Utility of human/human-derived reagents in drug discovery and development: An industrial perspective

Environmental Toxicology and Pharmacology

Volumn 21, Issue 2 SPEC. ISS., 2006, Pages 179-183

  Hyland, Ruth ^a   Jones, Barry ^a   Van De Waterbeemd, Han ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Drug discovery; Drug drug interactions (DDI); Human reagents; In silico ADME

Indexed keywords

CELL LINE; CELL MEMBRANE PERMEABILITY; COLON ADENOCARCINOMA; COMBINATORIAL CHEMISTRY; COMPUTER MODEL; DRUG BINDING; DRUG DEVELOPMENT; DRUG INHIBITION; DRUG INTERACTION; DRUG METABOLISM; DRUG PENETRATION; DRUG SYNTHESIS; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER MICROSOME; PHARMACOKINETICS; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVIEW; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 31544447176     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2005.07.007     Document Type: Article

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