Update on adverse drug events associated with parenteral iron

Nephrology Dialysis Transplantation

Volumn 21, Issue 2, 2006, Pages 378-382

  Chertow, Glenn M ^a   Mason, Phillip D ^b   Vaage Nilsen, Odd ^c   Ahlmén, Jarl ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c Sahlgren's University Hospital ^*  (Denmark)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adverse drug events; Iron dextran; Iron sucrose; Molecular weight; Parenteral iron; Sodium ferric gluconate complex

Indexed keywords

COSMOFER; FERRIC GLUCONATE; FERRIC HYDROXIDE SUCROSE; IRON DEXTRAN;

ABDOMINAL PAIN; ANAPHYLAXIS; ANEMIA; ARTICLE; BACKACHE; BRONCHOSPASM; CHRONIC KIDNEY FAILURE; COMA; CONFIDENCE INTERVAL; CONTROLLED STUDY; DERMATITIS; DOSE RESPONSE; DRUG COST; DRUG ERUPTION; DRUG FATALITY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG SURVEILLANCE PROGRAM; DYSPNEA; FLUSHING; HEALTH CARE COST; HEALTH SURVEY; HEART ARREST; HEMODIALYSIS; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MOLECULAR WEIGHT; MORTALITY; NAUSEA; PRIORITY JOURNAL; PRURITUS; RESPIRATION DEPRESSION; SIDE EFFECT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SWEATING; THORAX PAIN; URTICARIA; VOMITING; WORLD HEALTH ORGANIZATION;

ADVERSE DRUG REACTION REPORTING SYSTEMS; FERRIC COMPOUNDS; HEMATINICS; HUMANS; IRON-DEXTRAN COMPLEX; SUCROSE;

EID: 31544444964     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi253     Document Type: Article

References (18)

1. NKF-K/DOQI clinical practice guidelines for anemia of chronic kidney disease: Update 2000. Am J Kidney Dis 2001; 37 [1 Suppl 1]: S182-S238
2. Li S, Foley RN, Gilbertson DT, Liu J, Collins AJ. Clinical factors associated with achieving K/DOQI hemoglobin targets in hemodialysis patients. Int Urol Nephrol 2003; 35: 399-405
3. Kooistra MP, Niemantsverdriet EC, van Es A, Mol-Beermann NM, Struyvenberg A, Marx JJ. Iron absorption in erythropoietin-treated haemodialysis patients: Effects of iron availability, inflammation and aluminium. Nephrol Dial Transplant 1998; 13: 82-88
4. Fishbane S. Safety in iron management. Am J Kidney Dis 2003; 41 [Suppl 5]: 18-26
5. McCarthy JT, Regnier CE, Loebertmann CL, Bergstralh EJ. Adverse events in chronic hemodialysis patients receiving intravenous iron dextran - a comparison of two products. Am J Nephrol 2000; 20: 455-462
6. Fletes R, Lazarus JM, Gage J, Chertow GM. Suspected iron dextran-related adverse drug events in hemodialysis patients. Am J Kidney Dis 2001; 37: 743-749
7. Faich G, Strobos J. Sodium ferric gluconate complex in sucrose: Safer intravenous iron therapy than iron dextrans. Am J Kidney Dis 1999; 33: 464-470
8. Fishbane S, Kowalski EA. The comparative safety of intravenous iron dextran, iron saccharate, and sodium ferric gluconate. Semin Dial 2000; 13: 381-384
9. Michael B, Coyne DW, Fishbane S et al. Sodium ferric gluconate complex in hemodialysis patients: Adverse reactions compared to placebo and iron dextran. Kidney Int 2002; 61: 1830-1839
10. Chertow GM, Mason PD, Vaage-Nilsen O, Ahlmen J. On the relative safety of parenteral iron formulations. Nephrol Dial Transplant 2004; 19: 1571-1575
11. Fleiss JL. Confidence intervals for the odds ratio in case-control studies: The state of the art. J Chronic Dis 1979; 32: 69-77
12. Bailie GR, Clark JA, Lane CE, Lane PL. Hypersensitivity reactions and deaths associated with intravenous iron preparations. Nephrol Dial Transplant 2005; 20: 1443-1449
13. Zager RA, Johnson AC, Hanson SY. Parenteral iron nephrotoxicity: potential mechanisms and consequences. Kidney Int 2004; 66: 144-156
14. Agarwal R, Vasavada N, Sachs NG, Chase S. Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease. Kidney Int 2004; 65: 2279-2289
15. Kalantar-Zadeh K, Don BR, Rodriguez RA, Humphreys MH. Serum ferritin is a marker of morbidity and mortality in hemodialysis patients. Am J Kidney Dis 2001; 37: 564-572
16. Pillon L, Piccoli A, Lowrie EG, Lazarus JM, Chertow GM. Vector length as a proxy for the adequacy of ultrafiltration in hemodialysis. Kidney Int 2004; 66: 1266-1271
17. U.S. Renal Data System. USRDS 2004 Annual Report. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2004
18. Ubel PA. Pricing Life: Why it's Time for Health Care Rationing. MIT Press, Cambridge, MA: 2000; 31-46