Long-term clinical outcome of phase IIb clinical trial of percutaneous injection with holmium-166/chitosan complex (milican) for the treatment of small hepatocellular carcinoma

Clinical Cancer Research

Volumn 12, Issue 2, 2006, Pages 543-548

  Kim, Ja Kyung ^a   Han, Kwang Hyub ^a   Lee, Jong Tae ^a   Paik, Yong Han ^a   Ahn, Sang Hoon ^a   Lee, Jong Doo ^a   Lee, Kwan Sik ^a   Chon, Chae Yoon ^a   Moon, Young Myoung ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHITOSAN; HOLMIUM; HOLMIUM 166; MILICAN; UNCLASSIFIED DRUG;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACKACHE; BONE MARROW DEPRESSION; CANCER RECURRENCE; CANCER SIZE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; FACE EDEMA; FEMALE; FEVER; FOLLOW UP; HEADACHE; HEMATURIA; HUMAN; INJECTION SITE PAIN; ISOTOPE LABELING; JAUNDICE; LEUKOPENIA; LIVER CELL CARCINOMA; LIVER TOXICITY; MALE; NAUSEA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RASH; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CHITOSAN; FEMALE; HOLMIUM; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; RADIOISOTOPES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 31544448061     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-1730     Document Type: Article

References (29)

1. Ebara M, Ohto M, Sugiura N, et al. Percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Study of 95 patients. J Gastroenterol Hepatol 1990;5:616-26.
2. Livraghi T, Vettori C. Percutaneous ethanol injection therapy of hepatoma. Cardiovasc Intervent Radiol 1990;13:146-52.
3. Seifert JK, Junginer T, Morris DL. A collective review of the world literature on hepatic cryotherapy. J R Coll Surg Edinb 1998;43:141-54.
4. Rossi S, Di Stasi M, Buscarini E, et al. Percutaneous radiofrequency ablation in the treatment of hepatic cancer. Am J Roentgenol 1996;167:759-68.
5. Heisterkamp J, van Hillegersberg R, Ijzermans JN. Interstitial laser coagulation for hepatic tumors. Br J Surg 1999;86:293-304.
6. Raoul JL, Bourguet P, Bretagnr JF, et al. Hepatic artery injection of I-131-labeled lipiodol. Part I. Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology 1988;168:541-5.
7. Andrews JC, Walker SC, Ackermann RJ, Cotton LA, Ensminger WD, Shapiro B. Hepatic radioembolization with Yttrium-90 containing glass microspheres: preliminary results and clinical follow-up. J Nucl Med 1994;35:1637-44.
8. Geschwind JFH, Salem R, Carr BI, et al. Yttrium-90 microsphere for the treatment of hepatocellular carcinoma. Gastroenterology 2004;127:5194-205.
9. Suzuki YS, Momose Y, Higashi N, et al. Biodistribution and kinetics of Ho-166-chitosan complex in rats and mice. J Nucl Med 1998;39:2161-6.
10. Volkert WA, Goeckerler WF, Egrharde GJ, Ketring AR. Therapeutic radionuclides: production and decay properties consideration. J Nucl Med 1991;32:174-85.
11. Brown RF, Lidesmith LC, Day DE. 166-Holmium-containing glass for internal radiotherapy of tumors. Int J Radiat Appl Instrum Part B 1991;18:783-90.
12. Turner JH, Claringbold PG, Klemp PFB, et al. Ho-166-microsphere liver radiotherapy: a preclinical SPECT dosimetry study in the pig. Nucl Med Commun 1994;15:545-53.
13. Mumper RJ, Ryo UY, Jay M. Neutron-activated Holmium-166-poly (L-lactic acid) microspheres: a potential agent for the internal radiation therapy of hepatic tumors. J Nucl Med 1991;32:2139-43.
14. Nijsen JFW, Zonnenberg BA, Woittiez JRW, et al. Holmium-166 poly lactic acid microspheres applicable for intra-arterial radionuclide therapy of hepatic malignancies: effects of preparation and neutron activation techniques. Eur J Nucl Med 1999;26:699-704.
15. Lee YH, Lee JT, Yoo HS, et al. Effect of Holmium-166 injection into hepatocellular carcinomas (SK-HEP1) heterotransplanted in mice. J Korean Radiol Soc 1998;38:83-91.
16. Bruix J, Sherman M, Llovet JM, et al. The EASL Panel of Experts on HCC. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. J Hepatol 2001;35:421-30.
17. Paik YH, Han KH, Lee JT, Lee DY, Chon CY, Moon YM. Treatment of small hepatocellular carcinoma with percutaneous Holmium injection: comparison with segmental transcatheter arterial chemoembolization [abstract]. J Gastroenterol Hepatol 2000;15:F11.
18. Muzzarelli R, Baldassarre V, Conti F, Ferrara P, Biagini G. Biological activity of chitosan: ultrastructural study. Biomaterials 1988;9:247-52.
19. Park KB. Therapeutic feasibility of various diseases using Holmium-166 chitosan complex. Kor J Nucl Medicine 1997;31:123.
20. Johnson LS, Yanch JC, Shortkroff S, Barnes CL, Sitzer AI, Sledge CB. Beta-particle dosimetry in radiation synovectomy. Eur J Nucl Med 1995;22:977-88.
21. Lee JD, Yang WI, Lee MG, et al. Effective local control of malignant melanoma by intratumoural injection of a beta-emitting radionuclide. Eur J Nucl Med 2002;29:221-30.
22. Llovet JM, Vilana R, Bru C, et al. Increased risk of tumor seeding after radiofrequency thermal ablation for single hepatocellular carcinoma. Hepatology 2001;33:1124-9.
23. Livraghi T, Solbiati L, Meloni MF, Gazelle GS, Halpern EF, Goldberg SN. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology 2003;226:441-51.
24. Bartolozzi C, Lencioni R, Caramella D, et al. Hepatocellular carcinoma: CT and MR features after transcatheter arterial embolization and percutaneous ethanol injection. Radiology 1994;191:123-8.
25. Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002;35:519-24.
26. Livraghi T, Giorgio A, Marin G, et al. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 1995;197:101-8.
27. Sala M, Llovet JM, Vilana R, et al. The Barcelona Clinic Liver Cancer (BCLC) Group. Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma. Hepatology 2004;40:1352-60.
28. Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 1999;210:655-61.
29. Tateishi R, Shiina S, Teratani T, et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma: an analysis of 1000 cases. Cancer 2005;103:1201-9.