DNA repair and neurodegeneration

Clinical Neurology

Volumn 45, Issue 11, 2005, Pages 979-981

  Onodera, Osamu ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Aprataxia; DNA repair; Recessive ataxias; Spinocerebellar ataxia

Indexed keywords

EXODEOXYRIBONUCLEASE III; SCAFFOLD PROTEIN; SINGLE STRANDED DNA;

APRAXIA; ATAXIA; CEREBELLAR ATAXIA; CONFERENCE PAPER; CONTROL SYSTEM; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENE; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOALBUMINEMIA; NERVE DEGENERATION; QUALITY CONTROL;

APRAXIAS; DNA REPAIR; DNA, SINGLE-STRANDED; HUMANS; NEURODEGENERATIVE DISEASES; SACCADES; SPINOCEREBELLAR ATAXIAS;

EID: 31544457333     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Date H, Onodera O, Tanaka H, et al: Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat Genet 2001; 29: 184-188
2. Moreira MC, Barbot C, Tachi N, et al: The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat Genet 2001; 29: 189-193
3. Sparks DL: The brainstem control of saccadic eye movements. Nat Rev Neurosci 2002; 3: 952-964
4. Takagi M, Zee DS, Tamargo RJ: Effects of lesions of the oculomotor vermis on eye movements in primate: saccades. J Neurophysiol 1998; 80: 1911-1931
5. Goossens HH, Van Opstal AJ: Blink-perturbed saccades in monkey. II. Superior colliculus activity. J Neurophysiol 2000; 83: 3430-3452
6. Rambold H, Sprenger A, Helmchen C: Effects of voluntary blinks on saccades, vergence eye movements, and saccade-vergence interactions in humans. J Neurophysiol 2002; 88: 1220-1233
7. Brenner C: Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. Biochemistry 2002; 41: 9003-9014
8. Date H, Igarashi S, Sano Y, et al: The FHA domain of aprataxin interacts with the C-terminal region of XRCC1. Biochem Biophys Res Commun 2004; 325: 1279-1285
9. Sano Y, Date H, Igarashi S, et al: Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein. Ann Neurol 2004; 55: 241-249
10. Caldecott KW: Mammalian DNA single-strand break repair: an X-ra (y) ted affair. Bioessays 2001; 23: 447-455