Identification of neural stem cells in adult human brain: Its implication in the strategy for repairing the damaged central nervous system

Clinical Neurology

Volumn 45, Issue 11, 2005, Pages 871-873

  Okano, Hideyuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adult human brain; Adult neurogenesis; Musashi 1; Neural stem cell; Regeneration

Indexed keywords

BRAIN INJURY; CELL DIFFERENTIATION; CELL REGENERATION; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; HUMAN; HUMAN CELL; MULTIPOTENT STEM CELL; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INJURY; NEURAL STEM CELL; OLIGODENDROGLIA; PHENOTYPE; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; TISSUE DISTRIBUTION;

ADULT; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; HUMANS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURONS; RNA-BINDING PROTEINS; STEM CELLS;

EID: 31544463016     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Ramón y Cajal S: Degeneration and regeneration of the nervous system (Translated by RM Day from the 1913 Spanish edition). Oxford University Press, Oxford, 1928
2. Okano H: The stem cell biology of the central nervous system. J Neurosci Res 2002; 69: 698-707
3. Sakakibara S, Imai T, Aruga J, et al: Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Dev Biol 1996; 176: 230-242
4. Sakakibara S, Okano H: Expression of neural RNA-binding proteins in the post-natal CNS: implication of their roles in neural and glial cells development. J Neurosci 1997; 17: 8300-8312
5. Kaneko Y, Sakakibara S, Imai T, et al: An evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci 2000; 22: 139-153
6. Nakamura M, Okano H, Blendy J, et al: MUSASHI, a neural RNA-binding protein required for Drosophila adult external sensory organ development. Neuron 1994; 13: 67-81
7. Pincus DW, Keyoung H, Restelli C, et al: FGF2/BDNF-responsive neuronal progenitor cells in the adult human subependyma. Annals of Neurol 1998; 43: 576-585
8. Roy NS, Wang S, Jiang L, et al: In vitro neurogenesis by neural progenitor cells isolated from the adult human hippocampus. Nat Med 2000; 6: 271-278
9. Roy NS, Benraiss A, Wang S, et al: Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J Neurosci Res 2000; 59: 321-331
10. Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al: Neurogenesis in the adult human hippocampus. Nat Med 1998; 4: 1313-1317