietary intake in the individual hemodialysis patient. Kidney Int 1999; 55: 1961-1969
17. Tanswell P, Heinzel G, Weisenberger H, Roth W. Pharmacokinetic-pharmacodynamic and metabolite modeling with TopFit. Int J Clin Pharmacol Ther 1995; 33: 550-554
18. Rebouche CJ, Engel AG. Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. Evidence for alterations in tissue carnitine transport. J Clin Invest 1984; 73: 857-867
19. Inoue F, Terada N, Nakajima H et al. Effect of sports activity on carnitine metabolism. Measurement of free carnitine, gamma-butyrobetaine and acylcarnitines by tandem mass spectrometry. J Chromatogr B Biomed Sci Appl 1999; 731: 83-88
20. Minkler PE, Hoppel CL. Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. Anal Biochem 1993; 212: 510-518
21. Frenkel EP, Kitchens RL. Intracellular localization of hepatic propionyl-CoA carboxylase and methylmalonyl-CoA mutase in humans and normal and vitamin B12 deficient rats. Br J Haematol 1975; 31: 501-513
22. Brass EP, Beyerinck RA. Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids. Biochem J 1988; 250: 819-825
23. Maeda K, Shinzato T, Kobayakawa H. Effects of L-carnitine administration on short-chain fatty acid (acetic acid) and long-chain fatty acid metabolism during hemodialysis. Nephron 1989; 51: 355-361
24. Vaz FM, Wanders RJ. Carnitine biosynthesis in mammals. Biochem J 2002; 361: 417-429
25. Sandor A, Minkler PE, Ingalls ST, Hoppel CL. An enzymatic method for the determination of butyrobetaine via conversion to carnitine after isolation by high performance liquid chromatography. Clin Chim Acta 1988; 176: 17-27
26. Berardi S, Stieger B, Wachter S, O'Neill B, Krahenbuhl S. Characterization of a sodium-dependent transport system for butyrobetaine into rat liver plasma membrane vesicles. Hepatology 1998; 28: 521-525
27. Tamai I, Ohashi R, Nezu J et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 1998; 273: 20 378-20 382