Computational evidence for protein-mediated fatty acid transport across the sarcolemma

Biochemical Journal

Volumn 393, Issue 3, 2006, Pages 669-678

  Musters, Mark W J M ^a   Bassingthwaighte, James B ^b   Van Riel, Natal A W ^a   Van Der Vusse, Ger J ^c  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b University of Washington   (United States)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Extracellular matrix; Fatty acid; Membrane protein; Modelling; Plasma albumin

Indexed keywords

BLOOD; CELL MEMBRANES; COMPUTATIONAL METHODS; COMPUTER SIMULATION; FATTY ACIDS; MATHEMATICAL MODELS; OXIDATION; PHYSIOLOGY;

EXTRACELLULAR MATRIX; MEMBRANE PROTEIN; MODELING; PLASMA ALBUMIN;

PROTEINS;

ALBUMIN RECEPTOR; BINDING PROTEIN; FATTY ACID TRANSPORT FACILITATING PROTEIN COMPLEX; LONG CHAIN FATTY ACID; MEMBRANE PROTEIN; SARCOLEMMA ASSOCIATED PROTEIN; SERUM ALBUMIN; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; COMPLEX FORMATION; COMPUTER MODEL; DIFFUSION; EXTRACELLULAR MATRIX; FATTY ACID TRANSPORT; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE METABOLISM; PREDICTION; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN FUNCTION; SARCOLEMMA;

BIOLOGICAL TRANSPORT, ACTIVE; COMPUTER SIMULATION; DIFFUSION; FATTY ACIDS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MYOCARDIUM; RECEPTORS, ALBUMIN; SARCOLEMMA;

EID: 31544448005     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050869     Document Type: Article

References (47)

