Tacrolimus combined with mycophenolate mofetil can effectively reverse C4d-positive steroid-resistant acute rejection in Chinese renal allograft recipients

Nephrology Dialysis Transplantation

Volumn 21, Issue 2, 2006, Pages 510-517

  Sun, Qiquan ^a   Liu, Zhi Hong ^a   Yin, Guang ^a   Chen, Huiping ^a   Chen, Jinsong ^a   Ji, Shuming ^a   Li, Lei Shi ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Acute rejection; C4d; Kidney transplantation; Mycophenolate mofetil; Tacrolimus

Indexed keywords

BASILIXIMAB; COMPLEMENT COMPONENT C4D; CYCLOSPORIN A; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; STEROID; TACROLIMUS; UNCLASSIFIED DRUG; ZANAPAX;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ECONOMIC ASPECT; FEMALE; GRAFT FAILURE; HUMAN; IMMUNOADSORPTION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; MALE; OUTCOMES RESEARCH; PNEUMONIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STAINING; STATISTICAL ANALYSIS;

ACUTE DISEASE; ADULT; ANTIGENS, CD4; CHINA; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; METHYLPREDNISOLONE; MIDDLE AGED; MYCOPHENOLIC ACID; REMISSION INDUCTION; RETROSPECTIVE STUDIES; TACROLIMUS;

EID: 31544455528     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfk027     Document Type: Article

References (20)

1. Feucht HE, Opelz G. The humoral immune response towards HLA class II determinants in renal transplantation. Kidney Int 1996; 50: 1464-1475
2. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708-714
3. Karpinski M, Rush D, Jeffery J et al. Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity cross-match. J Am Soc Nephrol 2001; 12: 2807-2814
4. Bohmig GA, Regele H, Exner M et al. C4d-positive acute humoral renal allograft rejection: Effective treatment by immunoadsorption. J Am Soc Nephrol 2001; 12: 2482-2489
5. Mauiyyedi S, Crespo M, Collins AB et al. Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classication. J Am Soc Nephrol 2002; 13: 779-787
6. Moll S, Pascual M. Detection of alloantibody deposition in allografts: capillary C4d deposition as a marker of humoral rejection. Curr opin organ transplant 2004; 9: 29-35
7. Nickeleit V, Mihatsch M. Kidney transplants, antibodies and rejection: is C4d a magic marker? Nephrol Dial Transplant 2003; 18: 2232-2239
8. Herzenberg AM, Gill JS, Djurdjew O, Magil AB. C4d deposition in acute rejection: An independent long-term prognostic factor. J Am Soc Nephrol 2002; 13: 234-241
9. Pascual M, Saidman S, Tolkoff-Rubin N et al. Plasma exchange and tacrolimus-mycophenolate rescue for acute humoral rejection in kidney transplantation. Transplantation 1998; 66: 1460-1464
10. Crespo M, Pascual M, Tolkoff-Rubin N et al. Acute humoral rejection in renal allograft recipients: Incidence, serology and clinical characteristics. Transplantation 2001; 71: 652-658
11. Bock HA, Steroid-resistant kidney transplant rejection: Diagnosis and treatment. J Am Soc Nephrol 2001; 12: S48-S52
12. Böhmig GA, Exner M, Habicht A et al. Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002; 13: 1091-1099
13. Sun Q, Liu Z, Yin G et al. Detectable circulating antiendothelial cell antibodies in renal allograft recipient with C4d-positive acute rejection: A report of three cases. Transplantation 2005; 79: 1759-1762
14. Montgomery RA, Hardy MA, Jordan SC et al. Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols. Transplantation 2004; 78: 181-185
15. Nickeleit V, Zeiler M, Gudat F et al. Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242-251
16. Nickeleit V, Vamvakas EC, Pascual M et al. The prognostic significance of specific arterial lesions in acute renal allograft rejection. J Am Soc Nephrol 1998; 9: 1301-1308
17. Vangelista A, Frasca GM, Nanni Costa A, Stefoni S, Bonomini V. Value of plasma exchange in renal transplant rejection induced by specific anti-HLA antibodies. Trans Am Soc Artif Intern Organs 1982; 28: 599-603
18. Kimball JA, Pescovitz MD, Book BK, Norman DJ. Reduced human IgG anti-ATGAM antibody formation in renal transplant recipients receiving mycophenolate mofetil. Transplantation 1995; 60: 1379-1383
19. Allen NH, Dyer P, Geoghegan T, Harris K, Lee HA, Slapak M. Plasma exchange in acute renal allograft rejection. A controlled trial. Transplantation 1983; 35: 425-428
20. Sun Q, Li L, Ji S et al. Variation of CD4+ and CD8+ T lymphocytes as predictor of outcome in renal allograft recipients who developed acute respiratory distress syndrome caused by cytomegalovirus pneumonia. Transplant Proc 2005; 37: 2118-2121