1. Bing, R. J., Siegel, A., Ungar, I. and Gilbert, M. (1954) Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism. Am. J. Med. 16, 504-515
2. van der Vusse, G. J., Glatz, J. F., Stam, H. C. and Reneman, R. S. (1992) Fatty acid homeostasis in the normoxic and ischemic heart. Physiol. Rev. 72, 881-940
3. Richieri, G. V., Anel, A. and Kleinfeld, A. M. (1993) Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32, 7574-7580
4. Broring, K., Haest, C. W. and Deuticke, B. (1989) Translocation of oleic acid across the erythrocyte membrane. Evidence for a fast process. Biochim. Biophys. Acta 986, 321-331
5. Cooper, R. B., Noy, N. and Zakim, D. (1989) Mechanism for binding of fatty acids to hepatocyte plasma membranes. J. Lipid Res. 30, 1719-1726
6. Hamilton, J. A., Guo, W. and Kamp, F. (2002) Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins? Mol. Cell. Biochem. 239, 17-23
7. Zakim, D. (1996) Fatty acids enter cells by simple diffusion. Proc. Soc. Exp. Biol. Med. 212, 5-14
8. Storch, J., Lechene, C. and Kleinfeld, A. M. (1991) Direct determination of free fatty acid transport across the adipocyte plasma membrane using quantitative fluorescence microscopy. J. Biol. Chem. 266, 13473-13476
9. Harmon, C. M. and Abumrad, N. A. (1993) Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J. Membr. Biol. 133, 43-49
10. Luiken, J. J. F. P., Van Nieuwenhoven, F. A., America, G., van der Vusse, G. J. and Glatz, J. F. C. (1997) Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: involvement of sarcolemmal proteins. J. Lipid Res. 38, 745-758
11. van der Vusse, G. J., van Bilsen, M. and Glatz, J. F. C. (2000) Cardiac fatty acid uptake and transport in health and disease. Cardiovasc. Res. 45, 279-293
12. Pelsers, M. M. A. L., Lutgerink, J. T., van Nieuwenhoven, F. A., Tandon, N. N., van der Vusse, G. J., Arends, J.-W., Hoogenboom, H. R. and Glatz, J. F. C. (1999) A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes. Biochem. J. 337, 407-414
13. Brinkmann, J. F., Abumrad, N. A., Ibrahimi, A., van der Vusse, G. J. and Glatz, J. F. C. (2002) New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36. Biochem. J. 367, 561-570
14. Ockner, R. K., Weisiger, R. A. and Gollan, J. L. (1983) Hepatic uptake of albumin-bound substances: albumin receptor concept. Am. J. Physiol. 245, G13-G18
15. Hutter, J. F., Piper, H. M. and Spieckermann, P. G. (1984) Kinetic analysis of myocardial fatty acid oxidation suggesting an albumin receptor mediated uptake process. J. Mol. Cell Cardiol. 16, 219-226
16. Rose, H., Hennecke, T. and Kammermeier, H. (1990) Sarcolemmal fatty acid transfer in isolated cardiomyocytes governed by albumin/membrane-lipid partition. J. Mol. Cell Cardiol. 22, 883-892
17. Kamp, F., Westerhoff, H. V. and Hamilton, J. A. (1993) Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 32, 11074-11086
18. Kleinfeld, A. M., Chu, P. and Romero, C. (1997) Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. Biochemistry 36, 14146-14158
19. Hamilton, J. A. (1998) Fatty acid transport: difficult or easy? J. Lipid Res. 39, 467-481
20. Luiken, J. J. F. P., Koonen, D. P. Y., Willems, J., Zorzano, A., Becker, C., Fischer, Y., Tandon, N. N., van der Vusse, G. J., Bonen, A. and Glatz, J. F. C. (2002) Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular resdistribution of FAT/CD36. Diabetes 51, 3113-3119
21. Barta, E., Sideman, S. and Bassingthwaighte, J. B. (2000) Facilitated diffusion and membrane permeation of fatty acid in albumin solutions. Ann. Biomed. Eng. 28, 331-345
22. van der Vusse, G. J., Roemen, T. H., Prinzen, F. W., Coumans, W. A. and Reneman, R. S. (1982) Uptake and tissue content of fatty acids in dog myocardium under normoxic and ischemic conditions. Circ. Res. 50, 538-546
23. Vyska, K., Meyer, W., Stremmel, W., Notohamiprodjo, G., Minami, K., Machulla, H. J., Gleichmann, U., Meyer, H. and Korfer, R. (1991) Fatty acid uptake in normal human myocardium. Circ. Res. 69, 857-87
24. Musters, M. W. J. M., Bassingthwaighte, J. B., Panday, V., van Riel, N. A. W. and van der Vusse, G. J. (2004) Computational modeling of cardiac fatty acid uptake and utilization. In Lipobiology (van der Vusse, G. J., ed.), pp. 173-224, Elsevier, Amsterdam
25. Hamilton, J. A., Johnson, R. A., Corkey, B. and Kamp, F. (2001) Fatty acid transport: the diffusion mechanism in model and biological membranes. J. Mol. Neurosci. 16, 99-108
26. Spector, A. A., Fletcher, J. E. and Ashbrook, J. D. (1971) Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants. Biochemistry 10, 3229-3232
27. Ashbrook, J. D., Spector, A. A., Santos, E. C. and Fletcher, J. E. (1975) Long chain fatty acid binding to human plasma albumin. J. Biol. Chem. 250, 2333-2338
28. Weisiger, R., Gollan, J. and Ockner, R. (1981) Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances. Science (Washington, D.C.) 211, 1048-1051
29. Hamilton, J. A. and Kamp, F. (1999) How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes 48, 2255-2269
30. Abumrad, N., Harmon, C. and Ibrahimi, A. (1998) Membrane transport of long-chain fatty acids: evidence for a facilitated process. J. Lipid Res. 39, 2309-2318
31. Abumrad, N., Coburn, C. and Ibrahimi, A. (1999) Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. Biochim. Biophys. Acta 1441, 4-13
32. Richieri, G. V., Ogata, R. T. and Kleinfeld, A. M. (1995) Thermodynamics of fatty acid binding to fatty acid-binding proteins and fatty acid partition between water and membranes measured using the fluorescent probe ADIFAB. J. Biol. Chem. 270, 15076-15084
33. Popov, D., Hasu M., Ghinea N., Simionescu, N. and Simionescu, M. (1992) Cardiomyocytes express albumin binding proteins. J. Mol. Cell. Cardiol. 24, 989-1002
34. Vink, H. and Duling, B. R. (2000) Capillary endothelial surface layer selectively reduces plasma solute distribution volume. Am. J. Physiol. Heart Circ. Physiol. 278, H285-H289
35. Richieri, G. V. and Kleinfeld, A. M. (1995) Unbound free fatty acid levels in human serum. J. Lipid Res. 36, 229-240
36. Kamp, F., Guo, W., Souto, R., Pilch, P. F., Corkey, B. E. and Hamilton, J. A. (2003) Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J. Biol. Chem. 278, 7988-7995
37. Cupp, D., Kampf, J. P. and Kleinfeld, A. M. (2004) Fatty acid-albumin complexes and the determination of the transport of long chain free fatty acids across membranes. Biochemistry 43, 4473-4481
38. Rose, H., Hennecke, T. and Kammermeier, H. (1989) Is fatty acid uptake in cardiomyocytes determined by physicochemical fatty acid partition between albumin and membranes? Mol. Cell. Biochem. 88, 31-36
39. Schaffer, J. E. and Lodish, H. F. (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79, 427-436
40. Storch, J. and Thumser, A. E. (2000) The fatty acid transport function of fatty acid-binding proteins. Biochim. Biophys. Acta 1486, 28-44
41. Stremmel, W., Strohmeyer, G., Borchard, F., Kochwa, S. and Berk, P. D. (1985) Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. Proc. Natl. Acad. Sci. U.S.A. 82, 4-8
42. Bassingthwaighte, J. B., Noodleman, L., van der Vusse, G. J. and Glatz, J. F. C. (1989) Modeling of palmitate transport in the heart. Mol. Cell. Biochem. 88, 51-58
43. Brandes, R., Ockner, R. K., Weisiger, R. A. and Lysenko, N. (1982) Specific and saturable binding of albumin to rat adipocytes: modulation by epinephrine and possible role in free fatty acid transfer. Biochem. Biophys. Res. Commun. 105, 821-827
44. Luby-Phelps, K. (2000) Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area. Int. Rev. Cytol. 192, 189-221
45. Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. and Watson, J. D. (1994). Membrane structure. In Molecular Biology of the Cell (Robertson, M., Adams, R. and Goertzen, D., eds.), pp. 478-506, Garland Publishing, New York
46. Weisiger, R. A., Pond, S. and Bass, L. (1991) Hepatic uptake of protein-bound ligands: extended sinusoidal perfusion model. Am. J. Physiol. 261, G872-G884
47. Demant, E. J., Richieri, G. V. and Kleinfeld, A. M. (2002) Stopped-flow kinetic analysis of long-chain fatty acid dissociation from bovine serum albumin. Biochem. J. 363, 809-815